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AIMS: This study assessed radiotherapy combined with capecitabine and oxaliplatin in patients with primary, inextirpable colorectal adenocarcinoma. PATIENTS AND METHODS: Forty-nine patients entered the trial. Two cycles of XELOX (capecitabine 1000mg/m(2) bid d1-14+oxaliplatin 130mg/m(2) d1, q3w) were followed by radiotherapy (50.4Gy), combined with capecitabine 825mg/m(2) bid every radiotherapy da
The purpose of this study was to evaluate an abdominal CT protocol in which radiation dose was reduced and IV contrast dose increased for young patients and radiation dose was increased and IV medium dose decreased for elderly patients. The hypothesis was that these adjustments would result in constant image quality and a reduction in age-specific risk.
OBJECTIVES: To evaluate the prophylactic efficacy of the human papillomavirus (HPV) quadrivalent vaccine in preventing low grade cervical, vulvar, and vaginal intraepithelial neoplasias and anogenital warts (condyloma acuminata). DESIGN: Data from two international, double blind, placebo controlled, randomised efficacy trials of quadrivalent HPV vaccine (protocol 013 (FUTURE I) and protocol 015 (F
Susceptibility to osteoporotic fracture is influenced by genetic factors that can be dissected by whole-genome linkage analysis in experimental animal crosses. The aim of this study was to characterize quantitative trait loci (QTLs) for biomechanical and two-dimensional dual-energy X-ray absorptiometry (DXA) phenotypes in reciprocal F2 crosses between diabetic GK and normo-glycemic F344 rat strain
Abstract Background and aims. The incidence of celiac disease (CD) shows large, worldwide variation. However, whether its causes are environmental (gluten-containing diet) or genetic (specific haplotype) have not been established. The aim of the present study is to examine the incidence of CD among second-generation immigrants and adoptees from abroad to disentangle genetic/ethnic versus environme
Aim. The aim of this study is to examine associations between caregiver burden, perceived health and sense of coherence in family caregivers to persons with dementia living at home. Background. Most of the studies on family caregivers have focused on burden and morbidity. However, the caregiver's sense of coherence and perceived health have not been studied earlier in relation to caregiver burden.
Popular Abstract in Swedish Esofagektomi (kirurgiskt avlägsnande av matstrupen) är ett omfattande ingrepp som främst utförs pga cancer, men som även utförs vid vissa godartade sjukdomar. Matstrupen sträcker sig från svalget, via bakre delen av bröstkorgen ned till övre delen av buken. Det anatomiska läget gör att man ur kirurgisk synpunkt oftast måste avlägsna matstrupen via en kombination av inciIn a prospective randomised study following oesophagectomy and gastric tube reconstruction patients with hand-sutured neck anastomoses were compared with patients with circular stapled chest anastomoses. The two groups had equal rates of anastomotic or conduit leaks of 7.3 % (3/41) and 7.1 % (3/42) and of benign anastomotic strictures of 19.5 % (8/41) and 28.6 % (12/42). Another prospective random
This chapter presents key energy use figures and explores the energy saving potential for electric lighting in office buildings based on a review of relevant literature, with special emphasis on a North European context. The review outlines that an energy intensity of around 10 kWh/m2yr is a realistic target for electric lighting in future low energy office buildings, based on theoretical calculat
This paper offers an analysis of a case of cooperation, and in particular cooperation problems, between independent performing arts organisations in the region of Skåne, Sweden. The cooperation in question flows from visions of the organisations, and linked regional commission to develop the infrastructure and networks of the independent performing arts in Skåne. The case gives evidence of the cha
Popular Abstract in Swedish Under det senaste decenniet har risker med och alternativ till allogent blod (blod från främmande givare) debatterats mycket pga. risken för smitta, allergiska reaktioner, samt starka indicier som talar för att blod från främmande givare kan påverka immunförsvaret hos mottagaren. Därför vill man gärna begränsa mängden tillfört givarblod under kirurgiska ingrepp på barn,In children, it is often desirable to minimize allogenic blood transfusion, and this thesis explores the physiology of an alternative method of managing perioperative blood loss: hemodilution with Ringer´s dextran. Methods Clinical studies: Arterial pressure, superior caval venous oxygen saturation (ScvO2) and blood lactate concentration (L) were studied during bone marrow harvesting (BMH) on 23
Exoplanets have been observed at many stages of their host star's life, including the main-sequence (MS), subgiant and red giant branch stages. Also, polluted white dwarfs (WDs) likely represent dynamically active systems at late times. Here, we perform three-body simulations which include realistic post-MS stellar mass-loss and span the entire lifetime of exosystems with two massive planets, from
A literature review and a questionnaire study with 62 participants were carried out to provide recommendations on the design of a set of evacuation systems for road tunnels: 1) Traffic Information Sign (TIS) - message and size of the sign (large or small), colour scheme, and use of pictograms and/or flashing lights, 2) Emergency exit portal layout - colour scheme, 3) Acoustic systems - voice messa
Our aims were to characterize familial hypercholesterolemia (FH) in a Swedish FH population and to further elucidate the clinical expression and treatment response in relation to genotype. Secondly, we wanted to identify gene variants, which may have impact on cholesterol levels in apparently healthy subjects. In the search for sequence alterations in the large LDL receptor gene we introduced and
Historical demography, which is the study of human population dynamics in the past, is central for understanding human behaviours and traits, such as fertility, mortality and migration. An important factor in demographic research is the geographic context. Where people lived often determined their social ties, exposure to diseases and economic development. Such information is essential not only fo
