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The positive association between social capital and general health outcomes has been extensively researched over the past decade; however, studies investigating social capital and psychological health show less consistent results. Despite this, policy-makers worldwide still employ elements of social capital to promote and improve psychological health. This United Kingdom study investigates the ass
Cholera toxin (CT) binds to GM1-ganglioside receptors present on all nucleated cells. Despite this, it is a very potent mucosal adjuvant that has a dramatic impact on immune cells, as well as nerve and epithelial cells, causing diarrhea. This fact has hampered our understanding of whether the adjuvanticity of CT is direct or indirect, as cells that bind CT may or may not be involved in its adjuvan
Popular Abstract in English Background Palliative care is an approach characterized by a holistic view of the person, which supports the individual for living with dignity and with the best possible level of wellbeing until the end of life. Earlier studies have shown that older people do not have the same access to palliative care as younger people do. One reason for this could be that it is diffiThe aim of this thesis was to study nurse assistants’ experience of palliative care and to investigate how an intervention with a focus on a palliative care approach in residential care facilities influenced the nurse assistants and their work situation. The thesis is based on two qualitative and two quantitative studies, focusing on nurse assistants working at residential care facilities for olde
Background: Therapeutic fluids used in intensive care can have profound effects on coagulation, not only by dilution itself but also by other more complicated interactions. The aim of this in vitro study was to monitor the extent of dilutive coagulopathy induced by the most common therapeutic fluids and to attempt normalization of haemostasis by fibrinogen addition. Methods: 8 patients were re
Decomposition of organic matter in high latitude biomes makes a significant contribution to global fluxes of nutrients and carbon and is expected to accelerate due to climate change. The majority of studies have focused on decomposition during the growing season, but winter climate is expected to change dramatically. Furthermore, knowledge of the drivers of organic matter decomposition, such as li
Comparison between growth variability, based on ring-width (RW) analysis, and moisture-sensitive signals in tree-ring carbon and oxygen stable-isotope composition provides increased understanding of how climate and hydrology influenced bog pines (Pinus sylvestris L) at two sites in southern Sweden during the mid- and late Holocene. Tree-ring sequences from two subfossil trees collected at raised b
This paper presents a mathematical approach and numerical model that simulates beach and dune change in response to cross-shore processes of dune growth by wind and dune erosion by storms, and by gradients in longshore sand transport that will alter shoreline position. Sub-aerial transport processes are represented, whereas sub-aqueous transport is neglected. The system is tightly coupled morpholo
Med den globala uppvärmningen förutspås klimatet i arktiska och subarktiska miljöer förändras påtagligt. Enligt IPCCs senaste rapport kan både temperatur och nederbörd öka dubbelt så mycket som det globala genomsnittet, och störst ökning väntas under vinterhalvåret. Många känsliga ekosystem och miljöer kommer med stor sannolikhet att påverkas redan vid små förändringar. Ett exempel på sådana miljöThe on-going global warming is projected to have large impacts on the arctic and subarctic environment. Especially vulnerable are ecosystems with narrow climatic envelopes and with small possibilities of adaptation. An example of this is the palsa mires, subarctic mire complexes with patches of permafrost. Palsas are peat mounds with a frozen core, formed by the expansion and upheaval of the segre
After identifying an association between maternal Epstein-Barr virus (EBV) reactivation and acute lymphoblastic leukemia (ALL), the authors analyzed a nested case-control study within Finnish and Icelandic maternity cohorts with 7 million years of follow-up to confirm EBV's role in ALL. Offspring of 550,000 mothers were followed up to age 15 years during 1975-1997 by national cancer registries to
Recent measurements of collective effect-like signals in small collision systems has highlighted the need for new models to explain these phenomena. One good candidate for such a model is the AMY QCD effective kinetic theory, which is valid for systems in- and out-of-equilibrium. This thesis is a collection of four papers which all investigate how to apply AMY kinetic theory to explain the evoluti
Background: The use of chat-based digital visits (eVisits) to assess infectious symptoms in primary care is rapidly increasing. The "digi-physical" model of care uses eVisits as the first line of assessment while assuming a certain proportion of patients will inevitably need to be further assessed through urgent physical examination within 48 h. It is unclear to what extent this approach can mitig
Data from field experiments carried out in the swash zone on two Pacific beaches in Japan were analyzed to determine net sediment transport rates and the resulting foreshore response. The experiments involved artificial modification of the foreshore slope with a bulldozer, either making the slope steeper or milder, after which a wide range of measurements were performed as the slope evolved back t
Although long-acting inhaled beta(2)-agonists improve various outcome measures in COPD, no double-blind study has yet shown a significant effect of these drugs on exercise capacity. In a randomized, double-blind, placebo-controlled, crossover study, patients received formoterol (4.5,9, or 18 mug b.i.d via Turbuhaler(R)), ipratroplum bromide (80 mug t.i.d via pMDI with spacer), or placebo for I wee
A sensitive biosensor has been developed for the neurotoxin beta-N-oxalyl-alpha,beta-diaminopropionic acid (beta-ODAP) contained in the seeds of grass pea (Lathyrus sativus) and for L-glutamate based on glutamate oxidase (GlOx) and a Prussian blue (PB) modified glassy carbon (GC) electrode. The configuration of the system is so as to detect the hydrogen peroxide released during the enzymatic cycle
In previous studies, glucagon receptor knockout mice (Gcgr(-/-)) display reduced blood glucose and increased glucose tolerance, with hyperglucagonemia and increased levels of glucagon-like peptide (GLP)-1. However, the role of glucagon receptor signaling for the regulation of islet function and insulin sensitivity is unknown. We therefore explored P-cell function and insulin sensitivity in Gcgr(-/
The p53 tumor suppressor gene regulates growth arrest and apoptosis after DNA damage. Recent studies suggest that p53 is inactive in vascular smooth muscle cells (VSMCs) in human angioplasty restenosis, promoting VSMC accumulation and vessel stenosis. In contrast, the success of irradiation (brachytherapy) for in-stent restenosis argues that DNA-damage p53 responses are intact. We examined p53 exp
In this paper, it is demonstrated that a single-receptor biosensor can be used to quantitatively determine each analyte in binary Mixtures LIS in multivariate data analysis tools based on the dynamic responses received from flow injection peaks. Mixtures with different concentrations of two phenolic compounds, catechol and 4-chlorophenol, were measured with a graphite electrode modified with tyros
