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Background: Interactions between Th1 and Th2 immune responses are of importance to the onset and development of allergic disorders. A Toll-like receptor 7 agonist such as AZD8848 may have potential as a treatment for allergic airway disease by skewing the immune system away from a Th2 profile. Objective: To evaluate the efficacy and safety of intranasal AZD8848. Methods: In a placebo-controlled si
The pharmaceutical industry uses animal models in a variety of settings including safety, pharmacodynamic modelling and efficacy. Conventionally, a frequentist design of standard animal experiments of human asthma replication includes repeatedly running treatment groups with the exact layout, focusing on effect size rather than capturing historical data of animal responses on compounds of interest
Bakgrund: Kulturhistoriska byggnader har ett särskilt historiskt, estetiskt eller socialt värde och skyddas av regler som begränsar förändringar. Med rätt byggnadsvård och tekiska lösningar kan bevarande kombineras med energieffektiviseringar. Även om bevarande ofta innebär högre initiala kostnader, kan det ge långsiktiga värden både kulturellt och ekonomiskt. Syfte: Syftet är ett undersöka hur kThroughout history, construction practices have reflected the materials, knowledge, and economic resources available at the time. These historical characteristics are now seen as cultural assets worth preserving. However, older buildings often fail to meet modern standards, necessitating significant interventions to comply with today’s regulations. This thesis explores the challenges and opportun
Several studies have reported a declining reading rate in school-aged children. Thus, this thesis therefore aimed to evaluate how students in their last semester of high school (gymnasiet) would have their attentive behaviour affected when reading challenging texts, and with the allowance or the prohibition of the use of electronic devices in the classroom. The purpose of the study was to foster a
Online shopping is gradually becoming a daily behavior in people's lives, and advertising marketing methods based on short videos are also playing an increasingly important role in this trend. Different from pictures and texts, it combines sound and picture, is easy to spread, and contains a lot of information, which conforms to people's habit of using fragmented information. In this case,
Autism spectrum disorder (ASD) is a neuropsychiatric condition containing a large spectrum of developmental disorders. The diagnosed condition is increasing among people today. With this in mind, there is also a growing need for competence and experience with services and organizations providing care for this target group. The aim of this study was therefore to examine what competence and experien
I november 2021 beslutade den dåvarande regeringen att tillsätta en utredning för att göra en översyn av regleringen om frihetsberövande påföljder för unga. I augusti 2023 publicerades utredningen som ställer sig positiv införandet av s.k. ungdomsfängelser. Den frihetsberövande påföljd som i nuläget finns för unga lagöverträdare (15–17 år), utöver fängelse, är sluten ungdomsvård (och stadgas i 32 In November 2021, the Swedish government at the time decided to appoint an inquiry to review the regulations on custodial sanctions for young people. In August 2023, the investigation was published, which is in favor of juvenile prisons. The custodial sanction that currently exists for young offenders (15-17 years old), in addition to imprisonment, is "closed youth care" (and is stipulat
Vårdnadsreglerna, framför allt regleringen om gemensam vårdnad, har gjort en omfattande utvecklingsresa från 1970-talet och framåt. Uppsatsen syftar till att belysa, med en rättsdogmatisk metod, vilka förändringar som gjorts och vilket perspektiv som ligger bakom dem. Regleringen har gått från att gemensam vårdnad enbart var aktuellt för gifta föräldrar, till en presumtion om att gemensam vårdnad The Swedish custody regulations can be found in the Children and Parents Code. These rules have gone through a huge development during the modern times. This essay aims to illustrate which changes has been made and the perspectives behind them. The regulation has gone from joint custody for married parents only, to a presumption that joint custody always shall apply and on to that the custody shal
