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Low-grade superficial connective tumors are a heterogeneous group of benign/reactive, intermediate—locally aggressive and intermediate—rarely metastasizing lesions arising in skin and subcutaneous/superficial soft tissues. The most common targets for fine needle aspiration (FNA) in this group of lesions are schwannomas, desmoids, and “pseudosarcomatous lesions” such as nodular fasciitis. Experienc
This study explores the possibility that the delayed hypoperfusion observed after an ischemic insult might be due to vasoconstriction induced by the release of noradrenaline from nerves originating in the locus ceruleus. Bilateral 6-hydroxydopamine lesions of the ascending bundles from the locus ceruleus were carried out in the caudal mesencephalon of rats. Local CBF was measured with an autoradio
Normal sexual differentiation requires complex molecular events to take place in a precise order, and even though much knowledge has been gained in recent decades, further research is still needed to understand the pathogenesis of different disorders of sexual differentiation. For the clinician who is confronted with a child with sexual ambiguity, it is most important not to guess the sex but to i
The latest version of the Swiss standard for building acoustics (SIA181) introduced a new measurement method, based on a balanced- Arm hammer, for evaluating the decoupling performance of service equipment. This method was developed for reproducing in a standard manner the manipulation of service equipment in bathrooms and kitchens. In this study, we are investigating the relevance of such method
When acquiring simple three-dimensional (3d) trajectory data it is common to accumulate large coordinate data sets. In order to examine integrity and consistency of object tracking, it is often necessary to rapidly visualise these data. Ordinarily, to achieve this the user must either execute 3d plotting functions in a numerical computing environment or manually inspect data in two dimensions, plo
The formation of biomolecular condensates inside cells often involve intrinsically disordered proteins (IDPs), and several of these IDPs are also capable of forming dropletlike dense assemblies on their own, through liquid-liquid phase separation. When modeling thermodynamic phase changes, it is well known that finite-size scaling analysis can be a valuable tool. However, to our knowledge, this ap
We present a microfluidic device that can sort nanosized extracellular vesicles (EVs) based on electrokinetics and Deterministic Lateral Displacement (DLD). The device is made from PDMS using standard soft-lithography, can separate particles down to 200 nm, and what is more, can achieve almost two orders of magnitude higher throughput than an otherwise single electrokinetic DLD device.
Ground source heat pump systems, operating in conjunction with vertical ground heat exchangers, will play a key role in decarbonising heating and cooling of buildings. Design of traditional borehole heat exchangers relies on tools which implement routine analytical relationships between heat transferred and the temperature change in the ground and circulating thermal fluid. However, for novel pile
Kármán vortex streets are repeating patterns of swirling vortices, appearing when a fluid passes an obstacle at Re>50. We present an array of interacting vortices, a Kármán vortex city, that arises when a DNA solution flows through an array of micro posts at Re <0.5. Above thresholds in concentration and flow rate, the vortices formed behind posts interact, leading to concentration fluctuation wav
The evolution of surfaces exposed to an aggressive environment and mechanical load is studied. The evolution is the initial part of a stress corrosion process that leads to pitting, crack initiation and growing cracks. In conventional fracture analyses the growth rate of the crack may be computed using a modified Paris' law. However, a known or a postulated crack is required. A serious drawback is
The forest industry is one of Sweden’s most important business areas. As the use of paper is declining the need for this sector to find other alternatives is increasing. An attractive option to meet this demand is the establishment of forest biorefineries. However, economically suitable pretreatment methods for woody biomass, which minimize degradation of the structural carbohydrates and allow the
Hydrogels are a hydrophilic network of polymers (usually cross-linked polysaccharides) that are natural or synthetic. Applications of hydrogels are many in the biomedical field. Because of the high water absorption (10 to 200 grams of water per gram of hydrogel), hydrogels have a high degree of flexibility similar to natural human tissue. Human cells can be incorporated into the hydrogel, which in
Galactoglucomannans (GGM) can be used as a precursor for the production of surfactants, plastics, hydrogels etc. However, separation of galactoglucomannan (GGM) from lignin and lignin-carbohydrate-complexes using membrane filtration is difficult. Precipitation of GGM with anti-solvents is an approach that has been previously studied. A membrane filtration step prior to precipitation is economicall
Morphology represents a hitherto unexploited source of specificity in microfluidic particle separation and may serve as the basis for label-free particle fractionation. There is a wealth of morphological changes in blood cells due to a wide range of clinical conditions, diseases, medication and other factors. Also, blood-borne parasites differ in morphology from blood cells. We present the use of
