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Urban air pollution disrupts placental microarchitecture and shifts hofbauer cells towards a pro-inflammatory state

Exposure to urban air pollution during early pregnancy is associated with increased risk for adverse pregnancy outcomes, such as preeclampsia (PE), and there is an urgent need to understand how air pollution affects biological mechanisms in the placenta. Hofbauer cells (HBCs) are fetal placental macrophages that regulate immune tolerance in the placenta. They are normally polarized towards an anti

AI-verktyg för journalföring - Klassificering och rättsliga konsekvenser enligt AI-förordningen

Artificiell intelligens har under de senaste åren fått en allt större betydelse inom hälso- och sjukvården. En framväxande tillämpning är AI-verktyg för journalföring, som automatiserar delar av det administrativa arbetet genom att omvandla tal till text, strukturera anteckningar och i vissa fall föreslå diagnoser eller remisser. Verktygen kan effektivisera vårdpersonalens arbete, men väcker samtiIn recent years, artificial intelligence has gained increasing importance within the healthcare sector. One emerging application is AI medical scribes, which automate parts of administrative work by converting speech to text, structuring clinical notes, and in some cases suggesting diagnoses or referrals. These tools have the potential to improve the efficiency of healthcare professionals, but at

Economic Evaluation of Long-term Oxygen Therapy: 24 hours versus 15 hours per Day in Severe Hypoxemia: the REDOX Trial

BackgroundLong-term oxygen therapy (LTOT) given for at least 15 hours/day improves survival in patients with severe chronic hypoxemia. However, the recent REDOX trial showed that LTOT prescribed for 24 hours/day was not superior to 15 hours/day in terms of death, hospitalizations, or self-reported outcomes. We aimed to examine the cost effectiveness of prescribing LTOT for 24 versus 15 hours/day.M

Moving beyond Mediatized Activism for Social Justice: Creating Visual Safe/Brave Spaces for Activists

The large-scale mass mobilizations and colossal demonstrations of the last decade have shown that digital and social media platforms, globally, now play significant roles in early formation and further facilitation of activist movements, interested in progressive causes and societal changes. However, the repercussions of the very same events have also clearly shown the shortcomings of mediatized a

Dying With Unrelieved Pain-Prescription of Opioids Is Not Enough

CONTEXT: Fear of pain resonates with most people, in particular, in relation to dying. Despite this, there are still people dying with unrelieved pain.OBJECTIVES: We quantified the risk, and investigated risk factors, for dying with unrelieved pain in a nationwide observational cohort study.METHODS: Using data from Swedish Register of Palliative Care, we analyzed 161,762 expected deaths during 201

Sports-Related Traumatic Brain Injury

The speed and intensity of modern sports puts the athlete at risk for impacts to the head, or to the body when the impact force is transmitted to the head. Rapid head rotation caused by these impact forces may lead to a sports-related concussion (SRC), defined as a mild traumatic brain injury, typically resulting in short-lived disturbance of the central nervous system function. The diagnosis of S

The Home as a Place for Rehabilitation After Stroke : Emerging Empirical Findings

Health care is moving toward integrated services where care and rehabilitation are provided at home rather than in institutions. This, together with the requirement that care must be person-centered, has proven to be a considerable challenge. Older adults living with complex health conditions such as stroke are vulnerable to change when their responsibility for care and rehabilitation becomes exte

Information Management as a Tool for Organizational Learning in Academic Libraries

In this paper, I briefly present my doctoral thesis research proposal. Recognizing that information has long been an important asset for any organization, I wish to explore in depth the management and use of information in contemporary information-intensive organizations such as academic libraries. Additionally, this research proposal emerges out of recognition that the academic library is a dynam

The first comprehensive population size estimations for the highly endangered largest diving beetle Dytiscus latissimus in Europe

Dytiscus latissimus (Coleoptera Dytiscidae) is an endangered diving beetle throughout its range. It is one of the two species of Dytiscidae listed in Annex II of the Habitats Directive, IUCN red list and in many national level legislations and therefore strictly protected. The conservation of endangered species first of all requires an assessment of their population size. Until now, a method has n

Host shift and natural long-distance dispersal to an oceanic island of a host-specific parasite

Parasite dispersal and host-switching may be better understood by knowing when they occurred. We estimated when the ancestor of a parasite of great reed warblers (Acrocephalus arundinaceus) dispersed to the Seychelles and began infecting the endemic Seychelles warbler (A. sechellensis). We used mitochondrial genomes and published molecular divergence rates to estimate the date of divergence betwee

A critical typology of "good place branding" : Lessons from place-branding expertise

Place branding is defined as “the development of brands for geographic locationswith the aim of triggering positive associations about the area and distinguishinga place from other places” (Stevens et al., 2020, p. 752). Like all occupations,place branding is organised by discourses, or talk, that determine best practices andnorms about what constitutes expertise (Loacker and Sullivan, 2016). Expl

Exceptions and limitations (27 UPCA)

The UPCA for the first time establishes harmonized exceptions and limitations to the effects of granted patent rights. Previously these were the sole province of national law but a with a degree of similarity.This chapter briefly analyses the historical origin, legal nature and scope of Article 27 UPCA, the future harmonizing effect of UPCA patent limitations, followed by a discussion on each limi

Formation and photoluminescence of Ge and Si nanoparticles encapsulated in oxide layers

Ge and Si semiconductor nanoparticles encapsulated in oxide layers were prepared by the inert gas condensation method. High-resolution electron microscopy and energy dispersive X-ray spectrometry showed the formation of the core-shell structures with a size below 10 nm. The optical absorption spectra of Ge showed the band edges at higher energy compared to the ordinary Ge element. Photoluminescenc

English Medium Instruction in Multilingual and Multicultural Universities : Academics’ Voices from the Northern European Context

English Medium Instruction in Multilingual and Multicultural Universities analyses the issues related to EMI at both a local and international level and provides a broad perspective on this topic. Drawing on field studies from a Northern European context and based primarily on research carried out at the University of Copenhagen, this book:• introduces a topical global issue that is central to the

Sphingosine-1-Phosphate, a Marker of Endothelial Injury and Disease Severity in Preeclampsia

BACKGROUND: Preeclampsia is a hypertensive pregnancy disorder marked by endothelial damage. Healthy endothelium is covered by a protective glycocalyx layer, which, when degraded, releases detectable products into the blood. Sphingosine-1phosphate (S1P) is a cardiovascular biomarker involved in glycocalyx preservation, linked to placentation and preeclampsia development. The study aimed to test the

Plasma endostatin at intensive care admission is independently associated with acute kidney injury, dialysis, and mortality in COVID-19

BackgroundCritical COVID-19 is associated with high mortality, and acute kidney injury (AKI) is common. Endostatin has emerged as a promising prognostic biomarker for predicting AKI and mortality in intensive care. This study aimed to investigate plasma endostatin at intensive care unit (ICU) admission as a biomarker for AKI, renal replacement therapy (RRT), and 90-day mortality in COVID-19.Method

Effects of pre-treatment on characterization of microplastics in biosolids via optical photothermal infrared spectroscopy

Microplastics (MPs) in biosolids used as soil amendments are of growing concern. The purpose of this study was to improve the characterization of MPs in complex biosolid matrices by optimizing sample preparation for morphological and chemical analyses with different spectroscopic techniques. We compared extraction procedures involving Fenton oxidation (F), Fenton plus sodium dodecyl sulfate (SDS),