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Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish the heritability of glycaemic response to metformin using the genome-wide complex trait analysis (GCTA) method.
Environmental relative humidity (RH) and temperature (T) are known to be promoters of physicochemical changes in pharmaceutical grade lactose, either in controlled (supervised conditioning), or uncontrolled (during transit and repository storage) scenarios. Comprehensive knowledge of this excipient's material characteristics prior to its use in formulation development is therefore a fundamental re
Purpose: At the inception of the Journal of Humanitarian Logistics and Supply Chain Management (JHLSCM), logistics coordination was identified as important, both in practice and research, but few studies on the topic had been published. Ten years later, many, if not most, papers in the journal mention the topic. So the picture has changed, but to what extent? This paper discusses how coordination
The length of the growing season for deciduous trees in temperate and boreal forests is determined by the timing of bud burst and autumn senescence. It is generally assumed that a warmer climate leads to a longer growing season due to earlier bud burst and delayed autumn senescence and thereby increased gross primary production (GPP) of forests. In this study, we analysed past (1873–1951) and curr
Objective: No dedicated studies have been performed on the optimal management of patients with an acute stroke related to carotid intervention nor is there a solid recommendation given in the European Society for Vascular Surgery guideline. By implementation of an international expert Delphi panel, this study aimed to obtain expert consensus on the optimal management of in hospital stroke occurrin
The goal of this study is to determine whether peripheral blood volume fluctuations triggered by ventricular premature beats (VPBs) are significantly related to hypotensive symptoms during dialysis treatment. Patients treated with hemodialysis often suffer from cardiovascular disorders and uremic neuropathy, increasing the propensity to homeostatic imbalance that, in turn, may result in intradialy
Background: Oral polio vaccine (OPV) is recommended to be given at birth together with BCG vaccine. While we were conducting two trials including low-birth-weight (LBW) and normal-birth-weight (NBW) infants in Guinea-Bissau, OPV was not available during some periods and therefore some infants did not receive OPV at birth, but only BCG. We investigated the effect of OPV given simultaneously with BC
Objectives. To investigate survival, treatment escalation, effects of first-line single- and first-line combination therapy and prognostic markers in idiopathic- (IPAH), hereditary- (HPAH) and connective tissue disease-associated (CTD-PAH) pulmonary arterial hypertension (PAH). Design. Retrospective analysis of medical journals from PAH patients at Skane University Hospital 2000-2011. Results. 1-,
The roles that adventitious roots play in flooding tolerance have been well-studied in willows, while which of the maximum height of adventitious roots and the abundance of adventitious roots in willows is more important for their flooding tolerance is not well known. In this study, we analyzed the effects of adventitious roots on the flooding tolerance of Salix cavaleriei by comparing the maximum
Due to its hemizygous inheritance and role in sex determination, the X-chromosome is expected to play an important role in the evolution of sexual dimorphism and to be enriched for sexually antagonistic genetic variation. By forcing the X-chromosome to only be expressed in males over >40 generations, we changed the selection pressures on the X to become similar to those experienced by the Y. This
Vegetation is an important component of the terrestrial ecosystem that plays an essential role in the exchange of water and energy in climate and biogeochemical cycles. This study investigated the spatiotemporal variation of normalized difference vegetation index (NDVI) in northern China using the GIMMS-MODIS NDVI during 1982–2018. We explored the dominant drivers of NDVI change using regression a
Helicobacter pylori is a major factor for the development of gastric cancer. The aim of this study was to define serum antibody patterns associated with H. pylori infection in patients with gastric cancer using a Western blot technique. Serum samples collected from 115 patients with gastric cancer and 110 age- and gender-matched patients without gastrointestinal diseases were tested for IgG antibo
The food intake rate of foragers may be reduced as a result of interference, which may be asymmetric among individuals and occur as a result of intimidation, direct aggression or filtering. It is important to distinguish among these types of interference, because each can have different consequences for individuals, foraging groups and populations. We demonstrate the application of the functional
We analyze the microscopic few-body properties of dipolar particles confined in two parallel quasi-one-dimensional harmonic traps. In particular, we show that an adiabatic rotation of the dipole orientation about the trap axes can drive an initially nonlocalized few-fermion state into a localized state with strong intertrap pairing. With an instant, nonadiabatic rotation, however, localization is
The power of visual imagery is well known, enshrined in such familiar sayings as "seeing is believing" and "a picture is worth a thousand words." Iconic photos stir our emotions and transform our perspectives about life and the world in which we live. On September 2, 2015, photographs of a young Syrian child, Aylan Kurdi, lying face-down on a Turkish beach, filled the front pages of newspapers wor
