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The arteriovenous anastomoses (AVAs) in the distal parts of the extremities play a significant role in the heat exchange with the environment. The aim of the study was to examine the thermal responses to whole-body cooling in air, and especially the behaviour of finger skin temperature (Tf, rich in AVAs). Eight young men sat in minimal clothing at 32°C air temperature (Ta), which was then lowered

To chemically modulate the ubiquitin-proteasome system for degradation of specific target proteins is currently emerging as an alternative therapeutic modality. Earlier we discovered such properties of the stem cell-supporting small molecule UM171 and identified that members of the CoREST complex (RCOR1 and LSD1) are targeted for degradation. UM171 supports the in vitro propagation of hematopoieti

Absorption and emission of photons by any molecule is strongly in uenced by the molecular environment. When several chromophores are packed together their spectral properties are known to be altered and this is canonically ex- plained by quantum theory as electromagnetic interactions between the dipole moments. If the interaction is strong, the absorption process might be best described as the cre

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We extend the ecological component (ECOGEM) of the carbon-centric Grid-Enabled Integrated Earth system model (cGEnIE) to include a diatom functional group. ECOGEM represents plankton community dynamics via a spectrum of ecophysiological traits originally based on size and plankton food web (phyto- and zooplankton; EcoGEnIE 1.0), which we developed here to account for a diatom functional group (Eco

In recent years, hydrogels have been demonstrated as simple and cheap additives to improve the optical properties and material stability of organometal halide perovskites (OHPs), with most research centered on the use of hydrophilic, petrochemical-derived polymers. Here, we investigate the role of a peptide hydrogel in passivating defect sites and improving the stability of methylammonium lead iod

I rättsväsendet är djur att betrakta som saker och egendom. Detta medför att djur, när de är brottsoffer, inte får samma skydd som människor i samma situation. Syftet med denna uppsats har varit att undersöka djurskyddet för häst i Sverige samt den samhälleliga synen på hästen för att se hur väl dessa överensstämmer med det faktum att hästen är att betrakta som en sak i vårt rättssystem. DjurplågIn our judicial system animals are accounted as objects and property. This results in that animals, when victims of crime, do not get the same protection as humans in the same position. The purpose of this essay is to examine the animal protection for horses in Sweden and the view our community has on horses to see how this conforms to the fact that horses are accounted as objects in our judicial

As an increasing number of species drift onto the IUCN’s list of endangered species, it has become increasingly important to understand the fundamental aspects that are essential in maintaining the fitness of these threatened species. Using tracking data from 75% of a sample of Swiss juvenile Red Kites during their wintering period in Spain, various bioclimatic predictors (BCMPs) were taken into

Den som är yngre än 18 år stadgas vara omyndig enligt gällande rätt, men den som är 15 år gammal kan bli föremål för straffrättsliga påföljder om den begått ett brott. Enligt gällande rätt bör dock straffrättsliga påföljder dömas ut mycket restriktivt när lagöverträdare är mellan 15 och 17 år, eftersom vårdande åtgärder angetts erhålla företräde. Enligt barnkonventionen, vilken gäller som svensk lAccording to the Swedish Parental Code (1949:381), chapter 9, section 1, a person below the age of eighteen years is considered a minor. But according to the Swedish Penal Code (1962:700), chapter 1, section 6, a person above the age of fifteen may be subject to sanctions if he or she has committed a crime. According to the Convention on the Rights of the Child, which was incorporated as Swedish l

As social desirability has not received enough focus when estimating the predictive power of personality in explaining well-being variance, recent accounts of the relationship between ratings of personality and well-being might be overestimated. The current study investigated the influence of social desirability, operationalized as the evaluative factor of personality (i.e., the tendency to react

Renewable energy is gaining increasing importance in the generation of power due to the finite existence of fossil fuels and concerns about climate change. As its demand grows financial interest from investors’ increases, thus it is important to find the most effective way of quantifying the risk of the renewable energy market. Furthermore as renewable energy can be viewed as an economic substitut

