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Preclinical data indicate that oestrogen appears to play a beneficial role in the pathophysiology of and recovery from critical illness. In few previous epidemiologic studies, however, have researchers analysed premenopausal women as a separate group when addressing potential gender differences in critical care outcome. Our aim was to see if women of premenopausal age have a better outcome followi
A search for strongly produced supersymmetric particles is conducted using signatures involving multiple energetic jets and either two isolated leptons (e or mu) with the same electric charge, or at least three isolated leptons. The search also utilises jets originating from b-quarks, missing transverse momentum and other observables to extend its sensitivity. The analysis uses a data sample corre
Zircon Lu-Hf isotopic data from granites of southern and northwestern Ghana have been used to investigate the contribution of reworked Archaean bedrock to the Birimian crust of Ghana, West African Craton. Zircon from seven localities in southern Ghana and one locality in western Ghana were analysed. Combined U-Pb and Lu-Hf isotope data suggest juvenile crustal addition between 2.3–2.1 Ga, with a s
High prolactin levels have been associated with increased breast cancer risk. Prolactin is essential for breast-feeding. Prolactin is lowered primarily by the first full-term pregnancy and not by subsequent pregnancies. The protection from breast cancer conferred by a long breast-feeding duration (>1 year) seems to be much greater for women with BRCA1 mutations (45%) than for women in the general
Purpose: Knowledge of the blood pharmacokinetics of monoclonal antibodies is crucial in deciding the optimal time for starting the administration of a "clearing agent"or using a "clearing device." The primary purpose was to investigate whether the pharmacokinetics of various antibodies labeled with the same chelator and In-111 differed significantly after i.v. injection in immunocompetent rats. A
Defective assembly of alpha 3 alpha 4 alpha 5(IV) collagen in the glomerular basement membrane causes Alport syndrome, a hereditary glomerulonephritis progressing to end-stage kidney failure. Assembly of collagen IV chains into heterotrimeric molecules and networks is driven by their noncollagenous (NC1) domains, but the sites encoding the specificity of these interactions are not known. To identi
New laser stepwise heating Ar-40-Ar-39 dates (415 +/- 1.8 and 414 +/- 2 Ma) from the Etive Dyke Swarm in the SW Grampian Highlands of Scotland indicate that the dykes are 10-20 Ma older than previously assumed. The dykes constitute the final phase of the Late Caledonian Granites in the region, which themselves define the end of the Caledonian Orogeny, therefore these dates can be taken as the end
Treatment with alkali, particularly overliming, has been widely used as a method for the detoxification of lignocellulose hydrolysates prior to ethanolic fermentation. However, the mechanisms behind the detoxification effect and the influence of the choice of cation have not been well understood. In this study, a dilute acid hydrolysate of spruce and an inhibitor cocktail consisting of six known i
Background: The study was designed to determine whether a 1-year hospital-based secondary prevention programme would have any long-term effects on serum lipid levels and the use of lipid-lowering drugs in patients with coronary artery disease 4 years after referral to primary care facilities for follow-up. Design/methods: After acute myocardial infarction or coronary bypass surgery, 241 consecuti
The FRR (Friendly Rest Room) project creates and evaluates prototypes of a more user friendly intelligent toilet for old persons and for persons with disabilities. Additionally, applicable knowledge regarding needs and wishes of old and/or disabled persons and their care persons are documented. In this paper the user driven research approach, ethical aspects and the iterative user centred design p
TB PNA FISH is a new fluorescence in situ hybridization (FISH) method using peptide nucleic acid (PNA) probes for differentiation between species of the Mycobacterium tuberculosis complex (MTC) and nontuberculous mycobacteria (NTM) in acid-fast bacillus-positive (AFB+) cultures is described. The test is based on fluorescein-labelled PNA probes that target the rRNA of MTC or NTM species applied to
The nucleotide sequences of the variable region genes encoding five different human, high affinity antibodies, specific for the major neutralization determinant (AD-1) expressed by human cytomegalovirus glycoprotein B (gp58/116), have been determined. Three of the five heavy chain variable regions belonged to the small VHV-family, although they combined with a diverse set of light chains (V kappa
A dosing strategy for the transient control of an exhaust after-treatment system using the NOx storage and reduction approach was developed on a heavy-duty diesel engine rig equipped with an I I I diesel engine. The catalysts were oxidation catalysts of 8.41 and NOx storage and reduction catalysts of 16.8 1 total volume. The dosing strategy has been tested in a European Transient Cycle (ETC) resul
The literature identifies two forms of business organization, Neocorporatist and firm-level, and the strength of each respective type has changed over time; whereas Neocorporatism has remained steady or declined, firm-level organization has become stronger in all countries. The literature underscores the differential effects of these two forms of business organization on employer support for activ
Study Type - Diagnostic (exploratory cohort) Level of Evidence 2b OBJECTIVES: To assess variation of total prostate-specific antigen (tPSA), free PSA (fPSA), percent fPSA, human glandular kallikrein 2 (hK2) and intact PSA measured three times within 2 weeks. Knowledge of the variation in an individual's PSA level is important for clinical decision-making. PATIENTS AND METHODS: Study participants w
For pt.III see J. Math. Phys., vol.28, p.260 (1987). The one-dimensional inverse scattering problem is considered for lossy inhomogeneous media for the case in which the phase velocities at the two boundaries of the scatterer do not match that of the host medium. The model problem involves electromagnetic wave propagation in a medium of unknown thickness with spatially varying permittivity and con
The International Network for Pediatric Hemophilia (INPH) comprises a group of physicians committed to the unique care of and challenges facing pediatric hemophilia patients. By collaborating on an international level, extensive experience can be shared on current practice, new trends can be discussed and scientifically valid studies can be developed and performed. The three overall objectives of
The aim of the study was to explore nursing students' experiences of aspects important for their learning process and their ability to handle the complexity of the nursing degree program. The study was longitudinal and qualitative based on interviews with nursing students, six women and two men aged 20-36, during their three years of education. In all, seven patterns were found embracing aspects o