Det är vedertaget i svensk rätt att avtal om framtida överlåtelse av fast egen- dom, såsom optionsavtal, är ogiltiga. En option är en rätt, men inte skyldighet, att i framtiden köpa eller sälja viss egendom. Även om det inte framgår explicit i lagtext eller förarbeten föreligger alltså i praktiken ett förbud mot option till fast egendom. Uppsatsens syfte är att granska huruvida det föreligger skälAgreements concerning future real estate transactions, such as option agree- ments, are invalid in the Swedish legal system. An option constitutes a right, but not an obligation, to buy or sell certain property in the future. There is a prohibition against option agreements to real estate, although it does not appear explicitly in the text of a law or the legislative history. The purpose of this t
The purpose of this study was to investigate men's experiences of being subjected to domestic violence by their female partners, identify the consequences of this violence, and analyse barriers to seeking help or leaving the relationship. The goal is to understand the nature of the violence and its impact on the men involved. Two theories have been used to analyse the results: Goffman’s theory
This paper is designed to examine the validity of the CAPM model in the emerging markets. I took the Indian market to be the case in which we examine the applicability of this model and therefore I decided to perform the study on one of the biggest Indian markets; Bombay Stock Exchange. The SENSEX30 was chosen as the examined index and I performed the study on the 28 listed companies in the market
Background: Psychiatric disorders have been associated with venous thromboembolism (VTE). However, to our knowledge, no nationwide study has examined the familial association between VTE and psychiatric disorders. Objectives: We took a pedigree-based approach and examined the risk of psychiatric disorders in offspring from extended pedigrees according to the densities of VTE in pedigrees. Methods:
UNLABELLED: Children with congenital and acquired heart disease have an increased risk of thromboembolic events. There is a paucity of evidence on the optimal approach to thromboprophylaxis for this population, and the introduction of direct oral anticoagulants in recent years has led to significant variation in clinical practice. The aim of the study was to describe current practice in thrombopro
Oxidative stress and alterations in redox signalling have been implicated in the pathophysiology of myocardial infarction (MI). NADPH oxidase (Nox) is an important source of reactive oxygen species (ROS) in the infarcted myocardium. Alarmin S100A8/A9 amplifies acute myocardial inflammation in MI and has been shown to be a promising therapeutic target to improve cardiac function post-MI. We aimed t
A meditation on gratitude, strangeness, and listening with careA deceptive cadence suggests resolution but withholds it, opening instead to uncertainty, fragility, and the unexpected. This philosophical-existential inquiry takes that musical figure as a metaphor for life itself—disrupted by illness, sustained by another’s gift, and reshaped by the presence of death. Music here becomes a vital comp
Trauma-induced hemorrhagic shock (HS) plays a decisive role in the development of immune, coagulation, and organ dysfunction often resulting in a poor clinical outcome. Imbalanced complement activation is intricately associated with the molecular danger response and organ damage after HS. Thus, inhibition of the central complement component C3 as turnstile of both inflammation and coagulation is h
OBJECTIVES: We assessed pharmacodynamic (PD) response for the reduced prasugrel 5-mg maintenance dose in very elderly (≥75y; VE) patients. BACKGROUND: In TRITON-TIMI 38, prasugrel 10-mg reduced ischemic events versus clopidogrel 75-mg, but increased bleeding in VE patients. METHODS: We examined PD and active-metabolite pharmacokinetics with prasugrel 5-mg and 10-mg and clopidogrel 75-mg in a three
In this paper we study an optimization problem relevant for wireless networks. In such networks links are subject to capacity disruptions caused by changing weather/channel condition that force to adapt the modulation and coding schemes to the observed condition. To cope with this issue in network optimization, we need to consider a so called link availability set A and a routing strategy that can
In order to characterize the post-Svecofennian tectonothermal evolution of the Fennoscandian Shield, 40Ar-39Ar biotite and some 40Ar-39Ar muscovite geochronological data are reported from a total of 30 surface outcrop and 1000 m long borehole samples at Forsmark, central Sweden. The thirteen surface samples were collected across three branches of a major WNW to NW trending system of deformation zo
