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Cardiac output during targeted temperature management and renal function after out-of-hospital cardiac arrest

Purpose: After resuscitation from out-of-hospital cardiac arrest (OHCA), renal injury and hemodynamic instability are common. We aimed to assess the association between low cardiac output during targeted temperature management (TTM) and acute kidney injury (AKI) after OHCA. Materials and methods: Single-center substudy of 171 patients included in the prospective, randomized TTM-trial. Hemodynamic

Coronary Angiography and Intervention in Women Resuscitated From Sudden Cardiac Death

Background Coronary artery disease is the primary etiology for sudden cardiac arrest in adults, but potential differences in the incidence and utility of invasive coronary testing between resuscitated men and women have not been extensively evaluated. Our aim was to characterize angiographic similarities and differences between men and women after cardiac arrest. Methods and Results Data from the

A shift from technical properties towards sensorial characteristics in product design education

The aim of this study is to evaluate a new pedagogic approach implemented in a compulsory materials course for product design students at bachelors level at ABC University. When developing a new curriculum for the material course, a decision was made to teach materials and production methods in a contextualized setting with emphasis on how students can deal with materials in a design process. Meth

Quantitative in-cylinder fuel measurements in a heavy duty diesel engine using structured laser illumination planar imaging (SLIPI)

Laser-induced fluorescence (LIF) for quantitative fuel concentration measurements in a combustion engine is a challenging task. Measuring close to the walls of the combustion chamber is even more challenging as both the incident laser light and the signal are strongly reflected on the walls of the combustion chamber. By using a new technique called Structured Laser Illumination Planar Imaging (SLI

High resolution modelling of elemental carbon for Denmark

Elemental Carbon (EC) has been in focus for a long time due to its importance for climate effects and human health (WHO / IPCC). The pollutant is released by incomplete combustion of carbon fuels, making road traffic, off-road machinery, and wood stove burning the largest sources of EC emissions. In this work, we investigate the distribution of EC over Denmark using a combination of three models w

Unraveling the World’s Longest Non-stop Migration : The Indian Ocean Crossing of the Globe Skimmer Dragonfly

Insect migration redistributes enormous quantities of biomass, nutrients and species globally. A subset of insect migrants perform extreme long-distance journeys, requiring specialized morphological, physiological and behavioral adaptations. The migratory globe skimmer dragonfly (Pantala flavescens) is hypothesized to migrate from India across the Indian Ocean to East Africa in the autumn, with a

Cell differentiation in acute myeloid leukemia

Acute myeloid leukemia (AML) is characterized by a differentiation block leading to accumulation of immature cells. Chromosomal translocations in AML affect transcription factors that are involved in regulation of myeloid differentiation. Aberrant expression of these factors interferes with differentiation events and has a role in the pathogenesis of AML through superactivation or (dominant negati

Preferences for Gender Affirming Treatment and Associated Factors Among Transgender People in Sweden

Introduction: Gender affirming surgery of primary and/or secondary sex characteristics has been shown to alleviate gender dysphoria. A descriptive snapshot of current treatment preferences is useful to understand the needs of the transgender population seeking health care. This study aimed to describe preferences for gender affirming treatment, and their correlates, among individuals seeking healt

Specialized palliative care and the quality of life for hospitalized cancer patients at a low-resource hospital in India

Aim: This study aimed to compare the quality of life (QoL) of cancer patients, with an Eastern Cooperative Oncology Group (ECOG) performance of 3-4, in contact with or without contact, with a specialized palliative care unit (PCU) at a low-resource governmental cancer hospital, as well as studying the impact of this contact on the QoL in their caregivers. Materials and Methods: Hospitalized patien

Interventions for treatment of COVID-19 : A protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project)

Background: COVID-19 is a rapidly spreading virus infection that has quickly caused extensive burden to individual, families, countries, and the globe. No intervention has yet been proven effective for the treatment of COVID-19. Some randomized clinical trials assessing the effects of different drugs have been published, and more are currently underway. There is an urgent need for a living, dynami

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Malignant melanoma (MM) is a frequent form of cancer with increasing incidence. 6-10% of patients with MM report a family history of MM, and in most populations 2% of unselected cases of MM carry a CDKN2A mutation. tvWe present a family with 24 cases of MM in nine persons from several generations, caused by a previously undescribed germ-line intronic mutation in CDKN2A. Through genetic counselling

Gene expression profiling of first trimester placentas from pregnancies at high risk of developing preeclampsia

INTRODUCTION: Preeclampsia (PE) is an important cause of fetal and maternal morbidity and mortality. It is considered a two-stage disease, the first stage characterized by a defect placentation and the second stage by maternal manifestations. Details of the patho-physiology behind the transition from stage one to stage two remain unclear.OBJECTIVE: Was to study first trimester placental gene expre