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Baker´s yeast S. cerevisiae has been engineered in order to enable xylose uptake and utilization from lignocellulosic biomass as this yeast cannot naturally metabolize this pentose sugar. However, xylose is not recognized as a fermentable sugar by S. cerevisiae and recent studies on the effect of xylose on the three main sugar signaling pathways (Snf3p/Rgt2p, SNF1/Mig1pt and cAMP/PKA) have indicat
Popular science summary Comparison of ectoparasite load on barnacle geese (Branta leucopsis) in arctic and temperate regions Some birds winter in warm regions, but breed in the arctic. This long migration takes up a lot of energy, which leaves scientists wonder why birds undertake this journey. One of the many hypotheses to explain it, is that there are fewer parasites in the arctic. Therefore,
Objectives: The aim of this study was to investigate the influence of specific components of Andersen's behavioural model on adult individuals' perceived oral treatment need. Methods: A questionnaire was sent to a randomly selected sample of 9,690 individuals, 20 to 89 years old, living in Skane, Sweden. The 58 questions, some with follow-up questions, were answered by 6,123 individuals; a 63% res
Aims. The present study was conducted to determine the optical extinction curve for Cerro Paranal under typical clear-sky observing conditions, with the purpose of providing the community with a function to be used to correct the observed spectra, with an accuracy of 0.01 mag airmass(-1). Additionally, this work was meant to analyze the variability of the various components, to derive the main atm
Background: This phase II study evaluated the safety and activity of ipilimumab, a fully human mAb that blocks cytotoxic T-lymphocyte antigen-4, in patients with advanced melanoma. Patients and methods: Patients with previously treated, unresectable stage III/stage IV melanoma received 10 mg/kg ipilimumab every 3 weeks for four cycles (induction) followed by maintenance therapy every 3 months. The
Among heavy-fermion metals, Ce3Pd20Si6 is one of the heaviest-electron systems known to date. Here we used high-resolution neutron spectroscopy to observe low-energy magnetic scattering from a single crystal of this compound in the paramagnetic state. We investigated its temperature dependence and distribution in momentum space, which was not accessible in earlier measurements on polycrystalline s
“Netflix and chill?” It has been 10 years since this phrase has become an innuendo for casual sex. Netflix has become a streaming titan with over 300 million subscribers. The success of Netflix owes much to its original contents emphasising the competitive edge. Netflix categories its soft-core porn titles as Steamy Movies on the platform and even has an established category code for the genre, 11
Food insecurity is a reality faced by millions of people worldwide. Poor access and availability to food markets, poverty, and uncertain global system futures all exacerbate this issue. In seeking to combat food insecurity for South Carolina residents and improve the viability and resilience of local food markets around Greenville County, South Carolina, this assessment determines optimal potentia
Title: “Language is access to everything” - A qualitative study of SFI-teachers' experience of the transition to digitalized distance education. Authors: Rania Elwan and Fitore Mehmeti Supervisor: Karin Kullberg Assessor: Maria Bergendal Arvidsson The purpose of the study is to investigate from teachers for Swedish for immigrants (SFI) perspective how the transition to digitalized distance ed
The therapeutic landscape of chronic myeloid leukemia (CML) has profoundly changed over the past 7 years. Most patients with chronic phase (CP) now have a normal life expectancy. Another goal is achieving a stable deep molecular response (DMR) and discontinuing medication for treatment-free remission (TFR). The European LeukemiaNet convened an expert panel to critically evaluate and update the evi
Background: Therapeutic fluids used in intensive care can have profound effects on coagulation, not only by dilution itself but also by other more complicated interactions. The aim of this in vitro study was to monitor the extent of dilutive coagulopathy induced by the most common therapeutic fluids and to attempt normalization of haemostasis by fibrinogen addition. Methods: 8 patients were re
Popular Abstract in Swedish Nivån på arbetsproduktivitet är särskilt betydelsefull i utvecklingsländer där det mesta av byggnadsarbetet utförs manuellt. Tidigare forskning har konstaterat att produktiviteten i byggindustrin är låg och i några fall sjunkande. Bristande produktivitet hos byggnadsarbetarna är en orsak till kostnadsöverskridande och förseningar av byggprojekt. Syfte med detta forskninProductivity of labour is particularly important especially in developing countries where most of the building work is still carried out on manual basis. Previous research has pointed out that productivity in the building industry is low and in some cases declining. Poor productivity of craftsmen is one of the causes of cost and time overruns on building projects. The objective of this research wa
Decomposition of organic matter in high latitude biomes makes a significant contribution to global fluxes of nutrients and carbon and is expected to accelerate due to climate change. The majority of studies have focused on decomposition during the growing season, but winter climate is expected to change dramatically. Furthermore, knowledge of the drivers of organic matter decomposition, such as li
The p53 tumor suppressor gene regulates growth arrest and apoptosis after DNA damage. Recent studies suggest that p53 is inactive in vascular smooth muscle cells (VSMCs) in human angioplasty restenosis, promoting VSMC accumulation and vessel stenosis. In contrast, the success of irradiation (brachytherapy) for in-stent restenosis argues that DNA-damage p53 responses are intact. We examined p53 exp
In this paper, it is demonstrated that a single-receptor biosensor can be used to quantitatively determine each analyte in binary Mixtures LIS in multivariate data analysis tools based on the dynamic responses received from flow injection peaks. Mixtures with different concentrations of two phenolic compounds, catechol and 4-chlorophenol, were measured with a graphite electrode modified with tyros
Data from field experiments carried out in the swash zone on two Pacific beaches in Japan were analyzed to determine net sediment transport rates and the resulting foreshore response. The experiments involved artificial modification of the foreshore slope with a bulldozer, either making the slope steeper or milder, after which a wide range of measurements were performed as the slope evolved back t
Cholera toxin (CT) binds to GM1-ganglioside receptors present on all nucleated cells. Despite this, it is a very potent mucosal adjuvant that has a dramatic impact on immune cells, as well as nerve and epithelial cells, causing diarrhea. This fact has hampered our understanding of whether the adjuvanticity of CT is direct or indirect, as cells that bind CT may or may not be involved in its adjuvan
