Sökresultat

Delamination plays a pivotal role during normal development and cancer. Previous work has demonstrated that delamination and epithelial cell movement within the plane of an epithelium are associated with a change in cellular phenotype. However, how this positional change is linked to differentiation remains unknown. Using the developing mouse pancreas as a model system, we show that β cell delamin

Sammanfattning Det naturvetenskapliga kunskapsläget om klimatförändringarna förbättrats ständigt genom forskningen om klimatsystemet, klimatpåverkan, klimatets variationer och förändringar samt klimateffekter. Kunskapsläget är väletablerat när det gäller den grundläggande fysiken bakom växthuseffekten, liksom att genomsnittstemperaturen vid jordytan stigit de senaste femtio åren. Det är också my

Wilms' tumor gene 1 (WT1) is a transcription factor involved in developmental processes. In adult hematopoiesis, only a small portion of early progenitor cells express WT1, whereas most leukemias show persistently high levels, suggesting an oncogenic role. We have previously characterized oncogenic BCR/ABL1 tyrosine kinase signaling pathways for increased WT1 expression. In this study, we show tha

This article gives an overview of some ethical problems raised in connection to nutritional genomics, especially the use of knowledge from nutrigenomics as a basis for personalised nutrition after a genetic test.

Introduction: Equity in access to and utilization of health services is a common goal of policy-makers in most countries. The current study aimed to evaluate the distribution of need and access to health care services among Iran's rural population between 2006 and 2009. Methods: Census data on population's characteristics in each province were obtained from the Statistical Centre of Iran and Natio

The aim of this study was to compare single-and twin-shaft oxy-fuel gas turbines in a semiclosed oxy-fuel combustion combined cycle (SCOC-CC). This paper discussed the turbomachinery preliminary mean-line design of oxy-fuel compressor and turbine. The conceptual turbine design was performed using the axial through-flow code LUAX-T, developed at Lund University. A tool for conceptual design of axia

Registry-based randomised controlled trials (R-RCTs) represent a paradigm shift in research, with the potential to accomplish pragmatic but large trials with high external validity. In this paper, we review our experiences from planning and performing the REgistry-based randomised controlled trial of treatment Duration and mortality in long-term OXygen therapy (REDOX) trial, the first R-RCT within

Utifrån tidigare forskning om och utvärderingar av musikämnets ställning i lärarutbildningen är syftet med förestående uppsats att ytterligare belysa musikämnets situation i den svenska lärarutbildningen såsom den manifesterar sig i kursplanerna på högskolor och universitet. Föremål för analys är samtliga lärarutbildningars kursplaner i det allmänna utbildningsområdet (AUO), som tillsammans med de

I ett samhälle med ökad globalisering blir regler angående den internationella privat- och processrätten allt viktigare. Denna uppsats behandlar lagvalsregler, vilka går att finna i Romkonventionen. Romkonventionens huvudregel är lagvalsfrihet. Det finns dock bestämmelser i konventionen som inskränker denna möjlighet. Artikel 7 rörande internationellt tvingande regler är ett exempel på detta och ä

Populärvetenskaplig sammanfattning: Jordens klimat står under ständiga variationer och förändringar, och det är inte alltid lätt att sära på orsak och verkan bland den mängd av faktorer som styr klimatet. För att kunna reda ut ursprunget till de förändringar som sker, måste de bakomliggande processerna vara väl kända. Sedan är det möjligt att genom matematiska modeller uppskatta de individuella prSeveral studies have analysed the relationship between Normalised Difference Vegetation Index (NDVI) and radiative surface temperature. A main goal for most studies have been to find the best method for carrying out land cover classifications and to study land cover changes, based on a combination between the two parameters. Since atmospheric components have a significant influence on both paramet

A group of chest physicians, general practitioners, clinical pharmacologist and pharmacists appointed by the Institute of Pharmacotherapy, University of Oslo has evaluated the present knowledge about treatment of chronic obstructive lung disease. The group discusses today's medical treatment of this rather numerous group of patients. It is stated that, to a high degree, the treatment of these pati

The Siemens gas turbine SGT-800 has an annular combustor and 30 dry low emission burners. In order to further reduce the emission levels and to obtain improved understanding of the flow and associated flame dynamics, single burner rig tests have been performed. The laboratory measurements are complemented by Large Eddy Simulation (LES) to analyze the effect on the flame dynamics due to the transie

This paper is part of an ongoing research on the trajectory of rhetoric of political reforms in Bahrain during the past 10-years of reign by king Hamad bin Isa. Within less than two years of his reign, the king abandoned his wide ranging blueprints for political and institutional reforms designed to end to a decade-long civil unrest. I argue that the king continues to use, albeit more creatively,

Purpose – This chapter presents a framework for an action research based intervention to develop and transform sustainable healthcare in a regional context. The framework is illustrated by the case of the Regional Cancer Centre (RCC) West in western Sweden. Design/methodology/approach – The framework draws upon and develops Pettigrew’s context-content-process model of strategic change and applies

Ever since Goldin-Meadow, S., C. Mylander, W. C. So, and A. Özyürek. 2008. The natural order of events: How speakers of different languages represent events nonverbally. PNAS 105: 9163–9168. proposed that there is a preferred order in sequential non-verbal event representations (Actor > Patient > Act), apparently independent of the default word order in one’s native language, the topic has been th