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A highly functionalized six-membered cyclic carbonate, methacrylated trimethylolpropane (TMP) cyclic carbonate, which can be used as a potential monomer for bisphenol-free polycarbonates and isocyanate-free polyurethanes, was synthesized by two steps transesterifications catalyzed by immobilized Candida antarctica lipase B, Novozym®435 (N435) followed by thermal cyclization. TMP was functionalized
Infection with high-risk human papillomavirus (HPV) is causally related to cervical, vulvar and vaginal pre-invasive neoplasias and cancers. Highly effective vaccines against HPV types 16/18 have been available since 2006, and are currently used in many countries in combination with cervical cancer screening to control the burden of cervical cancer. We estimated the overall and age-specific incide
Diabetic patients suffer from macro- and microvascular complications causing increased morbidity and mortality. How hyperglycemia provokes vascular damage remains unclear, but glucose is believed to fuel a harmful low-grade chronic inflammation of the vessel wall. Previous work showed that glucose activates the transcription factor Nuclear Factor of Activated T cells (NFAT) in arteries ex vivo. NF
In January 2017, amidst the ongoing social strife in Venezuela, the Peruvian government enacted a working permit “Permiso Temporal de Permanencia” endowing Venezuelan migrants with the right to work and with access to health and education services. Given the spatial concentration of Venezuelan migrants in Peru and the clear temporal cut I unfold a difference-in-differences methodology to exploit t
Flow cytometry (FCM) is a powerful method for analysing cell characteristics, for cell quantification and for separation of different species. An automated FCM processing pipeline for lactic acid bacteria (LAB) was developed, and an analytical pipeline for co-cultures of LAB and Saccharomyces cerevisiae was designed. Data processing pipelines for Limosilactobacillus reuteri DSM 17938 sampled over
After the 2014 invasion of contested areas in Iraq by the so-called Islamic State (IS), the Yazidi community has suffered dire consequences. Genocide, sexual enslavement, forced religious conversion and forced displacement were some of these horrendous acts committed by IS against the Yazidi community and other minorities in Iraq and Syria. This thesis builds from the infusion of agonist theory in
In response to the environmental crisis and growing consumer awareness, increasing attention has been directed towards sustainable production models centred on circularity, resource efficiency, and reduced environmental impact. Against this background, practices such as upcycling, which aim to extend product lifespans and reduce waste, have gained increased attention. The European Union has artic
Den svenska rättsstaten står inför allvarliga prövningar. Det grova våldet till följd av skjutvapen har ökat markant i Sverige, och risken för tredje man att drabbad av skjutningar och detonationer på offentlig plats har ökat. Samtidigt som våldet även blivit mer hänsynslöst och likgiltigt. Antalet brott inom denna kategori ökar, men uppklaringsandelen är låg. En förklaring till den dystra statistThe Swedish rule of law is facing serious challenges. The use of firearms resulting in severe injury has increased significantly in Sweden, and the risk of third parties being affected by shootings and detonations in public places has increased. At the same time, the violence has become more ruthless and indifferent. While this type of violence is increasing, law enforcement agencies are at a loss
The drinking water and sanitation systems (WSS) in rural Kazakhstan have since its independence in 1991 been challenged with deteriorating implemented centralized systems where the population has been forced to explore individual, decentralized options to ensure a drinking water supply. With a limited documentation and classification of current WSS operating in rural settlements, the large-scale w
To support countries in reforming their research and innovation systems, the Directorate-General for Research & Innovation (DG RTD) of the European Commission set up a Policy Support Facility (PSF) under the European Framework Programme for Research & Innovation ‘Horizon 2020’. It aims to support Member States and associated countries in improving their national science, technology and inn
Aim: To evaluate aerobic exercise in migraine and co-existing tension-type headache and neck pain. Methods: Consecutively recruited persons with migraine and co-existing tension-type headache and neck pain were randomized into an exercise group or control group. Aerobic exercise consisted of bike/cross-trainer/brisk walking for 45 minutes, three times/week. Controls continued usual daily activitie
Background: Father's health is important for mothers and unborn/newborn children and knowledge about expectant fathers’ health in relation to lifestyle and psychosocial aspects is essential. Aims: To determine sociodemographic and lifestyle factors, self-reported health and sense of coherence among fathers and partners in relation to their risk for depression and anxiety in early pregnancy. Method
Fluorescence polarization is widely used to assess the orientation/rotation of molecules, and the excitation energy transfer between closely located chromophores. Emerging since the 1990s, single molecule fluorescence spectroscopy and imaging stimulate the application of light polarization for studying molecular organization and energy transfer beyond ensemble averaging. Here, traditional fluoresc
The optimal mode of delivery for a pregnant hemophilia carrier is still a matter of debate. The aim of the study was to determine the incidence of intracranial hemorrhage and other major bleeds in neonates with moderate and severe hemophilia in relationship to mode of delivery and known family history. A total of 926 neonates, 786 with severe and 140 with moderate hemophilia were included in this
The analysis of a road network could be carried out using different techniques, the most advanced of which for the identification of hazardous sites are based on a statistical tool known as a "Safety Performance Function" (SPF). SPFs are fundamental to procedures in the Highway Safety Manual (HSM) and Safety Analyst, both of which require calibration of the SPFs to local conditions. In the case of
Removing obstacles to e-commerce in the Single Market and ensuring effectivetaxation in the context of the digital economy has been high on the political agendaboth in the European Union and beyond. Recently the VAT rules on cross-border ecommerce have gone through a thorough modernisation with a package of newprovisions in the EU VAT legislation coming into effect as of 2019 and 2021. Furthermeas
To improve the management of the European eel (Anguilla anguilla) in freshwater, it is essential to define important lotic habitats. Electrofishing data from 289 wadeable, hard-bottom sites in 69 Swedish coastal rivers and streams, originally surveyed for salmonid monitoring, were used to evaluate the effects of sampling- and habitat-related factors on eel occurrence. Probability of eel occurrence
