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Neuroblastoma and ganglioneuroma are neuroblastic tumors originating from the developing sympathetic peripheral nervous system. Ganglioneuromas are usually benign, while neuroblastomas have a variable prognosis and include very aggressive tumors. Examples exist of neuroblastomas regressing to ganglioneuromas and ganglioneuromas progressing to neuroblastomas. Little is known of the molecular differ
Helicobacter pylori infection is associated with gastritis, ulcerations, and gastric adenocarcinoma. H. pylori secretes the vacuolating cytotoxin (VacA), a major pathogenicity factor. VacA has immunosuppressive effects, inhibiting interleukin-2 (IL-2) secretion by interference with the T cell receptor/IL-2 signaling pathway at the level of calcineurin, the Ca2+-calmodulin-dependent phosphatase. He
The actinomycete Corynebacterium glutamicum grows as rod-shaped cells by zonal peptidoglycan synthesis at the cell poles. In this bacterium, experimental depletion of the polar DivIVACG protein resulted in the inhibition of polar growth; consequently, these cells exhibited a coccoid morphology. This result demonstrated that DivIVA is required for cell elongation and the acquisition of a rod shape.
The kinin B1 receptor (B1R) is a G protein-coupled receptor with pro-inflammatory activity that is latent in healthy tissues but induced by tissue insult. Here, we investigated if B1R homo-oligomerization is a possible mechanism regulating the presentation of this receptor at the level of maturation and trafficking to the cell surface. To this end, we used HEK293 cells stably expressing N-terminal
Objective: To examine whether smoking is a risk factor for rheumatoid nodules in early rheumatoid arthritis, and if so to determine the quantitative effect of smoking. Methods: From a cohort (n = 1589) in a structured programme for follow up of newly diagnosed cases of rheumatoid arthritis ( symptoms of swollen joints ( 12 months), 112 individuals with rheumatoid nodules at inclusion were identifi
BCS1L is a chaperone necessary for the incorporation of Rieske Fes and Qcr10p into complex III (CIII) of the respiratory chain. Mutations in the BCS1L gene cause early fetal growth restriction and a lethal neonatal disease in humans, however, the pathogenesis remains unclear. Here, we analysed the expression of BCS1L during mouse embryonic development and compared its expression with that of the m
Our previous studies have indicated that endogenous nitric oxide serves as a physiologically important inhibitor of vascular tone during acute haemorrhage. This vasodilator action attenuates the concomitant reflex adrenergic constriction and thereby prevents critical reduction of tissue blood flow. The present study aimed to evaluate the overall importance of this nitric oxide regulation for survi
The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms of muscular dystrophy. Dystroglycan is a receptor for multiple extracellular matrix (ECM) molecules such as Laminin, agrin and perlecan, and plays a role in linking the ECM to the actin cytoskeleton; however, how these interactions are r
The cytosolic Ca2+-binding S100A9 and S100A8 proteins form heterodimers that are primarily expressed in human neutrophils and monocytes. We have recently shown that S100A9 binds to TLR4 in vitro and induces TLR4-dependent NF-κB activation and a pro-inflammatory cytokine response in monocytes. In the present report we have further investigated the S100A9-mediated stimulation of TLR4 in monocytes. U
Distraction is an emotion regulation strategy that has an ambiguous status within cognitive-behavior therapy. According to some treatment protocols it is counterproductive, whereas according to other protocols it is seen as a quite useful strategy. The main purpose of the present study was to test the hypothesis that distraction is adaptive when combined with active acceptance, but maladaptive whe
Summary The bacterial endospore is a dormant and heat-resistant form of life. StoA (SpoIVH) in Bacillus subtilis is a membrane-bound thioredoxin-like protein involved in endospore cortex synthesis. It is proposed to reduce disulfide bonds in hitherto unknown proteins in the inter-membrane compartment of developing forespores. Starting with a bioinformatic analysis combined with mutant studies we i
As Trump's pursuit of Greenland escalated throughout 2025 and into 2026, the Danish government has faced mounting pressure to justify its authority over the territory, both on the international stage and within its domestic sphere. This thesis examines how Danish officials discursively construct and legitimize that authority in response to repeated threats from Trump. Drawing on Fairclough'
Trust is widely recognised as an important determinant of lending relationships, yet existing finance literature typically treats trust as a single construct and rarely examines how different trust dimensions operate across financial contracts with distinct risk structures. Our research addresses this gap by distinguishing between competence-based trust (perceived managerial capability) and value-
Commercialization has been recognized as one of the most difficult phases of the innovation process. Failure rates are high, even for products with the potential to address real needs and deliver real customer value. This master's thesis explores commercialization in an even more challenging business context than the typical case. First, the innovating company is an early startup with limited
The purpose of this report is to map how HTA, Health Technology Assessment, is being used for MDD products for inpatient care in Sweden. Swedish Medtech, a professional association for medical technology companies, has a need to carry out a survey about the use of HTA in Sweden for their future work. They have a project which goal is to inform policy makers about the value of innovative medical pr
This population-based register study examined if factors during the fetal and neonatal period influence the risk for the child to develop bronchial asthma (asthma). From the Swedish Hospital Discharge Register we identified children, born between 1987 and 1999, who had been hospitalized for asthma up to 2001. Thus, the outcome measure contains only hospitalized cases, not all children with asthma.
