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Who should obey Asimov's Laws of Robotics? A question of responsibility

The aim of this chapter is to explore the safety value of implementing Asimov's Laws of Robotics as a future general framework that humans should obey. Asimov formulated laws to make explicit the safeguards of the robots in his stories: (1) A robot may not injure or harm a human being or, through inaction, allow a human being to come to harm; (2) A robot must obey the orders given to it by human b

The unintended consequences of modernity : Pollution and its effect on reproductive, maternal and fetal health

Over the past 50 years there has been an unprecedented increase in pollution globally. Population growth and higher standards of living have resulted in increases in global consumption facilitated by industrialisation and globalisation of goods and services thus resulting in the release of environmental pollutants on a mass scale. This article analyses the effects and consequences of pollution on

Accelerating the implementation of the Sustainable Development Goals at the local level. : Unpacking governance processes and tensions

Despite a growing body of research on the role of the Sustainable Development Goals (SDGs) at the local level, knowledge on how they are taken up in local governance processes remains limited. This article contributes to knowledge on SDG implementation by examining how the SDGs can contribute to governance change at the local level. We develop a process-oriented analytical framework that examines

Men’s Experience of Abuse During Child- and Adulthood and Identification of Self as Perpetrator : A Cross-Sectional Study in Psychiatric Care

The aim of this study was to describe the extent to which men in psychiatric care have experienced emotional, physical, and sexual abuse during the life course and the association between this experience and being a perpetrator oneself. The aim was also to identify who exposed them to abuse and whether there was an association between the category of abuser and being a perpetrator oneself. A cross

Protein identification by in-gel digestion, high-performance liquid chromatography, and mass spectrometry: peptide analysis by complementary ionization techniques

A biologically active protein fraction was isolated from rabbit intestine, purified by one-dimensional SDS-PAGE and stained with Coomassie Brilliant Blue. A predominant band of approximately 110-130 kDa was excised and digested in-gel with trypsin. The resulting peptides were extracted then separated by microbore reversed-phase high-performance liquid chromatography (HPLC). Mass spectrometric data

Annualreport-2022

Centre for Retail Research at Lund University ANNUAL REPORT | 2022 2 ANNUAL REPORT CENTRE FOR RETAIL RESEARCH AT LUND UNIVERSITY 2022 3 ANNUAL REPORT CENTRE FOR RETAIL RESEARCH AT LUND UNIVERSITY 2022 Introduction Centre for Retail Research – the ninth year: 2022 You have in your hand the ninth annual report from the Centre for Retail Research at Lund University. We will have our tenth anniversary

https://www.lusem.lu.se/sites/lusem.lu.se/files/2024-01/annualreport-2022.pdf - 2026-05-28

Using quantum annealing to design lattice proteins

Quantum annealing has shown promise for finding solutions to difficult optimization problems, including protein folding. Recently, we used the D-Wave Advantage quantum annealer to explore the folding problem in a coarse-grained lattice model, the HP model, in which amino acids are classified into two broad groups: hydrophobic (H) and polar (P). Using a set of 22 HP sequences with up to 64 amino ac

Abnormally high exertional breathlessness predicts mortality in people referred for incremental cycle exercise testing

Background Exertional breathlessness is a key symptom in cardiorespiratory disease and can be quantified using incremental exercise testing, but its prognostic significance is unknown. We evaluated the ability of abnormally high breathlessness intensity during incremental cycle exercise testing to predict all-cause, respiratory, and cardiac mortality. Study design and methods Longitudinal cohort s

Exploring the impact of age on the predictive power of the National Early Warning score (NEWS) 2, and long-term prognosis among patients reviewed by a Rapid Response Team : A prospective, multi-centre study

Aim: To explore the impact of age on the discriminative ability of the National Early Warning Score (NEWS) 2 in prediction of unanticipated Intensive Care Unit (ICU) admission, in-hospital cardiac arrest (IHCA) and mortality within 24 hours of Rapid Response Team (RRT) review. Furthermore, to investigate 30- and 90-day mortality, and the discriminative ability of NEWS 2 in prediction of long-term

