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GLPG1972/S201086 is a disintegrin and metalloproteinase with thrombospondin motif-5 (ADAMTS-5) inhibitor in development as an osteoarthritis disease-modifying therapy. We report the safety, tolerability, pharmacokinetics, and pharmacodynamics (turnover of plasma/serum ARGS-aggrecan neoepitope fragments [ARGS]) of GLPG1972 in 3 randomized, double-blind, placebo-controlled phase 1 trials. Study A, a
Despite high country-level gender equality, intimate partner violence against women (IPVAW) is common in Sweden. In discussion about this apparent paradox, the complexity of gender in/equality has been highlighted. Drawing on the domains considered in the EIGE gender equality index (work, money, knowledge, time, power, and health), and based on thematic analysis of semi-structured interviews with
Objectives Structural valve deterioration is an inherent limitation of bioprosthetic valves; however, the time it takes to develop varies depending on the valve model. The Sorin Soprano aortic bioprosthetic valve (Sorin Group/LivaNova, Milan, Italy) lacks reported long-term results. This study aims to establish the long-term durability of this bioprosthetic valve in a nationwide cohort. Methods Al
Purpose: The study aimed to describe patients’ experiences of physical, psychological, social, and existential symptoms and challenges during the first year after allogeneic haematopoietic cell transplantation (allo-HCT). Methods: Quantitative and qualitative data were collected and analysed with descriptive methods as part of a large retrospective cross-sectional online survey of patients who und
Conventional Quality of Service(QoS) measurements are incapable to meet the demand for analysing communication performance on timeliness of information in Industrial Control Networks with many connected subsystems. The Age of Information (AoI) and the Age of Actuation (AoA) give a promise to be a solution. Many recent research articles cover theoretical aspects and analyse performance characterist
Purpose: To explore healthcare professionals' (HPs’) experiences of work-related challenges among people with inflammatory arthritis (IA). Methods: A qualitative, interview study using a hermeneutic approach was planned. HPs with different professional backgrounds working with people with rheumatic diseases were recruited. An interview guide was developed according to relevant literature. The anal
Background: The increased prevalence of atopic diseases may be due to lifestyle changes affecting our exposure to microbes. We investigated the association between infections, fever, and atopic diseases in a large international birth cohort setting. Methods: 3842 children at genetic risk for type 1 diabetes were followed prospectively for the first 10 years for the occurrence of infections and ato
Background: Pain in children is undertreated. An assessment scale co-designed with children, parents, and health care professionals could lead to more effective pain assessments and treatment strategies aimed at reducing pain and pain-related symptoms. There are analogue scales validated for self-report of pain in children, but today, children regularly use digital technology, which healthcare sho
Background This prospective cohort study aimed to assess whether postoperative radiotherapy could safely be omitted in women aged 65 years and older with low-risk, estrogen receptor-positive T1N0 breast cancer treated with breast-conserving surgery and adjuvant endocrine therapy. Methods Eligible patients were women aged 65 years and older with unifocal, nonlobular, grade 1 or 2, estrogen receptor
Background: Acute aortic syndrome (AAS) is a life-threatening condition reported as often misdiagnosed. Advancements in CT availability and diagnostic algorithms, including high-sensitivity troponin and D-dimer for acute coronary syndrome (ACS) and pulmonary embolism (PE), may reduce AAS misdiagnosis, but the impact remains unclear. This study evaluated the incidence, characteristics, and clinical
Experimental and numerical studies were performed to understand the flame characteristics and cooling effect of jet-cooled wall flameholders in a simplified augmented combustor. The time-averaged flame structure and wall temperature were investigated employing an instantaneous flame capturing system with image processing technology and a wall temperature measurement system, respectively. Flow and
BACKGROUND: Thirty-eight years of pediatric heart transplantation (pHTx) within the Scandiatransplant organization were analyzed to describe volume trends, regional prevalence, underlying etiologies and outcomes following listing and pHTx.METHODS: Children <18 years listed for pHTx from January 1st 1986 to December 31st 2023 were identified in the Scandiatransplant registry. The cohort was split i
Patients with systemic lupus erythematosus (SLE) face an approximately 30 % risk of thrombosis post-diagnosis. However, there remains significant knowledge gaps regarding causative mechanisms, and there is a lack of specific antithrombotic guidelines. This systematic review aims to examine the existing literature regarding the mechanisms contributing to thrombosis risk in SLE, focusing on five pre
This chapter takes an interest in the construction of gendered knowledge in the digital space. Through an analysis of the digital activism of the epistemic agent Nadia Murad, survivor of the genocide against the Yazidi, the chapter investigates how she departs from her personal, embodied experience of ISIS violence to advocate for justice, recognition and reparation. Through the methodological app
During the last couple of decades in Europe we have witnessed a proliferation of artistic practices -what we might call the “political turn” - that sought to experiment with models of democracy and participation, as well as forms of intervention in socio-political realities. At the same time, in Southern Europe and beyond a series of social collective practices emerged in the face of an ongoing ec
The aim of this thesis is to study how Muslim converts with a Swedish background experience and negotiate their subject positions as new Muslims in Sweden, mainly in relation to the reactions on their conversion from family, friends and others. Apart from this main question, I also treat questions such as: How can the reactions from others be understood in relation to certain ideas about “Swedishe
This study shows that the framework used to construct the successful Euro Area Leading Indicator (ALI), developed by de Bondt and Hahn on behalf of the European Central Bank, can successfully be applied to the Swedish business cycle. The ALI type indicator constructed in this study is a weighted index of nine macroeconomic series and accurately predicts the Swedish business cycle by three months (
The thesis evaluates the Swedish EITC and its effect on the employment rate. The Swedish EITC was introduced in 2007 to encourage more people to enter the labor market. This will be evaluated with a difference-in-difference method. The fact that the tax rate in the municipality is an important part of the formula for the EITC will be used to form groups depending of the size of the tax rate. A mun
This research draws attention to the way undocumented Albanian immigrant women experience their everyday life in Greece. Which are the structural factors experienced by Albanian undocumented immigrant women that defines their everyday life in Greece and what strategies are used by these women in order to resist these macro-structural factors. Qualitative interviews were held with 11 undocumented A
Citizenship is subject of much debate in democratic societies. This can be explained by the fact that the school systems contribute to the reproduction of the political system through the education of good, democratic citizens. Sweden has gone through major ideological change in the past 30 years, the social democratic welfare state has been influenced by neo-liberal ideas regarding government. Th
