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Background: With the implementation of a research project providing whole genome sequencing (WGS) to all pediatric cancer patients in Denmark (2016–2019), we sought to investigate healthcare professionals' views on WGS as it was actively being implemented in pediatric oncology. Methods: Semistructured interviews were carried out with pediatric oncologists, clinical geneticists, and research coordi
Background: Dietary advice remains the cornerstone of prevention and management of type 2 diabetes (T2D). However, understanding the efficacy of dietary interventions is confounded by the challenges inherent in assessing free living diet. Here we profiled dietary metabolites to investigate glycaemic deterioration and cardiometabolic risk in people at risk of or living with T2D. Methods: We analyse
BACKGROUND The efficacy and effectiveness of the quadrivalent human papillomavirus (HPV) vaccine in preventing high-grade cervical lesions have been shown. However, data to inform the relationship between quadrivalent HPV vaccination and the subsequent risk of invasive cervical cancer are lacking. METHODS We used nationwide Swedish demographic and health registers to follow an open population of 1
Aim: This study determined the use of standardised procedures for infant noninvasive blood pressure (NIBP) measurements in the Nordic countries and aimed to identify factors included in the standardisation and interpretation of NIBP measurements in infants. Methods: A cross-sectional electronic questionnaire survey was sent to 84 physicians in all 23 university hospitals in Sweden, Norway, Denmark
Sammanfattning Den svenska bostadshyresmarknaden präglas av en öppenhet för alla grupper i samhället. Syftet med den svenska bostadspolitiken är att skapa social, ekonomisk och etnisk mångfald i alla stadsdelar genom att kunna erbjuda prisvärt boende samt hyra oavsett inkomst. För att nå detta mål, införde Sverige samma hyressättningssystem för alla typer av bostäder, oavsett om de tillhandahölls Summary The Swedish housing market is characterized by being accessible to all groups in society and by the objective of achieving an overall social cohesion in its rental market. The purpose of this is to further integration and counter segregation by creating diverse neighborhoods accessible to all groups in society regardless of social status and for a reasonable price. To reach this goal, Swed
INTRODUCTION: Sympathomimetic (alpha-adrenergic) drugs are mainly used because of their vasoconstrictor properties, for nasal congestion, or as mydriatics. Although sympathomimetic drugs are used often, allergic reactions are rare, especially when the drugs are administered systemically. Cross-reactivity may exist among catecholamine derivatives, although reported data on this are contradictory. I
Background: The risk of sustaining a contra-lateral anterior cruciate ligament (C-ACL) injury after primary unilateral ACL injury is high. C-ACL injury often contributes to a further decline in function and quality of life, including failure to return to sport. There is, however, very limited knowledge about which risk factors that contribute to C-ACL injury. Objective: To systematically review in
Salinity gradient energy (SGE) can play an important role in the energy transition from fossil-based sources to renewable sources. Its potential is estimated to be around 625 TWh·a-1 corresponding to 3% of global electricity consumption [1]. SGE sources are most abundant in the estuaries where rivers meet seawater. However, it is also available in different forms such as brackish water, brine etc
Popular Abstract in Swedish I denna avhandling studeras ledningsförmågan hos nanometer-stora kvantprickar tillverkade i halvledarmaterial. Halvledare är material vars ledningsförmåga ligger någonstans mellan ledare (metaller) och isolatorer. I halvledare kan ledningsförmågan ändras med elektriska fält, vilket har möjliggjort utvecklandet av halvledartransistorn. Utvecklandet av halvledartransistorThis thesis focuses on electron transport in single and double quantum dots defined in low-dimensional, narrow-band-gap III-V semiconductor materials. Fabrication schemes are presented for defining single and double quantum dots in lateral InGaAs/InP heterostructures, either by a combination of etching and local gating or solely by local top gating. The quantum dots are here electrostatically conf
Sweden has experienced pronounced long-run fluctuations in fertility since the mid-twentieth century, alongside persistent within-year seasonality in births. While many fertility movements can be interpreted ex post in relation to economic conditions, cohort size, and institutional reforms, a central practical challenge is ex ante: when does an emerging decline become statistically detectable as t
Warnings of pathogens manufactured to target a specific ethnic group, so-called genetic bioweapons, have recently received considerable media attention. Genetic bioweapons figure prominently in reports on potential future risks emerging from combining genetic research, artificial intelligence and synthetic biology. They are also part of political narratives signaling imminent danger because of ong
Ethical issues in modern obstetrics commonly relate to a conflict between the rights and possibilities of the fetus versus those of the mother. After delivery, when the fetus by definition is a child, all legal rights are granted to this new individual. Whether any rights should be given or offered to the fetus is dependent on the prevailing situation. General rules are difficult to give due to th
Popular Abstract in Swedish Syftet med avhandlingen är att analysera den tekniska och organisatoriska ut¬vecklingen inom svensk banksektor under perioden 1975-2003 samt att se hur för¬ändringar i dessa två variabler påverkat produktivitetsutvecklingen. Utgångspunkten för analysen av den tekniska och organisatoriska förändringen är att det föreligger ett komplementärt förhållande mellan informationThe purpose of this thesis is to investigate the relation between technological and organizational change in the Swedish banking sector from 1975 to 2003. Besides analyzing the changes in these two variables the effects of the interaction on productivity changes in the sector are examined. The use of the concept of complementarity as a basis for analyzing the interaction between technological and
In recent years, interleukin-2 (IL-2) has been used as an immunomodulatory agent in the treatment of various malignant tumours. However, this treatment has been limited by serious side-effects, including toxic reactions in the lung. The effects of IL-2 treatment on inflammatory cell populations in the normal and irradiated rat lung were investigated in this study. IL-2 was continuously administere
Abstract We investigated the female-produced sex pheromone of the solitary bee Andrena nigroaenea and compared it with floral scent of the sexually deceptive orchid Ophrys sphegodes which is pollinated by Andrena nigroaenea males. We identified physiologically and behaviorally active compounds by gas chromatography with electroantennographic detection, gas chromatography-mass spectrometry, and beh
Prolonged inflammation and reactive oxygen species (ROS) generated around an implanted biosensor are the primary causes of the foreign body response, including encapsulation of biosensor membranes. We have previously demonstrated that TiO2 surfaces reduce ROS. Here we investigated the potential of using the anti-inflammatory properties of TiO2 in the design of biosensor membranes with improved lon
Lead (Pb) is one of the most important models for biomonitoring of exposure, with the blood Pb concentration as a predominant choice in practice and in epidemiology. In this article the alternatives for biomarkers to blood are reviewed. This overview focuses on a number of different qualities that are of importance in the evaluation of a biomarker's usefulness and performance. The qualities scruti
Objective: The proteoglycan decorin stabilizes collagen whereas biglycan and hyaluronan disrupt well-organized collagen. The aim was to compare hyaluronan and proteoglycans in human fetal membranes obtained before and after spontaneous labour at term. Study design: Prelabour samples of fetal membranes (N = 9) were obtained from elective caesarean sections and regionally sampled from over the cervi
Allergic rhinitis is an inflammatory nasal disorder in which a range of different cells participates. A variety of approaches has been used to monitor nasal inflammation objectively to investigate disease processes and to evaluate the effect of therapeutic intervention. These approaches include nasal lavage, nasal cytology, and nasal biopsy, together with the more recently established measurement
