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Statistical emulation allows combining advantageous features of statistical and process-based crop models for understanding the effects of future climate changes on crop yields. We describe here the development of emulators for nine process-based crop models and five crops using output from the Global Gridded Model Intercomparison Project (GGCMI) Phase 2. The GGCMI Phase 2 experiment is designed w
Atomic diusion and mixing processes in stellar interiors influence the structure and the surface composition of stars. Some of these processes cannot yet be modelled from the first principles, and they require calibrations. This limits their applicability in stellar models used for studies of stellar populations and Galactic evolution. Aims. Our main goal is to put constraints on the stellar struc
Background: Contamination of drinking water by hazardous chemicals can be associated with human health risks. Recent studies using effect-based in vitro methods have demonstrated that a large part of the observed toxic effects are caused by unknown chemicals. In this study, we have used a panel of effect-based methods to study the presence of chemical contaminants in a unique material; glass-bottl
Background: Treatment adaptation based on tumour biomarker response during radiotherapy of prostate cancer, could be used for both escalation and de-escalation of radiation doses and volumes. To execute an adaptation involving extension of treatment volumes during radiation can however be restricted by the doses already delivered. The aim of this work was to develop a treatment planning method tha
Purpose: To assess score agreement between the Atroshi-Lyrén 6-item symptoms scale and the Boston 11-item symptom severity scale and compare their responsiveness in patients with carpal tunnel syndrome before and after carpal tunnel release surgery. Methods: This prospective cohort study included 3 cohorts that completed the A-L and Boston scales (conventional score 1–5) on the same occasion: a pr
Aims and objectives: To describe ways in which children's best interests were observed to be expressed in paediatric settings during their hospital visit.Background: The best interests of the child are embodied in national and international legal systems, although the definition remains problematic. The child's limited autonomy mandates duty bearers to have both a child perspective and the child's
Assessing the optimal placement and design of a large‐scale high temperature energy storage system in crystalline bedrock is a challenging task. This study applies and evaluates various methods and strategies for pre‐site investigation for a potential high temperature borehole thermal energy storage (HT‐BTES) system at Linköping in Sweden. The storage is required to shift approximately 70 GWh of e
Insect odorant receptor (OR) genes are routinely expressed in Human Embryonic Kidney (HEK) 293 cells for functional characterization (“de-orphanization”) using transient or stable expression. However, progress in this research field has been hampered because some insect ORs are not functional in this system, which may be due to insufficient protein levels. We investigated whether codon optimizatio
In a population-based case-control study in Sweden on multiple myeloma, the occurrence of different diseases in relatives, particularly hematologic malignancies and different types of cancer, was investigated. Through a questionnaire mailed to all living subjects, i.e. cases and controls, and to the next-of-kin for deceased subjects, information was obtained on malignant and certain other diseases
Fatty acids (FA) have crucial functions in animals, affecting e.g. inflammatory responses, thermoregulation, and cell membrane fluidity. Diet and ambient temperature affect animals’ FA composition, which, in turn, may influence these physiological processes. Great tit (Parus major) −common in both urban and rural habitats− are mainly granivorous during winter and insectivorous during summer. These
We investigated the distribution of neuropathologically defined dementia subtypes among individuals with dementia disorder. The neuropathological reports were studied on all patients (n=524; 55.3% females; median age 80, range 39-102 years) with clinically diagnosed dementia disorder who underwent complete autopsy including neuropathological examination within the Department of Pathology at the Un
Background: Risk gene variants for celiac disease, identified in genome-wide linkage and association studies, might influence molecular pathways important for disease development. The aim was to examine expression levels of potential risk genes close to these variants in the small intestine and peripheral blood and also to test if the non-coding variants affect nearby gene expression levels in chi
To gain entry into target cells, HIV-1 binds to CD4 via the viral glycoprotein gp120. This interac-tion initiates a series of events including binding of a coreceptor, CCR5 and/or CXCR4, and ulti-mately leads to gp41-mediated fusion of the viral and cell membranes. CCR5-restricted (R5) vi-ruses predominate in early, asymptomatic stages of the infection. Emergence of viruses able to use CXCR4 inste
Insulin sensitivity declines in overweight and obese individuals and, under normal conditions, insulin secretion adaptively increases which in healthy non-diabetic subjects maintains normal glycemia. This adaptation is best described by the disposition index derived from modeling of insulin and glucose data from an intravenous glucose tolerance testing (IVGTT). One caveat of the IVGTT is that basi
BACKGROUND: Hypothermia may be accidental or therapeutic. Therapeutic hypothermia is increasingly used as treatment for various conditions, e.g., neuroprotection after cardiac arrest. Hypothermia leads to an impairment of the coagulation system, but the degree of impairment has been difficult to determine. Most studies have been performed on plasma instead of whole blood. We therefore evaluated wh
Aims State-of-the-art methodology was used to screen and profile the placenta, gene and protein expression, for changes related to preeclampsia (PE) and cases with increased resistance in the uterine arteries. Women with increased resistance in the uterine arteries have increased risk of developing PE. Since not all of them develop PE, this group, identified by Doppler ultrasound, was included to
Våld i nära relationer är ett allvarligt och alarmerande samhällsproblem. I skuggan av våldet lever hundratusentals barn som tvingas bevittna våldet på nära håll. Uppsatsen syftar till att redogöra för samt analysera det straffrättsliga skydd för barn som bevittnar våld genom användning av en rättsanalytisk metod. Materialet som använts för uppsatsens framställning grundas på de allmänna rättskällDomestic violence is a serious and alarming social problem. Hundreds of thousands of children live in the shadow of domestic violence, forced to witness the brutality up close. The aim of this thesis is to describe and analyze the criminal justice protection available to these children by using a forensic method. The material used for this essay is based on the general sources of law together with
Uppsatsen behandlar de rättsliga regleringar som utgör gällande rätt vid häktning av unga mellan 15-17 år. Syftet för uppsatsen är att utreda om denna reglering är rättssäkert utifrån principen om förutsägbarhet. För att göra detta redovisas regleringen om frihetsberövande generellt, för att vidare begränsas till frihetsberövande genom häktning och sedermera behandla regleringen gällande unga mellThe thesis deals with the legal regulations that constitute the current law on the detention of young people aged 15-17. The purpose for the essay is to investigate whether this regulation is legally secure based on the principle of predictability. In order to do this, the regulation on deprivation of liberty is described in general, then limited to deprivation of liberty by means of detention and
Syftet med förevarande uppsats är att belysa umgängessabotage och dess eventuella konsekvenser. Närmare bestämt avses att undersöka hur ett eventuellt umgängessabotage påverkar tingsrätten i sin bedömning när den har att ta ställning till vad som innebär barnets bästa (se föräldrabalken 6 kap. 2 a §). Umgängesrätten har utvecklats från att vara en rättighet avsedd för den förälder som utan grund hThe purpose of this essay is to highlight the consequences of the situation where one parent without acceptable cause refuses the other parent’s right of access with their child, hereinafter called ‘access sabotage’. The purpose is more specifically to investigate how the situation of access sabotage is affecting the district court in its assessment when it has to consider what outcome will be in
