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Hereditary defects of the von Willebrand factor (VWF) gene cause von Willebrand's disease (VWD) which shows great variability dependent on the nature and location of the mutation. We here describe the characteristics of a substitution of methionine for threonine 1156 in the D3 domain of the VWF, i.e. the domain involved in the intracellular multimerization of pro-VWF dimers. A VWD patient withseve
Using a recently introduced multiplex polymerase chain reaction and restriction fragment length polymorphism ABO genotype screening method we have found an anomalous ABO genotype (A2O1variant) not correlating with the serological phenotype (blood group O). The blood group was confirmed by absorption/elution and detection of blood group substances in saliva. Sequencing of exons 6 and 7 in the ABO g
Small modular nuclear reactors (SMRs) are a complex solution for Saskatchewan’s energy transition from fossil fuels to low-carbon sources. As Saskatchewan predominantly relies on fossil fuels for its electricity needs, the consideration of SMRs by SaskPower is in hopes of decreasing carbon emissions and maintaining energy security. SMRs offer several advantages, including modularity, grid stabilit
Mexico City’s water system is not sustainable. There is an unfair inequality gap in the quantity and quality of water access for its residents. Moreover, the groundwater aquifers in the city are being over-exploited and polluted. This has resulted in the sinking of the city, damage to the ecosystems, and the reduction of water access to Mexico City’s residents. As the policies are a direct instrum
Objectives: Romania joined to European Union (EU) in 2007. Consequently, the number of EU citizens of Roma descent increased in Sweden as the movement of freedom was granted. This study attempts to understand the conceptualisation and reason for underreporting hate crimes in Malmö, Sweden. Methods: Qualitative data collection methods of semi-structured interview and participant observation were e
In recent years, the drawbacks of parallel systems in Disaster Risk Reduction (DRR) and Climate Change Adaptation (CCA) have been acknowledged in professional and academic communities, where the need for integration of the two fields in connection to development has been stressed. In this regard, the concept of resilience as an antithesis of risks has also been considered. In this study, a scoping
This thesis is essentially a project in theory- and method-building. It engages the strengths of Vaughan-Williams’ alternative border imaginary under the name of the generalised biopolitical border (GBB) in accounting for the complexity of border phenomena in contemporary global politics. However, it identifies two major shortcomings related to Vaughan-Williams’ application of the GBB to various e
I denna uppsats härleds och testas en ny omviktningsalgoritm med vars hjälp det nativa tillståndet av aminosyresekvenser, bestående av 16 aminosyror, kan förutspås. Algoritmen används till att kartlägga de neutrala näten av α-helixes och β-sheets inom ett kontinuerligt proteinmodell. För att undersöka omviktningsalgoritmens potential för att förutsäga den termodynamiska stabiliteten av olika aminIn this thesis, a new reweighting algorithm for predicting the native conformations of amino acid sequences, consisting of 16 residues in a reduced representation continuous protein model, is derived and tested to map neutral nets of α-helices and β-sheets. For examining the potential of the reweighting algorithm for predicting the thermodynamic stability of amino acid sequences, it is applied to
Cladribine has single-drug activity in acute myeloid leukaemia (AML), and may enhance the formation of the active metabolite (ara-CTP) of cytosine arabinoside (ara-C). To evaluate the feasibility of adding intermittent cladribine to intermediate-dose ara-C (1 g/m(2)/2 h) b.i.d. for 4 d with idarubicin (CCI), we performed a 2:1 randomized phase II trial in AML patients aged over 60 years. Primary e
Many extensions of the Standard Model posit the existence of heavy particles with long lifetimes. In this Letter, results are presented of a search for events containing one or more such particles, which decay at a significant distance from their production point, using a final state containing charged hadrons and an associated muon. This analysis uses a data sample of proton-proton collisions at
The Swedish rules for closely held companies were enacted to combat income conversion abuse in limited liability companies where natural persons acted as both owners and employees. In the Swedish Income Tax Act, employment income is taxed according to a progressive rate while capital income is taxed according to a flat rate. The wage remuneration rule may increase the amount of dividend that the a
This thesis is concerned with history within Nick Clegg’s and Nigel Farage’s political discourse during the six months leading up to the 2016 referendum on the United Kingdom’s membership in the European Union. Using Thematic Analysis combined with Klas-Göran Karlsson’s typology of the use of history, Jörn Rüsen’s typology of historical narrative and drawing on the theoretical framework of histori
The lack of accountability for human rights violations arising out of the activities of multinational enterprises has been identified as a key impediment to the fulfillment of universal human rights and the corresponding access to remedy for victims. However, the last couple of years have witnessed an increasing movement to bridge the accountability gap on the national and international level. Th
Loss of biodiversity is an immediate threat to the planet and if no actions are taken it is expected to accelerate. The highest species richness on smaller scale is found in semi-natural temperate grasslands, with one of the documented records from Stora Alvaret on Öland, Sweden. The area is protected under the Natura 2000-network and Länstyrelsen Kalmar are responsible for monitoring while local
Based on the extensive criticism surrounding the victimization of women in the women, peace and security agenda discourse, this essay seeks to analyze the discourse after the adaption of resolution 2122, a widely recognized step in the direction to focus more on women’s participation. The aim of the study is thus to analyze the discourse around women’s participation and agency on a global and nati
Reindeer husbandry has long been a central element of the traditional livelihood and culture of indigenous Sami people in northern Sweden. However, it faces several challenges from competing land uses, primarily forestry. Different forest conditions are desired by forestry and reindeer husbandry to accommodate each sectors’ distinct interests, promoting high timber and pulp production or improved
Lithuania like other Central and Eastern European (CEE) countries has undergone major changes from the communist socio-economic order to the system based on democratic capitalism. This shift towards market economy and the collapse of communist ideology were also reflected in higher education (HE) reforms. Since political parties are the main actors in modern democracies, partisan politics could in
Around the world, the treatment of food waste is a major administrative and environmental problem throughout the food supply chain. Beijing, as any other mega city, is facing vast issues of sustainable food waste treatment in addition to efforts for food waste reduction. Presently the majority of Beijing's food waste is treated together with the mixed residual waste in landfills (53%) and inci
Chronic wounds are an emerging healthcare issue and current methods of healing chronic wounds address bacteria but are ineffective against resistant bacteria and the biofilm formation commonly observed in these wounds. Antimicrobial peptides (AMPs) derived from the endogenous wound healing system have been shown to combat bacterial infections, exhibit immunomodulatory effects, as well as improvi
Titel: Hur verkligt är verkligt värde? En studie om underprissättning vid börsintroduktioner Seminariedatum: 2 juni 2023 Kurs: FEKH69 – Examensarbete i redovisning på kandidatnivå Författare: Oskar Brunnéd, Simon Sandström, Jamal Shamma Handledare: Liesel Klemcke Syfte: Studien syftar till att undersöka ifall underprissättningen vid börsintroduktioner på Stockholmsbörsen och Nordic Growth Ma
