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Background: About 20% of patients with colorectal cancer have liver metastases at the time of diagnosis, and surgical resection offers a chance for cure. The aim of the present study was to compare outcomes for patients that underwent simultaneous resection to those that underwent a staged procedure with the bowel-first (classical) strategy by using information from two national registries in Swed
The United Arab Emirates National Diabetes and Lifestyle Study (UAEDIAB) has identified obesity, hypertension, obstructive sleep apnea, and dyslipidemia as common phenotypic characteristics correlated with diabetes mellitus status. As these phenotypes are usually linked with genetic variants, we hypothesized that these phenotypes share single nucleotide polymorphism (SNP)-clusters that can be used
The present reasoned bibliography was published in Swedish in 1990 as part of a series of reports issued by Linköping University, Arbetsrapporter från Tema Kommunikation, as number 1990:4 in the series. It gained some diffusion among history of photography specialists in the Nordic countries, but was never printed. In the thirty years that have passed since then, no new and comprehensive reasoned
OBJECTIVES: In this study, a systematic analysis was conducted of phasic intracoronary pressure and flow velocity in patients with severe aortic stenosis (AS) and coronary artery disease, undergoing transcatheter aortic valve replacement (TAVR), to determine how AS affects: 1) phasic coronary flow; 2) hyperemic coronary flow; and 3) the most common clinically used indices of coronary stenosis seve
Background: In the standard ECG display, limb leads are presented in a non-anatomical sequence: I, II, III, aVR, aVL, aVF. The Cabrera system is a display format which instead presents the limb leads in a cranial/left-to-caudal/right sequence, i.e. in an anatomically sequential order. Lead aVR is replaced in the Cabrera display by its inverted version, -aVR, which is presented in its logical place
Pain, use of painkillers and alcohol are highly prevalent in the general population. Aims of the study were to describe differences in pain, alcohol consumption and use of painkillers among two 60 year old birth cohorts stratified by gender. Participants were recruited from the Skåne centre of The Swedish National study on Aging and Care, a multicentre, prospective, longitudinal study. The sample
Abstract Background: Advanced paediatric surgery is increasingly centralised in Sweden in order to improve treatment outcomes and reduce surgical risks. However, the overall need for surgery in the paediatric population has not been estimated, and the association between geographic access to surgical facilities and timely treatment for common surgical conditions in children is largely unknown.
The ratio of the cross sections for inclusive isolated-photon production in pp collisions at centre-of-mass energies of 13 and 8 TeV is measured using the ATLAS detector at the LHC. The integrated luminosities of the 13 TeV and 8 TeV datasets are 3.2 fb −1 and 20.2 fb −1 , respectively. The ratio is measured as a function of the photon transverse energy in different regions of the photon pseudorap
Objective: To examine the performance of ultrasound (US) for the diagnosis of gout using the presence of monosodium urate monohydrate (MSU) crystals as the gold standard. Methods: We analyzed data from the Study for Updated Gout Classification Criteria (SUGAR), a large, multicenter observational cross-sectional study of consecutive subjects with at least 1 swollen joint who conceivably may have go
Background: While recent years have seen a revolution in the treatment of metastatic cutaneous melanoma, no treatment has yet been able to demonstrate any prolonged survival in metastatic uveal melanoma. Thus, metastatic uveal melanoma remains a disease with an urgent unmet medical need. Reports of treatment with immune checkpoint inhibitors have thus far been disappointing. Based on animal experi
Background: Total tau (tTau) and phosphorylated 181P tau (pTau) are supportive diagnostic cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease. Manual CSF tau assays are limited by lot-to-lot and between-laboratory variability and long incubation/turnaround times. Elecsys® Total-Tau CSF and Phospho-Tau (181P) CSF immunoassays were developed for fully automated cobas e analyzers, allowing b
α‐Chymotrypsin was adsorbed on solid support materials and the catalytic activity of the preparations in organic solvents was studied. The activity was highly dependent on the nature of the support material and on the amount of water present in the reaction mixture. There appears to be competition for the water in the system between the enzyme, the support material and the solvent. The support mat
Insulin stimulation of adipocytes results in serine phosphorylation/activation of phosphodiesterase 3B (PDE 3B) and activation of a kinase that phosphorylates PDE 3B in vitro, key events in the antilipolytic action of this hormone. We have investigated the role for p70 S6 kinase, mitogen-activated protein kinases (MAP kinases), and protein kinase B (PKB) in the insulin signaling pathway leading to
Introduction Manual interpretation of immunohistochemistry (IHC) is a subjective, time-consuming and variable process, with an inherent intra-observer and inter-observer variability. Automated image analysis approaches offer the possibility of developing rapid, uniform indicators of IHC staining. In the present article we describe the development of a novel approach for automatically quantifying o
The effect of a single washing of the urogenital tract with 0.5 g/l chlorhexidine was studied in 6 women in weeks 38-40 of pregnancy, among whom 5 were carriers of group B streptococci in urethra and/or cervix. The chlorhexidine concentrations varied between 25 and 200 mg/l during the first hour after washing in 5 of the 6 women, whereas one patient showed concentrations below 25 mg/l. With the ex
The direct scattering problem for an inhomogeneous lossy medium is examined for the one-dimensional case in which the phase velocity profile is discontinuous at the boundaries of the medium. Scattering operators (or impulse responses) and propagation operators are defined and equations that govern their behavior are developed. Knowledge of the scattering kernels for one round trip in the medium im
Popular Abstract in Swedish Denna avhandling syftar till att ge en översikt över cirka hundra år av europeisk intellektuell historia som lyfter fram nya aspekter av de klassiska tänkarna. Analysen av de fyra filosoferna Thomas Hobbes, John Locke, David Hume och Charles de Montesquieu syftar till att belysa en generell historisk process, nämligen hur den moderna människosynen växer fram i Europa. EThis essay has three main aims. The first one is to give an overview of some hundred years of European intellectual history, bringing out new aspects of the classical thinkers. The analysis of the four philosophers Thomas Hobbes, John Locke, David Hume and Charles de Montesquieu aims at illustrating a general historical process, viz. the emergence of the modern view of man in Europe. After Hobbes,
Background: Enabling women to make informed decisions is a key objective in the guidelines governing prenatal screening and diagnostics. Despite efforts to provide information, research shows that women's choice of prenatal screening is often not based on informed decisions. The aim of this study was to investigate pregnant women's perceptions of the use of an interactive web-based DA, developed t
This study is devoted to the calibration of a backpack radiation detection system (BPRDS) for evaluation of the external dose to a person staying in an environment contaminated by 137Cs. A commercially available portable gamma-ray spectrometer-dosemeter based on a NaI(Tl) detector was used. By means of information in the pulse-height distribution, it has been possible to separate the technogenic a
