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We studied the effect of pilocarpine hydrochloride, a parasympathicomimewtic agent, on major salivary gland output and subjective responses in 40 patients with salivary hypofunction. Pilocarpine increased salivary output or gave significant symptomatic relief in 21 of the 40 patients. The women fared better than the men. Side effects were uncommon, were generally mild, and caused no treatment inte
Pollen analyses and AMS C-14 measurements were performed on lacustrine sediments and peat sequences from two former crater lakes (Preluca Tiganului, Steregoiu) situated in the Gutaiului Mountains in northwestern Romania, in order to reconstruct the vegetation development during the Lateglacial and Early Holocene. Before c. 14,700 cal. years BP (GS-2) open vegetation with shrubs (Salix, Juniperus),
Popular Abstract in Swedish Vårt immunsystem har utvecklats för att skydda våra vävnader och organ vid infektioner, cancerväxt och andra skador. Immunsystemet utgörs av en mängd olika celltyper som på olika sätt specifikt, främst genom uttryck av receptorer på cellytan, reagerar på främmande strukturer, från t ex patogener eller tumör celler eller andra substanser som signalerar stress eller fara.This thesis is based on three original papers with the overall aim to study the mechanisms of induction and function of Foxp3+CD4+CD25+ regulatory T cells. Regulatory T cells induce down-modulation of costimulatory molecules CD80 and CD86 on dendritic cells in vitro. In the first study we further show that the extent of down-modulation is functionally significant since regulatory T cell condition
Human liver alpha-L-fucosidase (alpha-L-fucoside fucohydrolase, EC 3.2.1.51) has been separated into four components by chromatography on Sephadex G-150 or DEAE-cellulose. These components differ in their relative stability to heat and acid treatment, and their response to neuraminidase. The serum enzyme was devoid of high molecular weight activity and probably contained more sialic acid residues
Acute lymphoblastic leukemia (ALL) is the major pediatric cancer diagnosed in economically developed countries with B-cell precursor (BCP)-ALL, accounting for approximately 70% of ALL. Recent genome-wide association studies (GWAS) have provided the first unambiguous evidence for common inherited susceptibility to BCP-ALL, identifying susceptibility loci at 7p12.2, 9p21.3, 10q21.2, and 14q11.2. To
Objective: The longitudinal epidemiological development of the new variant of Chlamydia trachomatis was studied after appropriate testing procedures had been introduced when the strain was detected in 2006. Methods: The number of cases of the new variant of C trachomatis was followed from 2007 through 2011 from the laboratory records. Testing for C trachomatis is centralised to one laboratory wit
Popular Abstract in Swedish Även om vi i dagens samhälle försöker minska vårt beroende av förbränningsprocesser är förbränning fortfarande vår största energikälla och förväntas så förbli under en lång tid. Därför är det viktigt att effektivisera förbränningsprocesserna för att maximera den energi som utvinns medan utsläppen samtidigt minimeras. En av de oönskade biprodukterna vid förbränning är soThis work has been aimed at developing and applying laser-induced incandescence (LII) for flame soot characterization. The basic principle of LII is rapid heating of the soot particles to temperatures of 3500-4000 K by short laser pulses. Thereby the intensity of the soot incandescence is increased. By detection of this increased incandescence and analysis of the detected signal, the volume fracti
Low-energy electron diffraction, scanning tunneling microscopy, and photoelectron spectroscopy results from the submonolayer Sm- and Yb-induced surface structures are presented. Several similar metal-induced surface reconstructions are found to exist for Yb and Sm on Si(111) for low submonolayer coverages: 3×2, 5×1, and 7×1. At higher submonolayer coverage, Yb induces a 2×1 reconstruction while Sm
Biorefineries have the potential to partially or entirely replace petrochemistry for the production of our daily bulk and fine chemicals. However, this replacement can only be sustainable and cost-effective if the raw material used is cheap, renewable and does not compete with the food and feed industry. One raw material meeting these criteria is lignocellulose from agricultural and forestry waste
The host response to immunologically incompatible intrastriatal neural grafts was studied using immunohistochemical techniques. Dissociated ventral mesencephalic tissue from embryonic donors of either syngeneic, allogeneic or xenogeneic (mouse) origin was stereotaxically implanted into adult rats. The brains were analysed 4 days, 2 weeks or 6 weeks after grafting with antibodies against the follow
Inom beredskapen mot radiologiska och nukleära olyckor och katastrofer spelar strålningsmätningar en avgörande roll för att ta reda på vad som har hänt och hur farligt det är för människa, djur och natur och på vilket sätt det påverkar miljö och samhällsfunktioner. I Sverige och många andra länder i världen har allmänheten en rättighet att få reda på vad som hänt och vad de utsätts för i ett eventThis thesis describes investigations made on mobile and stationary gammaspectrometry made both under laboratory conditions and in situ. The objective hasbeen to identify and quantify radionuclides in the form of point sources,contamination and widespread deposition in situations where the measurementgeometry is not known beforehand. Both scintillators and semiconductor detectors ofsimilar size wer
In recent years, newly arrived students have been in focus in Swedish education, for example, because of the large number of asylum seekers to Sweden which has become a challenge for the Swedish school system (Swedish Schools Inspectorate, 2015). But also because of recent changes in the Education act whereby time spent in reception classes was to be reduced for newly arrived students and they sha
The objective of this thesis is to investigate the synthesis of well-defined polymer nanohybrid materials bearing desirable functionality via surface-initiated atom transfer radical polymerization (SI-ATRP) for potential bioapplications.SI-ATRP is an excellent controlled radical polymerization (CRP) method for the synthesis of polymer nanohybrid by growing polymer brushes (chains) from an interfac
The objective of this article is to amalgamate previous results into a speculative synthesis that sheds light on the causes of secondary brain damage following either global/forebrain or focal ischemia. The hypothesis is based on the well-founded assumption that the pathophysiology of the brain damage incurred by global or forebrain ischemia is different from that of focal ischemia. In the former,
Magnetic resonance imaging (MRI) permits the visualization of anatomical structures not appreciated by conventional radiographic imaging, and may assess inflammatory disease and its progression with greater sensitivity than conventional radiography. In this study of 30 patients with early rheumatoid arthritis (RA), which could be considered as a pilot study because of the relatively small number o
2021 marked the 30-year anniversary of the publication Fatal Years: Child Mortality in the late Nineteenth-Century United States, a pioneering work in historical demography by Samuel H. Preston and Michael R. Haines. This special issue showcases the current state of historical mortality studies through a collection of articles originally presented at two commemorative sessions at the 2021 meeting
