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RATIONALE AND OBJECTIVES: We wanted to improve determination of the glomerular filtration rate (GFR) with plasma clearance techniques because the alternative-renal clearance techniques-may involve inaccurate urine sampling or risk of urinary tract infection when bladder catheterization becomes necessary. Therefore, we compared the renal and plasma clearances of iohexol and chromium-51-ethylenediam
SUMMARY: When Efexor(R) (venlafaxine) became available in Sweden, a therapeutic drug monitoring (TDM) service was developed in the authors' laboratory. This analytical service was available to all physicians in the country. From March 1996, to November 1997, 797 serum concentration analyses of venlafaxine (VEN) and its main metabolites, O-desmethylvenlafaxine (ODV), N-desmethylvenlafaxine (NDV), a
Popular Abstract in Swedish Aktie- och fondsparandet bland allmänheten har ökat dramatiskt i Sverige under 1990-talet, och allt fler företag har valt börsintroducering som finansieringsform. På så sätt har frågor som rör värdepappersmarknaden fått en ökad och mer allmän relevans, inte minst när det gäller regleringen av vad som är tillåtet och otillåtet att göra på marknaden. Både från statligt håIn this dissertation the Swedish Financial Supervisory Authority's (FSA) investigation of suspected insider trading offences is examined and analysed. The aim of the study is to describe FSA's investigative activity in insider cases during the 1990?s, a period of both increased activity on the Swedish stock market as well as changed regulation. The study places the investigation of insider offence
Large segments of the rural Timorese population survive on subsistence farming characterized by simple production methods and low output. Broad-based improvements in Timorese living standards require increased agricultural output. This article discusses what determines agricultural development in Timor-Leste and how such development can be achieved. The main causes of low agricultural output is fo
In a north European context, identifying invasive species is far from trivial because the vegetation has been influenced by human activities for thousands of years. New species have immigrated continuously since the end of the last glaciation, both spontaneously and through direct or indirect help by man. Still, newly immigrated species may be problematic in a nature conservation context and may h
Current forest Free Air CO2 Enrichment (FACE) experiments are reaching completion. Therefore, it is time to define the scientific goals and priorities of future experimental facilities. In this opinion article, we discuss the following three overarching issues (i) What are the most urgent scientific questions and how can they be addressed? (ii) What forest ecosystems should be investigated? (iii)
When developing products, engineering designers often face the problem that their candidate for a technical solution, ranging from a concept to a detailed design, needs to be analyzed by a design analyst before it is approved or rejected and the engineering designer can continue his/her activities within the product development process. If engineering designers have to send every solution candidat
Governance is hybrid to the extent that it involves several types of stakeholders, jurisdictional domains, and organisational forms. This paper analyses governance of household solid waste management in Sweden from a hybridity perspective, with the City of Helsingborg as example. The empirical material on which the paper is based consists of interviews with politicians, civil servants and manageme
The purpose of the study was to (1) observe the frequency of giving way to pedestrians at the zebra crossing, (2) reveal speed adaptation problems, (3) examine if the time difference between the arrival of the pedestrian and the car have any influence on the speed of the approaching car, (4) identify so-called “ideal” situations (in which the car brakes on the driver’s own initiative in order to g
Popular Abstract in Swedish Att få en övergripande förståelse för hur mänskliga celler påverkas av metallbaserade läkemedel är viktigt, eftersom de har visat sig vara väldigt effektiva för behandling av exempelvis testikel- och äggstockscancer. För att utforska bakomliggande orsaker har forskningsprojektets utgångspunkt varit att studera kliniskt välkarakteriserade metallbaserade läkemedel som exeGaining a detailed understanding of how human cells are affected by metal-based drugs is crucial, since these drugs have shown great potential in cancer treatment. Cisplatin is used to treat many different types of cancer, e.g. testicular, ovarian, melanoma, bladder, non-small cell lung cancer, small cell lung cancer, myelomas and lymphomas. The miRNA expression profiles in different human cancers
The aim of this study was to investigate sleep, television and computer habits and enjoyment and feelings of tiredness in school of school-age children and adolescents in Sweden. An instrument found to be valid and reliable here was distributed to 3,011 children aged 6, 7, 10, 14, and 16 years. Those sleeping less than the median length of time reported a significantly lower degree of enjoyment of
This study was designed to test the hypothesis that administration of granulocyte colony-stimulating factor (G-CSF; filgrastim) during induction chemotherapy with CHOP (cyclophosphamide, vincristine, doxorubicin, prednisone) or CNOP (doxorubicin replaced with mitoxantrone) in elderly patients with aggressive non-Hodgkin lymphoma (NHL) improves time to treatment failure (TTF), complete remission (C
OBJECTIVES: The objective was to analyse whether a favourable change in risk factors, caused by a comprehensive risk factor modification programme, affected intima-media thickness (IMT) in the common carotid artery, and whether any such change was associated with a change in cardiovascular events during a 6-year follow-up. DESIGN: Patients were randomized 1 : 1 to special intervention or usual car
Objective: To test the hypothesis that sub-optimal factors in perinatal care services resulting in perinatal deaths were more common among immigrant mothers from the Horn of Africa, as compared to Swedish mothers. Design: A perinatal audit, comparing cases of perinatal deaths among children of African immigrants residing in Sweden, with a stratified sample of cases among native Swedish women. Se
Popular Abstract in Swedish Bröstcancer är den vanligast förekommande cancerformen hos kvinnor. Under sin livstid kommer tio procent av den kvinnliga befolkningen att få bröstcancer men endast en minoritet kommer att avlida av den. Operation är den vanligaste behandlingen och kombineras oftast med strålbehandling. Armlymfödem samt nedsatt axelrörlighet och muskelstyrka är välkända sidoeffekter tilTen percent of the female population in Sweden will be diagnosed with breast cancer during their lifetime, but only a minority will die from the disease. Arm lymph oedema is a well-known complication following breast cancer treatment and the incidence varies between about 10% when axillary node dissection is performed and about 40% when axillary radiotherapy is added. The general aim of this thes
Purpose Cholesterol-lowering medication (CLM) has been reported to have a role in preventing breast cancer recurrence. CLM may attenuate signaling through the estrogen receptor by reducing levels of the estrogenic cholesterol metabolite 27-hydroxycholesterol. The impact of endocrine treatment on cholesterol levels and hypercholesterolemia per se may counteract the intended effect of aromatase inhi
Many cities in the world seek to establish more sustainable urban transport systems with a view to reduce accidents, congestion, air and noise pollution, and to improve social interactions, liveability and amenity values. Against this background, this paper frames urban transportation as an issue of justice: contemporary transport systems are characterized by injustice, as they tend to favour and
When looking at energy supply on a larger scale than to a single building, such as to a neighbourhood or a city, the combined effects of peak power demands can be seen to cause problems on the production side. These can be both economic and environmental and lead to the emission of greenhouse gases when fossil fuels are used to meet these peaks. Encouraging the demand side to reduce their power de
The apartment-block of Flagghusen in Malmö in the south of Sweden was built and designed with the intention to achieve a lower energy use compare to the regulations and a good indoor environment. The outcome of this ambition was evaluated in a first report in 2010 that showed that the overall notion of the perceived indoor climate in the apartments were good but that the measured energy use exceed
