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Relapsed or recurrent breast cancer is the chief cause of breast cancer related deaths and it is estimated that one-third of breast cancer patients would likely suffer a relapse. Due to high mortality and incidence, recurrent breast cancer requires better means of prediction, prevention and treatment. The AFFIRM platform uses recombinant antibody technology and selected reaction monitoring (SRM) m
The Brazilian economy is now financialized, where the finance sector and its priorities have become increasingly dominant in all aspects of the economy. At the same time, the country has been facing extremely high levels of inequality and is currently the 8th most unequal country in the world. This thesis aims to analyze the associations between the process of financialization and inequality trend
The furniture market regarding trading with furniture and home decoration products is an expanding market. But despite of good sales the traditional companies are losing market shares. Critical success factors are defined as elements (projects, products, dependants or other factors) that, if not fulfilled will have a great impact on the possibilities of reaching business goals. By defining the com
This essay is about children who have psychological and social problems. An increase part of children and young people in Sweden describe this kind of difficulties. These problems are at the same time a concern for the school as well as the social welfare. The purpose in this essay is to explore if children with psychological and social problems have the same legal rights to education as other chi
In the construction of high-speed railways, an important starting point is to make as little Intrusion on land as possible, therefore it is of high importance to carefully investigate which construction alternatives are the most advantageous. The purpose of this work is to compare and evaluate land use and building on viaduct. The work will be based on literature and interview studies. Sections of
Previous studies clarified that the electron enriched NADH and NADPH by RBC glycolysis could be used in an extracellular chemical reaction, where electron energies are extracted by an electron mediator methylene blue (MB). The reduced form of MB permeates the phospholipid bilayer of liposomes and reduce encapsulated ferric methemoglobin (metHb) to ferrous hemoglobin. Moreover, in vitro screening s
När rubriceringen arbetsmiljöbrott infördes i brottsbalken var det med det uttryckliga syftet att paragrafen skulle ha ett pedagogiskt syfte, att den skulle markera allvarligheten i brottet genom att särskilt peka ut arbetsmiljöansvarigas vidsträckta ansvar samt att säkerställa upprätthållande av risk- och skadeförebyggande verksamhet genom ett effektivt straffrättsligt sanktionssystem med sådan sWhen the work environment crime was introduced in the Swedish Penal Code, it was with the expressed pedagogical purpose that it would highlight the seriousness of the crime by specifically pointing out the work environment managers' extensive responsibility and ensuring maintenance of risk and injury prevention through an effective criminal sanction system with such sharpness that the importan
Even though a number of studies have shown that UV-B radiation inhibits plant growth and regulates the cell cycle progress, little is known about the molecular and cellular mechanisms. Here, we developed a synchronous root-tip cell system to investigate expression changes of cell cycle marker genes and DNA damage under UV-B radiation. Expression analysis of cell cycle marker genes revealed that G1
Nowadays, many evacuation models exist in the market, and new models are continuously released with new features. How to assess the usability and reliability of model results becomes an issue for both developers and users. Therefore, verification and validation (V&V) protocols were introduced in the assessment process of evacuation models. To conduct V&V of a model, a widely accepted test
Mental health services increasingly seek ways to implement Learning Health Systems (LHS) to enhance care quality of patients. This bachelor's thesis focuses on DIALOG+, a structured tool used in psychiatry designed for patient-centered communication. By visualizing and analysing data from DIALOG+, continuous learning can be supported within clinical settings to improve treatment and organizati
Utgångspunkten för uppsatsen är Svea hovrätts uppmärksammade dom i mål B 2457–23 (Swedbank-domen). Domen rörde Swedbanks tidigare vd, Birgitte Bonnesen, som dömdes för grovt svindleri på grund av att hon undanhållit information om misstänkt penningtvätt i bankens estländska verksamhet. Eftersom svindleribrottet sällan prövas i domstol har Swedbank-domen stor betydelse för hur verkställande direktöThe starting point of this thesis is the widely discussed ruling by the Svea court of Appeal in case B 2457–23 (the Swedbank-case). The case concerned Swedbank’s former chief executive officer (CEO), Birgitte Bonnesen, who was convicted of gross swindle for withholding information about suspected money laundering in the bank’s Estonian operations. Since swindle cases are rare, the Swedbank-case is
Den 1 juli 2018 trädde en reformerad våldtäktslagstiftning i kraft i Sverige, där ett uttryckligt krav på frivillighet i 6 kap. 1§ BrB infördes. Denna så kallade samtyckeslagstiftning markerar ett normskifte i synen på sexuealbrott, från fokus på tvång till betoning av sexuell autonomi. Syftet med denna uppsatsen är att klargöra och analysera innebörden av frivillighetsrekvisitet samt att analyserOn July 1st, 2018, a significant reform of Sweden’s rape legislation came into force through the introduction of a consent-based legal framework in Chapter 6, Section 1 of the Swedish Penal Code. This reform marked a paradigmatic shift from coercion-focused regulation toward an emphasis on individual sexual autonomy and voluntary participation. The purpose of this thesis is to clarify and critical
Introduction: Omega-3 fatty acid supplements are widely used as an alternative to eating oily fish. However the polyunsaturated oils they contain are highly susceptible to oxidation, which can lead to rancidity and possibly decreased quality of the supplement. Background: Despite the convenience of omega-3 supplementation, there is limited independent information on the oxidative quality of produ
Objectives: Various outcomes of cholinesterase inhibitor (ChEI) therapy have been observed in Alzheimer’s disease (AD). It is not clear whether the duration of treatment, type of ChEI, or dose affect mortality. We aimed to investigate the association between ChEI therapy and patient survival. Methods: The Swedish Alzheimer Treatment Study (SATS) is a prospective, observational, multicentre study t
Background: Video capsule enteroscopy (VCE) has revolutionized small bowel imaging, enabling visual examination of the mucosa of the entire small bowel, while MR enteroclysis (MRE) and CT enteroclysis (CTE) have largely replaced conventional barium enteroclysis. A new indication for MRE and CTE is the clinical suspicion of small bowel strictures, as indicated by delayed or non-delivery of a test c
Objectives:To determine the cumulative live birth rate (CLBR) under three consecutive in vitro fertilisation (IVF) treatments in women with endometriosis and/or adenomyosis.Methods:A prospective cohort study of 1035 women aged 25–≤39 years undergoing up to three consecutive IVF treatments between January 2019 and April 2024. All women underwent an advanced transvaginal ultrasound examination prior
Background & Aims The risk of hepatocellular carcinoma (HCC) in primary sclerosing cholangitis (PSC) is unclear. Studies indicate a low risk for HCC questioning the rationale for current HCC surveillance guidelines. This study explores the risk of HCC in a longitudinal multicenter cohort with over 3.000 PSC-subjects. Approach & results Subjects with well characterized PSC (n=3.071) were fo
AIMS: Metformin has hitherto not been proven superior to other type 2 diabetes (T2D) medications for the prevention of organ complications. The aim of this study is to report baseline data and blinded interim analyses in the register-based randomised clinical trial (RRCT) SMARTEST, which compares metformin and the SGLT2 inhibitor dapagliflozin in early T2D. We also present learnings from the novel
Objective Blood cell populations, including red blood cells (RBC) unique to the extremely preterm (EPT) infant, are potentially lost due to frequent clinical blood sampling during neonatal intensive care. Currently, neonatal RBC population heterogeneity is not described by measurement of total haemoglobin or haematocrit. We therefore aimed to describe a subpopulation of large RBCs with hyper high
