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BACKGROUND: Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts. METHODS: We genotyped 16 single-nucleotide polymorphisms (SNPs) and examined clinical factors in 16,061 Swedish and 2770 Finnish subjects. Type 2 diabetes d
Background: Recombinant factor VIIa (rFVIIa) is used to treat bleeds in hemophilia patients with inhibitors. A subcutaneous formulation could potentially improve its half-life and make it suitable for prophylactic treatment. Objectives: A study was conducted to determine the safety of subcutaneously administered rFVIIa in patients with hemophilia and the pharmacokinetic profile (including bioavail
The use of baseline lung function in the prediction of chronic obstructive pulmonary disease (COPD) hospitalisations, all-cause mortality and lung function decline was assessed in the population-based "Men Born in 1914" cohort.Spirometry was assessed at age 55 years in 689 subjects, of whom 392 had spirometry reassessed at age 68 years. The cohort was divided into three groups using fixed ratio (F
Background: It remains unknown if bivalirudin compared to heparin confers any additional inhibition of platelet and coagulation activation during primary percutaneous coronary intervention (PPCI) after pretreatment with ticagrelor. Methods: In this substudy of VALIDATE-SWEDEHEART trial, 103 patients pretreated with ticagrelor were randomized before PPCI to heparin or bivalirudin. Blood samples wer
A 59-year-old female secretary was referred for evaluation and treatment of a non-healing painful ulcer on the medial aspect of her right lower leg. The ulcer had been recurrent almost every year for the past 9 years, often healing during the winter season. She had since early childhood been overweight (currently 87 kg, 170 cm, body mass index 30) and had difficulty in using compression stocking.
A synthesis inversion based on the atmospheric zoom model TM5 is used to derive top-down estimates of CH4 emissions from individual European countries for the year 2001. We employ a model zoom over Europe with 1 degrees x 1 degrees resolution that is two-way nested into the global model domain (with resolution of 6 degrees x 4 degrees). This approach ensures consistent boundary conditions for the
Introduction To prevent further lung damage in patients with acute respiratory distress syndrome ( ARDS), it is important to avoid overdistension and cyclic opening and closing of atelectatic alveoli. Previous studies have demonstrated protective effects of using low tidal volume ( VT), moderate positive end-expiratory pressure and low airway pressure. Aspiration of dead space ( ASPIDS) allows a r
OBJECTIVE: To explore and quantify the relative strengths of the genetic contribution vs the contribution of modifiable environmental factors to severe osteoarthritis (OA) having progressed to total joint arthroplasty.DESIGN: Incident data from the Norwegian Arthroplasty Registry were linked with the Norwegian Twin Registry on the National ID-number in 2014 in a population-based prospective cohort
This is the story of how a large research facility of broad European and global interest, the European Spallation Source (ESS), ended up in the small university town of Lund in Sweden. This happened in spite of the fact that a number of influential European countries were at one time or another competitors to host the facility. It is also a story about politics which attempts to illustrate how clo
Purpose: Although advances in Hodgkin lymphoma (HL) treatment have led to improved disease-free survival, this has been accompanied by an increased risk of second cancers. We sought to quantify the second cancer risks and to investigate the impact of family history. Patients and Methods: Using the Swedish Family-Cancer Project Database, we identified 9,522 individuals with primary HL diagnosed bet
Background Accurate estimation of prognosis in multimorbid hospital patients could improve quality of care. This study aims to determine the relative importance and added value of a performance-based activities of daily living (ADL) measure with regard to mortality prediction. Methods 200 inpatients, aged over 60 years, were recruited at the Department of General Internal Medicine at a tertiary un
Animal eyes typically possess specialized regions for guiding different behavioural tasks within their specific visual habitat. These specializations, and evolutionary changes to them, can be crucial for understanding an animal's ecology. Here, we explore how the visual systems of some of the smallest flying insects, fungus gnats, have adapted to different types of forest habitat over time (approx
The purpose of this essay is to how internal armed conflict in Nepal affected children. Besides that how Nepal has implemented the UN Convention on the Rights of Child during the conflict. It has been estimated that over 2 million children have been killed in armed conflict, another 6 million have been rendered permanently disabled and more than 250, 000 children continue to be exploited as child
Jordens havsnivå förändras ständigt och dessa förändringar kan ha olika orsaker: i ett längre geologiskt tidsperspektiv är det processer i jordens inre som påverkar havsnivån, men i ett kortare perspektiv spelar till exempel tillväxten och avsmältningen av inlandsisar stor roll. Under kvartärtiden har den sistnämnda processen varit den dominerande vad gäller att påverka havsnivåerna: vid istider hResults from an investigation of relative sea-level changes from c. 11,000 cal. yr BP to the present in the Tasiusaq area, Inner Bredefjord, southwest Greenland, are presented in this thesis. Isolation sequences from two small lakes have been identified using stratigraphic analyses, XRF-scanning, loss on ignition and macrofossil analyses. Macrofossil and bulk samples have been dated in order to e
Popular Abstract in Swedish Korrosion av stålarmering i betong orsakade höga reparationskostnader för Ölandsbron, och är en grundläggande fråga vid val av material och utförande för Öresundsbron. Avhandlingen behandlar hur val av betongkvalité och tjocklek hos betongen som skyddar armeringen påverkar dels hur fort saltvatten tränger in i betong för att till slut nå armeringen, dels hur mycket Factors affecting the total chloride threshold for initiation of pitting corrosion in reinforced concrete were investigated by means of field and laboratory exposure tests. Factors affecting the chloride penetration into concrete were also investigated by means of field tests. The thesis consists of a summary (86 p.) and 11 papers attached. Measured total chloride thresholds for uncracked concret
Abstract Title ‘The passion of the consumer’ Seminar date 30/5- 2012 Course BUSN29 Master thesis Author Forat Al Haider Advisor Ulf Elg Keywords Community, Culture capital, Identity, Social links, CCT Thesis purpose The main aim with this research is to contribute to influential and decisive theory within the lines of Consumer behaviour and identity by applying various Consumer Culture theories
Den 30 oktober 2014 erkände Sverige Staten Palestina. Syftet med denna uppsats är att utifrån en folkrättslig metod undersöka de migrationsrättsliga konsekvenserna av detta. De frågor som aktualiseras i detta sammanhang är vilka som nu kan bedömas vara palestinska medborgare samt hur artikel 1 D och 1 C i flyktingkonventionen ska tillämpas till följd av erkännandet. Medborgarskapet får betydelse On October 30, 2014 Sweden recognized the State of Palestine. The purpose of this essay is to examine the legal consequences of this in the field of migration law by applying an international legal method. The questions arising in this context are which individuals that can be considered to be Palestinian citizens and how Article 1 D and 1 C in the Refugee Convention should be applied as a result
The effect of hydrogen enrichment to natural gas flames was experimentally investigated at atmospheric pressure conditions using flame chemiluminescence imaging, planar laser-induced fluorescence of hydroxyl radicals (OH PLIF) and dynamic pressure monitoring. The experiments were performed using a 3rd generation dry low emission (DLE) burner used in both SGT-700 and SGT-800 industrial gas turbines
