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Protein homeostasis in cells, proteostasis, is maintained through several integrated processes and pathways and its dysregulation may mediate pathology in many diseases including Duchenne muscular dystrophy (DMD). Oxidative stress, heat shock proteins, endoplasmic reticulum (ER) stress and its response, i.e. unfolded protein response (UPR), play key roles in proteostasis but their involvement in t
Sustainable energy storage and conversion utforskar innovativa metoder för att effektivt lagra och omvandla energi från olika förnybara källor. Fokus ligger på teknik som avancerade batterier, vätgasproduktion, bränsleceller och termokemiska system samt säkerhetsaspekter på batterilagringssystem. Forskningen syftar till att öka energitätheten, minska kostnaderna och förbättra skalbarheten, vilket
https://www.energy.lth.se/sv/forskning/lagring-och-omvandling-av-energi - 2026-06-25
Design has received increased attention not least of all in the business press and journals. The concept of design thinking – how to approach problems in a designerly way – is sometimes attributed as being the savior of business, making companies creative and innovative. This kind of exaggeration does more harm than good to industrial design consultancies (IDCs) and their client firms (CFs). And y
The purpose of dynamic asset allocation (DAA) is to overcome the challenge that changing market conditions present to traditional strategic asset allocation by adjusting portfolio weights to take advantage of favorable conditions and reduce potential drawdowns. This article proposes a new approach to DAA that is based on detection of change points without fitting a model with a fixed number of reg
BACKGROUND: Tofacitinib is a Janus kinase inhibitor for the treatment of ulcerative colitis (UC). Prospective real-world data are scarce.OBJECTIVES: To collect data on clinical outcomes, including health-related quality of life (HRQoL) and fatigue during treatment with tofacitinib.DESIGN: This is a prospective observational multicentre study in Sweden. In this analysis, outcomes at weeks 2, 8 and
Andrea IossaCollective Autonomy in the European Union – Theoretical, Comparative and Cross-borderPerspectives on the Legal Regulation of Collective BargainingDatum för disputation: onsdagen den 27 september 2017Fakultetsopponent: Associate Professor Aristea Koukiadaki, University of ManchesterÄmne: arbetsrättAbstract‘Collective Autonomy in the European Union’ explores the question of collective au
https://www.jur.lu.se/forskning/disputationer/disputationer-2017 - 2026-06-25
The development of EU labour and social law has been described as a pendulum in the sense of focus shifting between economic interests, such as competitiveness for industry, and social interests, such as improving working and living conditions. This view is to a large extent based on the presumption that those interests are contrasting and pursuing one of them would necessarily exclude the promoti
Untitled Master’s Dissertation Structural Mechanics JUAN CARDENAL BASTÉ Report TV SM -5150 JU A N C A RD EN A L BA STÉ D ESIG N M ETH O D FO R STR U T-B EA M C O N N EC TIO N IN H IN G ED FR A M ES DESIGN METHOD FOR STRUT-BEAM CONNECTION IN HINGED FRAMES Detta är en tom sida! Copyright © 2012 by Structural Mechanics, LTH, Sweden. Printed by Media-Tryck LU, Lund, Sweden, July, 2012 (Pl). For inform
https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5150.pdf - 2026-06-25
In order to move away from fossil fuels many governments and industries are focusing their new investments in electricity and alternative fuels such as green hydrogen from electrolyzers using renewable electricity. High investment costs and electricity costs are a hindrance for the future development of a hydrogen economy which can utilize an increasing intermittent power generation. The aim of th
In the study presented in this paper, a vehicle driving cycle simulation of the pneumatic hybrid has been conducted. The pneumatic hybrid powertrain has been modeled in GT-Power and validated against experimental data. The GT-Power engine model has been linked with a MATLAB/simulink vehicle model. The engine in question is a single-cylinder Scania D12 diesel engine, which has been converted to wor
Streptococcus bovis/Streptococcus equinus complex (SBSEC) is a common cause of infective endocarditis (IE). For IE-pathogens, the capacity to activate and aggregate platelets is believed to be an important virulence mechanism. While the interactions between bacteria and platelets have been described in detail for many Gram-positive pathogens, little research has been carried out with SBSEC in this
This chapter first argues that urban conflicts over peace(s) in the postwar city should be studied through the acts, governing, and spaces underpinning them. It then theorises negotiating agency, governmentality, and relational space as concepts apt for analysing these dimensions. Negotiating agency sees acts are the result of open-ended and constantly on-going negotiations between the subject and
A theory is presented for the service life of concrete exposed to frost action. It is based on a separation of the frost resistance problem in two parts. Part 1, that is only a function of the material itself, and which is expressed in terms of a critical water content, or a degree of saturation, which is a "fracture value" being almost independent of the external conditions (except for the lowest
