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Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix. Recently we reported that EDC34, a C-terminal peptide derived from TFPI-2, exerts a broad antimicrobial activity. In the present study, we describe a previously unknown antimicrobial mode of ac
Introduction: Recent haemophilia treatment advances include new recombinant FVIII (rFVIII) products with improved pharmacokinetic (PK) properties that aim to reduce the burden of prophylaxis. These treatments are commonly referred to as extended half-life rFVIII products (EHL rFVIII). There is no uniform definition of what constitutes an EHL rFVIII. Such a definition would help physicians, patient
IgA nephropathy (IgAN) and Henoch-Schönlein purpura (HSP) are diseases characterized by IgA deposits in the kidney and/or skin. Both may arise after upper respiratory tract infections, but the pathogenic mechanisms governing these diseases remain unclear. Patients with IgAN (n = 16) and HSP (n = 17) were included in this study aimed at examining whether IgA-binding M proteins of group A streptococ
Of 30 bacterial species tested 18 stimulated DNA synthesis in human blood lymphocytes. The maximum response was after 3-4 days of culture suggesting a mitogenic effect. This was confirmed by the induction of polyclonal antibody production shown by a plaque assay. Most bacterial species increased the DNA synthesis in B-enriched lymphocytes and unseparated lymphocytes but had negligible activity on
Background: Nigeria is a major contributor to the global malaria burden. The genetic diversity of malaria parasite populations as well as antibody responses of individuals in affected areas against antigens of the parasite can reveal the transmission intensity, a key information required to control the disease. This work was carried out to determine the allelic frequency of highly polymorphic Plas
Background: 4-1BB (CD137) is a co-stimulatory receptor highly expressed on tumor reactive effector T cells and NK cells, which upon stimulation prolongs persistence of tumor reactive effector T and NK cells within the tumor and induces long-lived memory T cells. 4-1BB agonistic antibodies have been shown to induce strong anti-tumor effects that synergize with immune checkpoint inhibitors. The firs
The intense debate on continuity in child grammars has largely focused on the existence of Functional Categories (FCs) in early grammars despite differences in language use with adults (e.g., omissions, word order errors, lack of case marking). Simplified, the major theoretical explanations for these properties range from Maturational accounts (Radford 1990 and later) claiming an initial absence o
CAMBODIA NATIONAL LAW AND POLICY REPORT CONSULTATION DRAFT 2020 Displacement in the Context of Disasters and Climate Change Funded by This report was prepared by Victor Bernard (RWI) and Matthew Scott (RWI) 2020 TABLE OF CONTENTS 1 INTRODUCTION 1 1.1. A human rights-based approach 1 2 Displacement in Numbers 3 2.1. Number of disasters and people affected in the last ten years (2009–2018) 3 3 Recom
https://rwi.lu.se/wp-content/uploads/2024/03/Consultation-Draft_Cambodia.pdf - 2026-07-03
MSH2 rearrangements are involved in approximately 10% of hereditary non,polyposis colorectal cancer (HNPCC) families, and in most of the rearrangements, exon I is deleted. We scanned by quantitative multiplex polymerase chain reaction (PCR) of short fluorescent fragments (QMPSF) 200 kb of genomic sequences upstream of the MSH2 transcription initiation site in 21 HNPCC families with exon I deletion
Sweden was the first country in the world to introduce rules on transparency in public activities - the principle of public access to official records was introduced as early as 1766 as part of the Freedom of the Press Act of 1766. This legislation, which was unique at the time, has since meant that Sweden has had public access to official records and transparency as the main rule for public activSweden was the first country in the world to introduce rules on transparency in public activities - the principle of public access to official records was introduced as early as 1766 as part of the Freedom of the Press Act of 1766. This legislation, which was unique at the time, has since meant that Sweden has had public access to official records and transparency as the main rule for public activ
Översikt över hur universitetsjubileerna 1768, 1868, 1918 och 1968 speglat sin tid, bedömts av samtida betraktare och de mer konkreta spår de efterlämnat.
Background. Anti-glomerular basement membrane (anti-GBM) disease often results in end-stage renal failure despite therapy with plasma exchange and immunosuppressive drugs. The newly discovered streptococcal enzymes IgG-degrading enzyme of S.pyogenes (IdeS) and endoglycosidase S (EndoS) act with remarkable specificity on circulating IgG. In this study, we investigate their ability in vivo to preven
The function of cultured mast cells may depend on genetic or environmental influence on the stem cell donor. This study investigates whether asthma or atopy in the donor influenced the growth and sensitivity of mast cells cultured from patients with asthma and healthy controls under identical conditions. Mast cells were cultured from peripheral blood from twelve patients with an objectively confir
