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Degree of certainty in scientific advice: implications for risk management and communication : Event report on a training workshop on uncertainty with risk managers

As part of its commitment to transparency, the European Food Safety Authority (EFSA) has been developing improved approaches to assessing uncertainty and expressing the degree of certainty in its scientific outputs. The objectives of this workshop were to review and improve the provision of this information by EFSA and its usefulness for risk managers, and to help risk managers to interpret and us

Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity

Stroke results in local neural disconnection and brain-wide neuronal network dysfunction leading to neurological deficits. Beyond the hyper-acute phase of ischemic stroke, there is no clinically-approved pharmacological treatment that alleviates sensorimotor impairments. Functional recovery after stroke involves the formation of new or alternative neuronal circuits including existing neural connec

Adverse Reactions after Vaccination and Allergen-Specific Immunotherapy: Contact Allergy to Aluminium and Itching Nodules

Popular Abstract in Swedish Oönskade reaktioner efter vaccination och allergenspecifik immunoterapi - Kontaktallergi för aluminium och kliande knutor För att ett vaccinationsprogram ska fungera krävs kontinuerlig uppföljning av vaccinernas säkerhet vad gäller eventuella oönskade reaktioner. Under de senaste 10 till 15 åren har en ökad oro noterats bland allmänhet och profession beträffande oönskadThe aim of the work presented in this thesis was to investigate two different types of adverse reactions, persistent itching nodules and contact allergy to aluminium, after immunization with aluminium-containing vaccines and aluminium-containing allergen extracts used for allergen-specific immunotherapy (ASIT). The first paper describes active parental reporting of adverse events (AEFIs) after a

Conditions for Reconciliation: Narratives of Survivors from the War in Bosnia and Herzegovina

Abstract in Uncoded languages Namen prispevka:Namen prispevka je analizirati ponovno podane izkušnje 27-ih preživelih vojne v Bosni in Hercegovini v 90-ih letih prejšnjega stoletja. V pripovedih smo pregledali verbalne znake sprave in pomiritve ter analizirali opisane izraze za spravo. Metode: Gradivo za raziskavo je bilo zbrano s kvalitativnimi intervjuji 27-ih posameznikov, ki so preživeli vojnoPurpose: The aim of this article was to analyze the retold experiences of 27 survivors from the 1990s war in Bosnia and Herzegovina. I have examined verbal markers of reconciliation and implacability and analyzed the described terms for reconciliation that are being actualized in the narratives. Design: The material for the study was gathered through qualitative interviews with 27 individuals who

The Use of Quotations in Discourse about Ethnicities

Examples from Czech and Swedish conversations illustrate how conversationalists use quotations when they define their own identity and when they speak about the identity of the others. The analysis is based on Tannens concept of constructed dialogue where direct quotation is seen as the creation of the speaker rather than the party quoted. The results indicate that quotations can be used strategic

Den historiska utvecklingen av internationell adoption på Sri Lanka - I linje med barnets bästa?

Under 1980-talet var Sri Lanka ett av de länder som flest barn adopterades internationellt ifrån, med 6815 registrerade adoptioner. Antalet adoptioner har sen dess fallit kraftigt. Under 2010-talet registrerades bara 259 stycken – detta trots den stora mängd barn som fortsatt växer upp på institutioner i landet. Hur kommer detta skifte sig och vad har det inneburit för barns rättigheter och tolkni

Att bli trampad på i mötet med psykiatrin: Förekomst och uttryck av kränkningar inom den vuxenpsykiatriska vården

Tidigare forskning har visat att patienter inom vuxenpsykiatrisk vård utsätts för kränkningar av vårdpersonal, där dehumanisering och stigmatisering av psykisk sjukdom ses som bidragande faktorer. Denna studie ämnade undersöka om det fanns skillnader mellan anmälningar till Inspektionen för vård och omsorg (IVO) rörande kränkande bemötande jämfört med anmälningar rörande andra bemötandebrister, utPrevious research has shown that patients in adult psychiatric care are subject to abuse by healthcare staff, where dehumanization and stigmatization of mental illness are seen as contributing factors. This study aimed to investigate whether there were differences between reports to the Health and Social Care Inspectorate (IVO) concerning abusive treatment compared to reports concerning other trea

Institutional Investors and Sustainability - An Analysis of Institutional Investors’ Legal Due Diligence Obligations

The European Union’s Sustainable Finance Agenda has launched several new actions in order to reorient capital flow of the financial market to sustainability objectives. One of these initiatives was to unify and harmonize the rules on marketing of sustainable aims of financial products. Financial Market Participant, including institutional investors, are obligated to disclose their due diligence po

Long-Term Outcome of Percutaneous Coronary Intervention Using Absorb Bioresorbable Scaffold : A SCAAR Study

Background: Bioresorbable scaffolds have been associated with inferior outcomes compared to contemporary permanent metallic drug-eluting stents (DES) for percutaneous coronary intervention, particularly within the initial years after implantation; however, their long-term performance remains uncertain. This study aimed to evaluate the long-term outcomes of Swedish patients treated with Absorb bior

Refugee livelihoods in Egypt and Lebanon

Beyond conventional relief efforts, gaining a more detailed picture of constraints, resources and risks encountered by refugees as well as of the meaning differing circumstances have for the concerned individuals may serve as a basis for developing more organised and collective responses to ensure social security in conditions of forced displacement and migration.Syrian refugees live very diverse

Adverse Lipid and Inflammatory Changes in Young Nondiabetic First-Degree Relatives of Type 1-Diabetic Patients

Background: Previous studies from our and other centers on young patients with type 1 diabetes (T1D) have indicated pro-atherosclerotic changes in the carotid arteries and in the lipid and systemic inflammatory profiles without a clear relationship between these changes and the hyperglycemic control. We have also earlier found in these patients a certain HLA-related genetic susceptibility to adver

Homelessness and risk of end-stage renal disease

To identify homeless people with chronic kidney disease (CKD) who were at highest risk for end-stage renal disease (ESRD), we studied 982 homeless and 15,674 domiciled people with CKD receiving public health care. We developed four risk prediction models for the primary outcome of ESRD. Overall, 71 homeless and 888 domiciled people progressed to ESRD during follow-up (median: 6.6 years). Homeless

Derivation and validation of the CREST model for very early prediction of circulatory etiology death in patients without ST-segment-elevation myocardial infarction after cardiac arrest

BACKGROUND: No practical tool quantitates the risk of circulatory-etiology death (CED) immediately after successful cardiopulmonary resuscitation in patients without ST-segment-elevation myocardial infarction. We developed and validated a prediction model to rapidly determine that risk and facilitate triage to individualized treatment pathways. METHODS: With the use of INTCAR (International Cardia

Changes in Practice of Controlled Hypothermia after Cardiac Arrest in the Past 20 Years : A Critical Care Perspective

For 20 years, induced hypothermia and targeted temperature management have been recommended to mitigate brain injury and increase survival after cardiac arrest. On the basis of animal research and small clinical trials, the International Liaison Committee on Resuscitation strongly advocated hypothermia at 32-34 °C for 12-24 hours for comatose patients with out-of-hospital cardiac arrest with initi