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Background: 4-1BB (CD137) is a co-stimulatory receptor highly expressed on tumor reactive effector T cells and NK cells, which upon stimulation prolongs persistence of tumor reactive effector T and NK cells within the tumor and induces long-lived memory T cells. 4-1BB agonistic antibodies have been shown to induce strong anti-tumor effects that synergize with immune checkpoint inhibitors. The firs
Background: Nigeria is a major contributor to the global malaria burden. The genetic diversity of malaria parasite populations as well as antibody responses of individuals in affected areas against antigens of the parasite can reveal the transmission intensity, a key information required to control the disease. This work was carried out to determine the allelic frequency of highly polymorphic Plas
Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First,
Antimicrobial peptides (AMPs) are evolutionarily ancient molecules. They are essential innate immune response molecules that protect organisms from invading pathogens. Tissue factor pathway inhibitors (TFPI-1 and TFPI-2) C-terminal derived peptides exert host defense mechanisms against microbes. Studies showed that in human plasma, C-terminal TFPI-1 and -2 derived peptides mediate bacterial killin
Small synthetic ligands for protein purification have become increasingly interesting with the growing need for cheap chromatographic materials for protein purification and especially for the purification of monoclonal antibodies (mAbs). Today, Protein A-based chromatographic resins are the most commonly used capture step in mAb down stream processing; however, the use of Protein A chromatography
Estimating perfusion information from diffusion MRI (dMRI) demands an accurate model of flow and geometry in the microvascular network. While models of flow in the diffusive and ballistic regime are well explored, modelling in the intermediate regime constitutes a significant challenge. Approaches are often complex, and simpler models are necessary to gain insight. The aim of this thesis is to est
Thailand is facing with various extreme climate events from flood to drought. As a result of climate change, these events tend to increase in frequency and intensity. The existing water infrastructures and management is showing sign of fragility and incapable of dealing with these challenges. To increase adaptive capacity and tackle current water resource challenges, water management agencies in T
Arbetsrehabilitering Efterfrågan på evidensbaserade insatser har ökat markant i Sverige och Individual Placement and Support (IPS) är en av de högst prioriterade psykosociala insatserna i Socialstyrelsens nationella riktlinjer. Utbildningen har gått regelbundet sedan 2012 och fokuserar nu även på Supported Education. Särskild tonvikt i utbildningen kommer att läggas vid implementeringen av IPS i b
https://www.medicin.lu.se/sites/medicin.lu.se/files/uppdragsutbildning_ips_ht_2020.pdf - 2026-10-09
Microsoft Word - Akustisk komfort i musikövningsrum.doc Master’s Dissertation Engineering Acoustics FREDRIC JANSON Report TV BA -5035 FRED RIC JA N SSO N A K U STISK K O M FO R T I M U SIK Ö V N IN G SR U M AKUSTISK KOMFORT I MUSIKÖVNINGSRUM TA_5035HO.indd 1 2009-03-31 14:34:55 Detta är en tom sida! Copyright © 2006 by Engineering Acoustics, LTH, Sweden. Printed by KFS I Lund AB, Lund, Sweden, Mar
https://www.akustik.lth.se/fileadmin/tekniskakustik/publications/tvba5000/webTVBA5035.pdf - 2026-09-21
CRISPRideas TEMA 2019-2020 Utvecklingen av nya genredigeringstekniker som CRISPR-Cas9 har skapat en revolution inom biologisk och medicinsk forskning. De innebär möjligheter att göra precisa och riktade förändringar i arvsmassan på alla slags organismer, från mikroorganismer till människor. Inom växtförädlingen finns förhoppningar att kunna utveckla nya grödor som är bättre anpassade till ett fram
https://www.pi.lu.se/sites/pi.lu.se/files/2021-01/CRISPR%20SVE.pdf - 2026-10-09
Capitulation is wisdom - not defeat! The aim of this study has been an attempt to clarify how parents of children with neuropsychiatric disabilities such as autism, Down syndrome and intellectual disability manage to cope in their everyday life despite the high levels of stress and long term strain it involves being a parent and a caretaker of such a child. We focused our study on the family as a
Climate change poses an immediate challenge to every actor in society. In this rapidly changing context, organizations are faced with a need to make structural changes to their business strategy and operations as current business models are challenged. Communication is a vital aspect and determinant of organizational change. The purpose of this study has been to examine how an organization communi
