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Certain retinal diseases that result in partial or complete visual loss due to the death of photoreceptor cells. These diseases can affect all ages, accounting for a significant fraction of blindness among younger adults in the developed world. Currently, no effective cure for these diseases exists. As they kill photoreceptors but leave the remaining retina and visual pathways comparatively intact
Background: The frequencies with which physicians make different medical end-of-life decisions (ELDs) may differ between countries, but comparison between countries has been difficult owing to the use of dissimilar research methods. Methods: A written questionnaire was sent to a random sample of physicians from 9 specialties in 6 European countries and Australia to investigate possible differences
Three-dimensional compaction simulations of geometries with circular and quadratic cross-sections are reported using dilatant viscoplastic material models representing a ductile steel powder. The simulations are compared with experiments using in situ measurements of the wall-tractions within the die. Two different porous viscoplastic material models have been used: the combined Fleck-Kuhn-MeMeeki
Retinitis pigmentosa is a blinding disease in which unknown mechanisms cause the degeneration of retinal photoreceptors. The retinal degeneration (rd1) mouse is a relevant model for this condition, since it carries a mutation also found in some forms of retinitis pigmentosa. To understand the degenerative process in the rd1 mouse, we must identify the survival and apoptosis-related signaling pathw
Cubic sillenite-type and monoclinic bismuth phosphates were synthesized via hydrothermal methods. Structure and morphology of cubic Bi13.1PO delta and monoclinic BiPO4 were characterized with a variety of analytical methods including powder X-ray diffraction, electron microscopy methods and surface area measurements. The humidity sensing properties of both bismuth phosphate types were investigated
Background Switching to a second tumour necrosis factor inhibitor (TNFi) after discontinuation of a first in rheumatoid arthritis (RA) is a common strategy. The reason for the switch from the first TNFi could potentially influence the response to therapy. Data on direct comparisons between TNFi after switching are limited. Methods The national Swedish register was used. RA patients who switched to
There is a widespread belief that EU underperforms in the commercialization of publicly funded research and that the appropriate policy response is to transfer the ownership of intellectual property rights to Universities. This paper assesses the validity of these twin beliefs. In addressing the first, we limit ourselves to Sweden which still retains its "Teacher's Exemption" model. In spite of co
In the robotic manipulation context, end-effector contact forces may be difficult to measure mainly due to the tool dynamic interferences Such as the inertial forces. In this paper, a whole methodology is proposed to estimate these forces. The new approach is based oil a sensor fusion technique that integrates the information of a wrist force sensor. of a 3D accelerometer placed at the robot tool
This study explores metabolic responses of germinating barley seeds upon the application of pulsed electric fields (PEE). Malting barley seeds were steeped in aerated water for 24 h and PEF-treated at varying voltages (0 (control), 110, 160, 240, 320, 400 and 480 V). The seeds were then allowed to finish germination in saturated air. It is shown that exposure of germinating barley to PEE affects r
We present a protocol for a facile orientation specific deposition of plate-like mesoporous SBA-15 silica particles onto a surface (mesopores oriented normal to surface). A drop of an aqueous dispersion of particles is placed on the surface and water vaporizes under controlled relative humidity. Three requirements are essential for uniform coverage: particle dispersion should not contain aggregate
High-spin states in I-122 have been investigated using the Cd-116(B-11,5n)I-122 reaction at a beam energy of 65 MeV and gamma-ray coincidence events were recorded with the INGA spectrometer. The level scheme of I-122 has been extended up to spin I = 30. Experimental features, such as band-crossing frequencies, aligned angular momenta, signature splitting, and B(M1)/B(E2) ratios have been used for
This paper takes issue with a recent proposal due to Shogenji (Synthese 184:29-48, 2012). In his paper, Shogenji introduces J, a normatively motivated formal measure of justification (and of confirmation), and then proceeds to recruit it descriptively in an explanation of the conjunction fallacy. We argue that this explanation is undermined by the fact that it cannot be extended in any natural way
This paper explores how regulatory relationships in the global audit arena are being affected by the current financial crisis. Key policy initiatives and debates are analyzed, along with Institutional interactions, in particular between the International Federation of Accountants (IFAC), international regulators and the large audit firms. The events are placed in the context of the new internation
This study explores the roles of genetic variation and phenotypic plasticity for explaining patterns of local wing colour variation in the common blue butterfly, Polyommatus icarus. Polyommatus icarus is one of the most widespread species of butterflies in Europe. Across its range, the female varies a lot in its dorsal colour, from all brown to almost totally blue. It has been suggested that, in S
Syftet med studien var att undersöka hur personlighet med utgångspunkt från Femfaktorsmodellen förhåller sig till hur en hypotetisk idealpartner uppfattas utifrån Attraction Similarity Theory och Complementary Needs Theory. I tillägg till detta gjordes en jämförelse mellan olika sexuella läggningar för att undersöka eventuella skillnader. Metoden som valdes var en kvantitativ survey-studie som förThe purpose of the study was to investigate how personality based on the The Big Five Model relates to how a hypothetical ideal partner is perceived based on Attraction Similarity Theory and Complementary Needs Theory. In addition to this, a comparison was made between different sexual orientations to investigate possible differences. The method chosen was a quantitative survey study that was dist
In recent years, public as well as private measures taken in order to protect the environment have proved to affect competition. As consumers have become more and more alert to the environmental effects of the manufacture, use and ultimate disposal of goods, undertakings have taken measures improving the environmental protection not only due to legislation imposing stricter standards on products a
BACKGROUND: Inversions involving intron 22 (Inv22) of F8 are detected in approximately 45% of all severe hemophilia A patients. Diagnosis is complicated by the large size of the ~9.5 kb int22h repeated sequence which generates the inversions. Methods such as long-range PCR and inverse-shifting PCR are currently used diagnostically, but suffer from low PCR efficiencies and are difficult to standard
We studied mutation kinetics in ten relapsing and four non-relapsing patients with acute myeloid leukemia by whole exome sequencing at diagnosis to identify leukemia-specific mutations and monitored selected mutations at multiple time-points using IBSAFE droplet digital PCR. Five to nine selected mutations could identify and track leukemic clones prior to clinical relapse in 10/10 patients at the
Qinghai-Tibet Plateau grasslands are unique geographical regions and store substantial soil organic matter (SOM) in the soil surface, which make them very sensitive to global climate change. Here, we focused on three main grassland types (alpine meadow, steppe, and desert) and conducted a soil incubation experiment at five different temperatures (5, 10, 15, 20, and 25°C) to investigate SOM decompo
In the present work we have performed classical molecular dynamics modelling to investigate the effects of different types of force-fields on the stress-strain and yielding behaviours in semi-crystalline lamellar stacked linear polyethylene. To this end, specifically the all-atomic optimized potential for liquid simulations (OPLS-AA) and the coarse-grained united-atom (UA) force-fields are used to