From the captains of industry to the trustees of sustainability : the positioning of the large family-owned companies' core values regarding the Green Deal for Europe's decarbonization goals

Significant behavioral changes will need to be implemented to prevent the energy supply sector from tripling CO2 emissions by the midcentury. However, within the academic research, behavior changes remain primarily focused on the individual level, while the behavior of companies that are responsible for elevated greenhouse gas emissions falls behind. This master’s thesis analyses the core values

Inequity in access to digital public primary healthcare in Sweden: a cross-sectional study of the effects of urbanicity and socioeconomic status on utilization

BackgroundSocial and geographical inequity in access to primary healthcare is an ongoing concern in Sweden. Digital care can potentially decrease geographical inequity. This study aimed to evaluate how urbanicity affects the utilization of a public digital primary healthcare service - PHC Online.MethodsWe performed an ecological cross-sectional study of 4,482 PHC Online visits grouped by 83 public

One week sweating simulation test with a thermal foot model

This study aimed to find out how the insulation of the footwear changes over one week of use. A thermal foot model with 8 measuring zones and 5 “sweat glands” was used for tests. A thin sock was donned on the model to allow better water distribution all over the foot surface. Four boots were tested over a period of 5 days. Each day was divided into 9 hour measurement period and 15 hour conditionin

Strain fields and mechanical response of a high to medium fissured bentonite clay

This article presents the developments of an ongoing research aimed at modelling the influence of fissuring on the behaviour of clays. In particular, it recalls the main results of an extensive laboratory investigation on a fissured bentonite clay from the south of Italy and presents the data of a new investigation on the evolution with shearing of the strain fields developing within the clay, res

Leukemia Initiation in MLL-ENL Mediated Leukemogenesis

Popular Abstract in Swedish Varje dag producerar vår kropp många miljarder nya blodceller. Dessa celler är livsnödvändiga för att många funktioner i kropp ska fungera. Exempelvis hjälper de till med att skydda oss från sjukdomar, läka skador, och med att transportera syre och avfallsämnen. Blodsystemet (det hematopoetiska systemet) är uppbyggt som en hierarki där hematopoetiska stamceller finns påIn the blood system, knowledge on the regulation of hematopoietic stem cells (HSCs) and their immature progeny has provided roadmaps of differentiation. Such information can also have a value to understand the etiology of hematological cancers, since clinical heterogeneity and prognostic therapeutic outcomes have been proposed to associate with the specific developmental stage from which the trans

Acidosis enhances translocation of protein kinase C but not Ca2+/calmodulin-dependent protein kinase II to cell membranes during complete cerebral ischemia

Systemic hyperglycemia and hypercapnia severely aggravate ischemic brain damage when instituted prior to cerebral ischemia. An aberrant cell signaling following ischemia has been proposed to be involved in ischemic cell death, affecting protein kinase C (PKC) and the calcium calmodulin kinase II (CaMKII). Using a cardiac arrest model of global brain ischemia of 10 min duration, we investigated the

Models for studying long‐term recovery following forebrain ischemia in the rat. 2. A 2‐vessel occlusion model

ABSTRACT— A model is described in which transient ischemia is induced in rats anaesthetized with N2O:O2 (70:30) by bilateral carotid artery clamping combined with a lowering of mean arterial blood pressure to 50 mm Hg, the latter being achieved by bleeding, or by bleeding supplemented with administration of trimetaphan or phentolamine. By the use of intubation, muscle paralysis with suxamethonium

Cortical spreading depression is associated with arachidonic acid accumulation and preservation of energy charge

The present study aimed to study the relation between the release of arachidonic acid (AA) and the energy state in cerebral cortices of rats during single episodes of cortical spreading depression (CSD). The changes in concentrations of AA, labile phosphate compounds [ATP, ADP, AMP, and phosphocreatine (PCr)], and glycolytic metabolites (lactate, pyruvate, glucose, and glycogen) were studied durin