Per Mårtensson Tillämpning av SCORE-metoden på f.d BT Kemis södra område Syftet med denna uppsats har varit att tillämpa multikriteriaanalysen SCORE för att utreda vilket av tre åtgärdsalternativ som mest gynnar hållbar utveckling vid den kommande saneringen av det södra området på BT Kemi – samt att även utvärdera själva SCORE-metoden. Intresset för hållbar sanering har ökat i takt med att Remediation of contaminated sites may cause adverse negative effects like usage of non-renewable resources, high monetary cost, air emissions and an increased risk of accidents. Therefore, interest in sustainable remediation has increased in recent years. The aim with sustainable remediation is to integrate a holistic perspective on remedial projects and find the alternative that is considered bes

Human carbonyl reductase 1 (CBR1), that is one of the enzymes responsible for the reduced efficiency of treatments by the antineoplastic agents anthracyclines, was functionally expressed in Saccharomyces cerevisiae. CBR1 was purified and kinetically characterised using daunorubicin as substrate. CBR1-catalysed reduction of daunorubicin followed an apparent Michaelis-Menten kinetics with K-M = 85.2

This research aims to develop efficient process technologies that are capable of converting/utilising CO2 streams into energy-rich liquid products (fuels). This would result in better solutions with near-zero-carbon-emissions level. From an energetic and economic point of view, methanol synthesis from CO2 is a competitive alternate to methanol production from biomass. Our work considers the CO2 ba

Peak bone mass is an important risk factor for the development of osteoporosis in later life. Previous work has suggested that genetic, intrauterine, and environmental factors all contribute to the regulation of bone mass, but the ways in which they interact with each other to do so remain poorly understood. In this study, we investigated the relationship between peak bone mass and polymorphisms o

Abstract in UndeterminedRelevant source area of pollen (RSAP) and pollen productivity for 11 key taxa characteristic of the pasture woodland landscape of the Jura Mountains, Switzerland, were estimated using pollen assemblages from moss polsters at 20 sites. To obtain robust pollen productivity estimates (PPEs), we used vegetation survey data at a fine spatial-resolution (1 x 1 m(2)) and randomize

We have studied the convergence of QM/MM calculations with respect to the size of the QM system. We study a proton transfer between a first-sphere cysteine ligand and a second-sphere histidine group in [Ni,Fe] hydrogenase and use a 446-atom model of the protein, treated purely with QM methods as a reference. We have tested 12 different ways to redistribute charges close to the junctions (to avoid

Popular Abstract in English Proteins are a big biological molecules that help cells to function. Proteins play important roles in all vital processes of the living cell, transporting molecules, speeding up chemical reactions, supporting structure of other proteins and the cell, helping the cell to move. Various disease-causing agents (e.g. bacteria and viruses) are constant threat to us. It is thMost drugs act on biomacromolecules. The Cost of developing new drugs is very high. A method to accurately predict binding affinities would be very useful. We have studied molecular mechanics with generalised Born and surface--area solvation (MM/GBSA) and alchemical free energy perturbation methods (FEP) for use in calculations of ligand binding energies. For the MM/GBSA method we have tested: Ca

Enzymes of the xanthine oxidase family are among the best characterized mononuclear molybdenum enzymes. Open questions about their mechanism of transfer of an oxygen atom to the substrate remain. The enzymes share a molybdenum cofactor (Moco) with the metal ion binding a molybdopterin (MPT) molecule via its dithiolene function and terminal sulfur and oxygen groups. For xanthine dehydrogenase (XDH)

The increased survival in malignant cutaneous melanoma (melanoma) is probably due to early diagnosis combined with improved treatment most recently. National health campaigns and screening programs for melanoma detection were started in Sweden several decades ago. We want to assess the influence of tumor characteristics, based on the TNM classification, and of second primary cancers on overall sur