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INTRODUCTION: Hip and knee osteoarthritis (OA) are increasingly common with a significant impact on individuals and society. Non-pharmacological treatments are considered essential to reduce pain and improve function and quality of life. EULAR recommendations for the non-pharmacological core management of hip and knee OA were published in 2013. Given the large number of subsequent studies, an upda
The bonding of glass substrates is an important process in the fabrication of glass micro/nanofluidic devices. In this study, the influence of the surface roughness of glass substrates after low-temperature bonding is investigated. It is found that plasma etching can be used to control the surface roughness to the range 2-9 nm. Substrates with a roughness of 5 nm or less can be bonded. The pressur
Responsible internationalization is a term increasingly used to promote relationship building in a world shaped by the growing impact of global challenges and geopolitical competition. In these changing global conditions, researchers and universities have learned that they need to adhere to an expanded set of research norms. Today these norms include aspects well known to researchers, such as rese
A fundamental issue in the metabolic field is whether it is possible to understand underlying mechanisms that characterize individual variation. Whole-animal performance relies on mitochondrial function as it produces energy for cellular processes. However, our lack of longitudinal measures to evaluate how mitochondrial function can change within and among individuals and with environmental contex
Leveraging the potential of machine learning and recognizing the broad applications of binary classification, it becomes essential to develop platforms that are not only powerful but also transparent, interpretable, and user friendly. We introduce alphaML, a user-friendly platform that provides clear, legible, explainable, transparent, and elucidative (CLETE) binary classification models with comp
Asthma, which affects some 300 million people worldwide and caused 455,000 deaths in 2019, is a significant burden to suffers and to society. It is the most common chronic disease in children and represents one of the major causes for years lived with disability. Significant efforts are made by organizations such as WHO in improving the diagnosis, treatment and monitoring of asthma. However asthma
OBJECTIVE: The longitudinal variations in serum levels of the hormone osteocalcin is largely unknown during infancy and early childhood. Our aim was to establish reference limits for total serum osteocalcin during specific time points from birth until 5 years of age and present those in the context of sex, breastfeeding practices and gestational age (GA).DESIGN: Blood samples from 551 Swedish chil
Critical infrastructures (CIs) and the services they provide are imperative for the functioning of societies. CI safety and security have historically been addressed and regulated on a sectoral basis, despite their interdependent nature. These silo-structures potentially hinder achieving resilience from a system-of-systems governance perspective. Cross-sectoral initiatives addressing interdependen
We have built a new small furnace to perform high temperature studies up to 1200°C in vacuum or in oxygen atmosphere. This furnace was originally used as a catalytic reactor optimized for the in situ X-ray Absorption Spectroscopy experiments on beamline ID24. It has now been redesigned for use on the ESRF beamline ID01 for in situ Grazing Incidence Small Angle X-ray Scattering experiments. For the
Radiocarbon (14C), as a consequence of its production in the atmosphere and subsequent dispersal through the carbon cycle, is a key tracer for studying the Earth system. Knowledge of past 14C levels improves our understanding of climate processes, the Sun, the geodynamo, and the carbon cycle. Recently updated radiocarbon calibration curves (IntCal20, SHCal20, and Marine20) provide unprecedented ac
OBJECTIVE: To identify and characterize genetic loci associated with the risk of developing anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV).METHODS: Genetic association analyses were performed after Illumina sequencing of 1,853 genes and subsequent replication with genotyping of selected SNPs in a total cohort of 1110 Scandinavian cases with granulomatosis with polyangiit
A library of donor-acceptor system consisting of cyclopentadithiophene-based polymer photocatalysts have been designed and synthesized. Among all photocatalysts, the active PCPDTBSO achieved hydrogen evolution rates of 24.6 mmol h–1 g–1 with apparent quantum yields of 8.7 % at 500 nm. More importantly, combined the results of photocatalytic efficiency, apparent quantum yield, the time-resolved flu
As part of the IEA-SHC Task 41 'Solar Energy and Architecture' an international survey was carried out. This paper presents its results for Subtask B which especially focuses on methods and tools for solar design applied by architects. Building professionals, mainly architects, were contacted via email and asked to participate in a web-based questionnaire about their use of methods and tools for s
Caused by SARS-CoV-2, COVID-19 has become a severe threaten to society and human health, its epidemic control emerges as long-term issue. A sustainable epidemic and environmental transmission risk control (SEERC) in urban area is urgently needed. This work aims to conduct a new investigation on the transmission risk of SARS-COV-2 as virus/hazardous material through various environmental medias, ro
Retaining β-mannanases are glycoside hydrolases (GHs) that can potentially be applied for synthesis of glycosides by catalysis of transglycosylation reactions. A novel active-site double mutant (R171K/E205D) of the catalytic module (CM) of the family GH5 Trichoderma reesei β-mannanase (TrMan5A) was expressed in Pichia pastoris and purified. TrMan5A, CM and CM-variants R171K and R171K/E205D had pH
NTRU is a lattice-based public-key cryptosystem that has been selected as one of the Round III finalists at the NIST Post-Quantum Cryptography Standardization. Compressing the key sizes to increase efficiency has been a long-standing open question for lattice-based cryptosystems. In this paper we provide a solution to three seemingly opposite demands for NTRU cryptosystem: compress the key size, i
Mangroves, as unique coastal wetlands with numerous benefits, are endangered mainly due to the coupled effects of anthropogenic activities and climate change. Therefore, acquiring reliable and up-to-date information about these ecosystems is vital for their conservation and sustainable blue carbon development. In this regard, the joint use of remote sensing data and machine learning algorithms can
Metal halide perovskites have received great attention in recent years, predominantly due to the high performance of perovskite solar cells. The versatility of the material, which allows the tunability of the bandgap, has led to its use in light-emitting diodes, photo, and X-ray detectors, among other optoelectronic device applications. Specifically in photodetectors, the tunability of the bandgap
Metastatic castration-resistant prostate cancer is today incurable. Conventional imaging methods have limited detection, affecting their ability to give an accurate outcome prognosis, and current therapies for metastatic prostate cancer are insufficient. This inevitably leads to patients relapsing with castration-resistant prostate cancer. Targeting prostate-specific antigens whose expression is c
