Filtyp
Background: High expression of the polymeric immunoglobulin receptor (PIGR) has previously been associated with a favourable prognosis in a few cancer forms, but its expression and relationship with clinical outcome in epithelial ovarian cancer (EOC) has not yet been reported. The aim of this study was therefore to examine the clinicopathological correlates and prognostic significance of PIGR expr
Background: Metabolic syndrome (MetS) remains a controversial entity. Specific clusters of MetS components - rather than MetS per se - are associated with accelerated arterial ageing and with cardiovascular (CV) events. To investigate whether the distribution of clusters of MetS components differed cross-culturally, we studied 34,821 subjects from 12 cohorts from 10 European countries and one coho
Background: Topical negative pressure (TNP), widely used in wound therapy, is known to stimulate wound edge blood flow, granulation tissue formation, angiogenesis, and revascularization. We have previously shown that application of a TNP of -50 mmHg to the myocardium significantly increases microvascular blood flow in the underlying tissue. We have also shown that a myocardial TNP levels between -
Background: Currently available biomarkers for the early tissue process leading to joint damage in rheumatoid arthritis are insufficient and lack prognostic accuracy, possibly a result of variable activity of the disease over time. This study represents a novel approach to detect an altered activity of the disease process detected as increasing serum-COMP levels over a short time and whether this
To identify prognostic factors after hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). We retrospectively reviewed the combined experience at Toronto General Hospital and Hospital Vall d'Hebron managing HCC recurrence after LT (n = 121) between 2000 and 2012. We analyzed prognostic factors by uni- and multi-variate analysis. Median follow-up from LT was 29.5 (range 2-129.
Purpose: The purpose of this work was to evaluate the visibility of simulated lesions in 2D digital mammography (DM) and breast tomosynthesis (BT) images of patients. Methods: Images of the same women were acquired on both a DM system (Mammomat Novation, Siemens Healthcare, Erlangen, Germany) and a BT prototype system adapted from the same type of DM system. Using the geometrical properties of the
Autochthonous blockfield mantles may indicate alpine surfaces that have not been glacially eroded. These surfaces may therefore serve as markers against which to determine Quaternary erosion volumes in adjacent glacially eroded sectors. To explore these potential utilities, chemical weathering features, erosion rates, and regolith residence durations of mountain blockfields are investigated in the
Objective To compare drug survival on adalimumab, etanercept and infliximab in patients with rheumatoid arthritis (RA). Methods Patients with RA (n=9139; 76% women; mean age 56 years) starting their first tumour necrosis factor (TNF) inhibitor between 2003 and 2011 were identified in the Swedish Biologics Register (ARTIS). Data were collected through 31 December 2011. Drug survival over up to 5 ye
Objective To investigate the possible association of the BANK1 gene with genetic susceptibility to systemic sclerosis (SSc) and its subphenotypes. Methods A large multicentre case-control association study including 2380 patients with SSc and 3270 healthy controls from six independent case-control sets of Caucasian ancestry ( American, Spanish, Dutch, German, Swedish and Italian) was conducted. Th
In this thesis we discuss and test ways to improve the performance of inline integration. Inline integration is a tool used for real-time simulations of complex dynamical systems. The idea is to relate information about the system to the numerical method at a model level. Real-time simulations of complex models have become standard in industry. This puts high demands on simulation tools with regar
This thesis investigates the development of labor market policies directed at immigrants in Sweden, during the period of 1968-2010. The theoretical framework is built around three distinct ideas concerning the concept of citizenship – one libertarian, one empowering and a last one called caring, in the sense that it emphasizes the responsibility of society. My material consists of government publi
Popular summary The fate of non-steroidal anti-inflammatory drugs The knowledge about distribution of drugs between sewage sludge, water phases and water living organisms is vital for predictions of the fate and transport routes of toxic substances to the environment. And the distribution of drugs in the environment can be used as a base for risk assessments and it also can be used to define desir
Populärvetenskaplig sammanfattning: Är klimatforskningen skev? En central fråga är om vi kan lita på att vetenskapliga tidskrifter återger en rättvis bild av aktuella forskningsresultat? Dessutom bör vi fråga oss hur rapporteringen påverkas då betydande händelser sker inom vetenskapsvärlden. I november 2007 och senare 2009 skedde två viktiga företeelser inom klimatforskningen som potentiellt kanAbstract The declaration of a scientific consensus concerning anthropogenic causes for climate change by the IPCC in their fourth assessment report (AR4), published in 2007, initiated a heated debate. During this debate, experts within the IPCC were accused of selective reporting and the AR4 got strong source criticism by politicians, stakeholders and climate skeptics in general. The debate furth
Lund's Climate Alliance was initiated 2010 by the municipality of Lund, in southern Sweden, to support local climate adaptation and mitigation efforts. The purpose of this paper is to investigate what each member of Lund's Climate Alliance believes will be necessary to realize sustainability goals particular to their organization in the future. The study thereby points to new topics, activ
The main aim of this paper is to seek to understand how incubators within the entrepreneurial ecosystem in Skåne interact and engage with startups, and looks to address three secondary research questions expanding on the subject. Three semi-structured interviews were conducted with sustainability and business development representatives of incubators in Skåne in order to gain insight into methods
The wind power industry has long remained passive on broader sustainability issues, grounded in the perception that the industry is inherently linked with environmental sustainability. Within the past 5 years, there has been a dramatic change in the stakeholder and corporate perception of sustainability. Increasing expectations from stakeholders are pressuring wind OEMs to transition and advance c
Tidigare studier har visat att konstruktionen med platta på mark av trä uppfyller förväntade tekniska och miljömässiga egenskaper som kan förväntas av en grundläggning i allmänhet och av ett mer klimatneutralt material. Konstruktionen bedöms även vara konkurrenskraftig både i tillverkning och kostnad vid jämförelse med konventionella metoder. Småhustillverkare ser generellt positivt på produkten, Previous studies have shown that a construction of a slab foundation of wood meets the expected technical and environmental characteristics that can be expected from a foundation in general and from a more climate-neutral material. The design is also considered to be competitive both in manufacturing and cost when compared with conventional methods. Single-family home manufacturers generally view
The present thesis explores perceptions about if and how are the EU norms adopted, adapted, resisted or rejected in the case of Kosovo. Moreover, a comparison between two parts within Kosovo will be conducted: a northern part with Serbian majority and the "rest of Kosovo" with Albanian majority. The objective is to investigate the effect of the EU normative power in different parts of a
