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In the intestinal tract, there are enzymes that hydrolyze both endogenous and exogenous sphingolipids. The alkaline sphingomyelinases (SMase) of the gut and human bile have been most studied, and a major part of this chapter discusses these enzymes. It also discusses studies of ceramidase, glycosylceramidase, and the digestion of dietary sphingolipids. In the intestinal tract, a distinct enzyme th
Artificial intelligence (AI) algorithms for automated classification of skin diseases are available to the con-sumer market. Studies of their diagnostic accuracy are rare. We assessed the diagnostic accuracy of an open-access AI application (Skin Image Search™) for recognition of skin diseases. Clinical images including tumours, infective and inflammatory skin diseases were collected at the Depart
The four-lepton (4ℓ, ℓ=e,μ) production cross section is measured in the mass range from 80 to 1000 GeV using 20.3 fb−1 of data in pp collisions at s=8 TeV collected with the ATLAS detector at the LHC. The 4ℓ events are produced in the decays of resonant Z and Higgs bosons and the non-resonant ZZ continuum originating from qq¯, gg, and qg initial states. A total of 476 signal candidate events are o
Popular Abstract in Swedish Prosodi och intonation är viktiga delar i det mänskliga talet. I system för text-till-talomvandling och automatisk taligenkänning måste prosodiska modeller inkluderas för att uppnå acceptabla resultat. Denna avhandling bidrar till modelleringen av svensk prosodi ur lexikalt och akustiskt perspektiv. Tre aspekter av lexikal modellering av prosodi studeras. Vi skisserar Prosody and intonation are very important ingredients of human speech. In speech technology, text-to-speech (TTS) and automatic speech recognition (ASR) systems must incorporate prosodic models in order to reach acceptable performances. We contribute to the modelling of Swedish prosody in a speech technology context from lexical and acoustic angles. Three aspects of lexical prosodic modelling are
In May 2005, visceral leishmaniasis (VL) was recognized for the first time in Libo Kemkem, Ethiopia. In October 2005, a rapid assessment was conducted using data from 492 patients with VL treated in the district health center and a household survey of 584 residents of four villages. One subdistrict accounted for 71% of early cases, but the incidence and number of affected subdistricts increased pr
The catanionic system didodecyldimethylammonium bromide (DDAB)-sodium taurodeoxycholate (STDC)-D2O is characterized by an exceptionally extended L1 region. The comparison of self-diffusion coefficient of the solvent and the DDAB embedded in the micelles provided information about hydration of the aggregates. Moreover, correlating self-diffusion and 14N NMR relaxation measurements new insight could
In the study of the odd-Z, even-N nuclei Es243 and Md249, performed at the University of Jyväskylä, the fusion-evaporation reactions Au197(Ca48,2n)Es243 and Tl203(Ca48,2n)Md249 have been used for the first time. Fusion-evaporation residues were selected and detected using a gas-filled separator coupled with its focal-plane spectrometer. For Es243, the recoil decay correlation analysis yielded a ha
We study the scaling properties of the differential cross section of elastic proton–proton (pp) and proton–antiproton (pp¯) collisions at high energies. We introduce a new scaling function, that scales – within the experimental errors – all the ISR data on elastic pp scattering from s=23.5–62.5 GeV to the same universal curve. We explore the scaling properties of the differential cross-sections of
A growing body of evidence points out the potential role of inflammatory mechanisms in the pathophysiology of brain damage in dementia. We have recently demonstrated that patients with Alzheimer's disease (AD) and vascular dementia (VaD) display an intrathecal production of proinflammatory cytokines. TNF-alpha, one of these cytokines, leads to the production of nitric oxide (NO), a potent inflamma
Disease gene identification is still a challenge despite modern high-throughput methods. Many diseases are very rare or lethal and thus cannot be investigated with traditional methods. Several in silico methods have been developed but they have some limitations. We introduce a new method that combines information about protein-interaction network properties and Gene Ontology terms. Genes with high
Sclerosing injections under ultrasonographic guidance is a new method of treatment for persistent pain in Achilles tendinosis. Good results, even superior to those of surgery, have been described. We report the outcome of 25 patients with midportion tendinosis receiving sclerosing treatment. Twenty-eight consecutive patients (29 tendons) with ultrasonographical findings of midportion tendinosis ex
Droughts affect ecosystems at multiple time scales, but their sub-seasonal legacy effects on vegetation activity remain unclear. Combining the satellite-based enhanced vegetation index MODIS EVI with a novel location-specific definition of the growing season, we quantify drought impacts on sub-seasonal vegetation activity and the subsequent recovery in the Northern Hemisphere. Drought legacy effec
We celebrate Govindjee, Professor Emeritus of Plant Biology, Biochemistry, and Biophysics, University of Illinois at Urbana-Champaign, on the occasion of his 90th birthday. He is renowned for his pioneering work in the discovery of the two-light reactions and two photosystems, PSI and PSII, leading to the Z-scheme of the electron transport chain; and for breakthrough advances in oxygenic photosynt
