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Introduction: The fact that the majority of older people wish to remain and live independently in their current homes calls for a more comprehensive understanding of which aspects of the home support healthy ageing. Perceived aspects of home influence life satisfaction, perceived health, independence in daily activities and well-being among people aged 80 years and older. However, health and perce
The variables of snow cover extent (SCE), snow cover duration (SCD), and snow albedo (SAL) are primary factors determining the surface energy balance and hydrological response of the cryosphere, influencing snow pack and glacier mass-balance, melt, and runoff conditions. This study examines spatiotemporal patterns and trends in SCE, SCD, and SAL (2000–2016; 16 years) for central Chilean and Argent
Background: Flu vaccination significantly reduces the risk of serious complications like hospitalization and death among community-dwelling older people, therefore vaccination programmes targeting this population group represent a common policy in developed Countries. Among the determinants of vaccine uptake in older age, a growing literature suggests that social relations can play a major role. M
The aim of the study was to investigate the feasibility of optimizing prophylactic dosing of factor VIII by the use of individual pharmacokinetic data. Twenty-one patients were enrolled in a randomized cross-over study on standard dosage regimens vs. dosing according to pharmacokinetic principles. The study period was 2 x 6 months. Using single-dose pharmacokinetic data for each patient, plasma fa
Through a unique combination of time-resolved single-molecule (cryo-TEM) and bulk measurements (light scattering and small-angle X-ray scattering), we provide a detailed study of the dynamics of stochastic DNA ejection events from phage λ. We reveal that both binding with the specific phage receptor, LamB, and thermo-mechanical destabilization of the portal vertex on the capsid are required for in
BACKGROUND: Although people with intellectual disability (ID) and people with dementia have high drug prescription rates, there is a lack of studies investigating drug use among those with concurrent diagnoses of ID and dementia.AIM: To investigate the use of antipsychotics, benzodiazepine derivatives, and drugs recommended for dementia treatment (anticholinesterases [AChEIs] and memantine) among
Background: In the evolving field of transcatheter aortic valve replacements a new generation of valves have been introduced to clinical practice. With the complexity of the TAVR procedure and the unique aspects of each TAVR device, there is a perceived risk that changing or adding a new valve in a department could lead to a worse outcome for patients, especially during the learning phase. The obj
BACKGROUND: The long-term survival of patients with advanced stage aggressive lymphoma has not improved significantly during the last twenty years. In a randomised trial, the efficacy of MACOP-B, a six-drug weekly chemotherapy regimen, was compared to CHOP, the current standard regimen, in terms of overall and failure-free survival, toxicity and health related quality of life. PATIENTS AND METHODS
Prevention of first time disease or recurrence of coronary heart disease (CHD) is a major task for the health service. Guidelines regarding CHD prevention have been issued but studies have shown that treatment goals are inadequately met in clinical practice and there is urgent need for improved methods of implementation of guidelines. There is also a need for better risk stratification tools in or
Recent studies show that both marine and limnic microalgal species often consist of several genetically distinct populations. This is also valid for the nuisance freshwater algae Gonyostomum semen, which originates from acidic, brown water swamp lakes, but can nowadays also be found in clearer lakes with close to neutral pH. We hypothesized that the observed genetic differentiation among G. semen
Our paper traces the history and progressive development of environmental education and education for sustainable development (ESD) in Sweden and Denmark. Our main focus is on work in primary and lower secondary schools as part of a search for trends of international interest related to the conceptualisation and practice of environmental education and ESD in both countries, as well as the role and
Regional climate models (RCMs) primarily represent physical components of the climate system, omitting vegetation dynamics, ecosystem biogeochemistry and their associated feedbacks. To account for such feedbacks, we implemented a novel plant individual-based vegetation dynamics-ecosystem biogeochemistry scheme within the RCA3 RCM. Variations in leaf area index (LAI) of seven plant functional type
Background: Chronic depression is a particularly disabling mood disorder and treatment outcomes are poor with either psychotherapy or pharmacotherapy alone. There is growing evidence that an integrative treatment approach may be optimal. A novel multi-modal, multi-disciplinary treatment program, Re-ChORD, was developed at the University of British Columbia and evaluated in this pilot study. Method
Although climate is known to play an important role in structuring biological communities, high-resolution analyses of recent climatic impacts on multiple components of diversity are still sparse. Additionally, there is a lack of knowledge about which species drive community response to environmental change. We used a long-term breeding bird data set that encompasses a large latitudinal and altitu
Objective To validate the estimates of Global Burden of Disease (GBD) due to congenital anomaly for Europe by comparing infant mortality data collected by EUROCAT registries with the WHO Mortality Database, and by assessing the significance of stillbirths and terminations of pregnancy for fetal anomaly (TOPFA) in the interpretation of infant mortality statistics. Design, setting and outcome measur
From the 6th to the 9th of November 2016, in the meeting hall of Centro Nacional de Aceleradores(University of Seville, Seville, Spain) took place the “II International Conference onRadioecological Concentration Processes (50 years later)” under the joint organization of theUniversities of Seville (Spain) and Gothenburg (Sweden). With this event, the organization try tocommemorate the fifty years
In Part I of this two-part paper, a formulation was developed to treat fragmentation in ice-ice collisions. In the present Part II, the formulation is implemented in two microphysically advanced cloud models simulating a convective line observed over the U.S. high plains. One model is 2D with a spectral bin microphysics scheme. The other has a hybrid bin-two-moment bulk microphysics scheme in 3D.
Svensk sammanfattningAvhandlingens syfte har varit att studera utvecklingen av en könskromosom i realtid genom att simulera dess framväxt i en hermafroditisk plattmask i laboratoriet. Jag gjorde detta genom att selektera på dels honlig fitness (fitness via ägg), dels hanlig fitness (fitness via spermier) med hjälp av en genetisk markör, som agerade som en könsbestämmande gen. Detta ska efterlikna Sex chromosome evolution in a hermaphrodite ancestor starts with the establishment of a sex-determining region (SDR). Over time, sex-specific genes, and/or sexually antagonistic alleles will become linked to the SDR. Sexually antagonistic alleles are a type of genetic variation that increases fitness for one sex while being detrimental for the other sex. Recombination arrest around the SDR and gen
Recent reports of increasing iron (Fe) concentrations in freshwaters are of concern, given the fundamental role of Fe in biogeochemical processes. Still, little is known about the frequency and geographical distribution of Fe trends or about the underlying drivers. We analyzed temporal trends of Fe concentrations across 340 water bodies distributed over 10 countries in northern Europe and North Am
Many time-series smoothing methods can be used for reducing noise and extracting plant phenological parameters from remotely-sensed data, but there is still no conclusive evidence in favor of one method over others. Here we use moderate-resolution imaging spectroradiometer (MODIS) derived normalized difference vegetation index (NDVI) to investigate five smoothing methods: Savitzky-Golay fitting (S
