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Before, during, and after cardiac intervention, there is occasionally a need for circulatory support because of hemodynamic deterioration. For this purpose, a new minimally invasive cardiac assist device has been developed, and an early prototype has been studied in a bench test and in three pigs. The pump is a catheter system with a distal motor driven propeller (0-15,000 rpm) surrounded by a cag
The c. 4 km long artificial island Peberholm was constructed in 1995–1999 as a land-bridge between the tunnel and the bridge that was then built for the highway and railway across the strait of Öresund between Copenhagen (Denmark) and Malmö (Sweden). The island was mainly constructed from calcareous clay mixed with sand dug up from the bottom of the strait, but some stone and sand filling was tran
Human cystatin C variants in which the evolutionarily conserved Gly-11 residue has been replaced by residues with positively charged (Arg), negatively charged (Glu), bulky hydrophobic (Trp), or small (Ser or Ala) side-chains have been produced by site-directed mutagenesis and expression in Escherichia coli. The five variants were isolated and structurally verified. Their inhibitory properties were
Background: There are at least three broad conceptual models for the impact of the social environment on adult disease: the critical period, social mobility, and cumulative life course models. Several studies have shown an association between each of these models and mortality. However, few studies have investigated the importance of the different models within the same setting and none has been p
Cyclic and congenital neutropenia are caused by mutations in the human neutrophil elastase (HNE) gene (ELA2), leading to an immunodeficiency characterized by decreased or oscillating levels of neutrophils in the blood. The HNE mutations presumably cause loss of enzyme activity, consequently leading to compromised immune system function. To understand the structural basis for the disease, we implem
Background: Spontaneous bacterial peritonitis (SBP), which has been reported to be present in 10-30% of patients with cirrhotic ascites, may easily be overlooked. An important aim of our study was to determine whether there are any clinical signs which, in clinical practice, may predict or exclude SBP. Methods: We studied 133 patients with cirrhotic ascites from medical units at nine Swedish unive
Perseid and sporadic meteor hourly rates and magnitudes observed in 1953-1983 by a team of visual observers at the Onsala Space Observatory, Sweden, are analysed. A high-resolution study of the zenithal hourly rates of bright Perseid meteors /(m<=2.5) versus solar longitude has been made using a step length of /0.05° in solar longitude. The present study, which is based on 147 Perseid hourly rates
Object. Cerebral pressure autoregulation is an important neuroprotective mechanism that stabilizes cerebral blood flow when blood pressure (BP) changes In this study the authors examined the association between autoregulation and clinical factors. BR. intracranial pressure (ICP), brain tissue oxygen tension (PbtO(2)), and outcome after pediatric severe traumatic brain injury (TBI). In particular w
Decrease of the human brain temperature was induced by intranasal cooling. The main purpose of this study was to compare the two magnetic resonance methods for monitoring brain temperature changes during cooling: phase-difference and magnetic resonance spectroscopic imaging (MRSI) with high spatial resolution. Ten healthy volunteers were measured. Selective brain cooling was performed through nasa
The present study aimed to estimate possible differences in upper body muscular load between male and female house painters performing identical work tasks. Sex-related differences in muscular load may help explain why women, in general, have more musculoskeletal complaints than men. In a laboratory setting, 16 male and 16 female house painters performed nine standardised work tasks common to hous
Agricultural intensification has contributed substantially to the increase in food production, but has come at the expense of soil degradation and environmental problems. Management of soil based ecosystem services need to be considered in agricultural management since intensive management implies not only costs to the farmer but also to society. In this study we used data from four long-term (55
Flexicurity is a union of the English words flexibility and security. The union of the two words to one common term, hints that flexibility and security does not have to be each others counterparts in order to achieve good economical development and employment. Flexicurity, as it is found in Denmark, is described as a three part model composed of active labour market politics, generous financial c
In public safety oversight authorities are traditionally assumed responsible of safeguarding operation and promoting safety by defining prescriptions and observing that they are complied with. Regulated entities on their side are assumed responsibility for complying. While this compliance-based approach has contributed to current levels of safety, it is increasingly debated that it has limitatio
Syftet med detta arbete var att designa och bygga en externt driven proteshand. Handen ska helst ha en eller flera funktioner som inte finns hos andra protester. Den mänskliga handen är väldigt komplex, den innehåller över 30 muskler och minst 18 leder. Jämförelsevis har en komplex och rörlig kommersiell protes fem aktuatorer och elva leder, men endast en eller två kontrollsignaler. Allt som allt The purpose of the thesis was to design and build an externally powered prosthetic hand. The hand should preferably have one or more new functionalities not found in other prostheses. The human hand is very complex, it contains over 30 muscles and at least 18 joints. In comparison, a complex and dexterous commercial prostheses has five actuators and eleven joints, but only one or two control signa
Organizational strategists are working on their company’s ability to absorb and transfer knowledge between organizational units, their so-called absorptive capacity, to better react to environmental changes and, hence, strengthen their sustainable competitive advantage. In particular, the sharing of tacit know-how is considered to be difficult because it is contextual and experience-based, and, th
In 2018, images of migrant children held in cages and sleeping on concrete floors while being held in immigration detention in the United States shocked the world. Within the framework of the zero tolerance policy on immigration mandated by President Trump, thousands of families have been separated at the border. The trauma borne out of these separations was purposefully capitalized upon to serve
Denna rapport redogör för design och utveckling av ett medicintekniskt instrument för diagnos av kronisk obstruktiv lungsjukdom (KOL) eller emfysem. Arbetet utgår ifrån en ny diagnosmetod och ett instrument i form av en funktionell prototyp som används för att testa den nya diagnosmetoden. Med utgångspunkt i den funktionella prototypen har arbetet fokuserats kring att förstå vilka problem och utmThis thesis presents design and development of a medical device for diagnosis of emphysema or COPD by controlled lung deposition of nanoparticles. After purging the lungs with particle free air the subject inhales a controlled aerosol mixture and holds his breath for a determined period of time, before exhaling. The degree of lung disease is calculated by measuring and comparing the concentration
Introduction: Side-stream residue, oat okara, from the oat-milk production contains valuable nutrients but possesses a high risk of microbial spoilage. Valorisation of oat okara is therefore important to make sure that the oat beverage production stays sustainable. In this project, High-pressure processing (HPP), heat treatment and Lactobacillus fermentation have been evaluated for their microbial
Climate change is expected to alter soil nutrient availability and microbial community functionality. Inputs of labile carbon (C) from root exudates can stimulate the decomposition of soil organic matter (SOM) in a phenomenon known as “priming”; driven by microbial demand for limiting resources. Climate-driven changes in resource availability may therefore influence soil susceptibility to priming,
