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Integrating continuous atmospheric boundary layer and tower-based flux measurements to advance understanding of land-atmosphere interactions

The atmospheric boundary layer mediates the exchange of energy, matter, and momentum between the land surface and the free troposphere, integrating a range of physical, chemical, and biological processes and is defined as the lowest layer of the atmosphere (ranging from a few meters to 3 km). In this review, we investigate how continuous, automated observations of the atmospheric boundary layer ca

Enzyme Architecture : Modeling the Operation of a Hydrophobic Clamp in Catalysis by Triosephosphate Isomerase

Triosephosphate isomerase (TIM) is a proficient catalyst of the reversible isomerization of dihydroxyacetone phosphate (DHAP) to d-glyceraldehyde phosphate (GAP), via general base catalysis by E165. Historically, this enzyme has been an extremely important model system for understanding the fundamentals of biological catalysis. TIM is activated through an energetically demanding conformational cha

Developing Halogen-Free Polymer Donors for Efficient Nonfullerene Organic Solar Cells by Addition of Highly Electron-Deficient Diketopyrrolopyrrole Unit

High-performance polymer donors when paired with nonfullerene acceptors are mainly limited to flanking halogenated benzodithiophene (BDT)-based π-conjugated copolymers, which however involve complex synthetic procedures. Herein, a series of halogen-free polymer donors that link BDT moiety with two highly electron-deficient benzodithiophene-dione (BDD) and diketopyrrolopyrrole (DPP) units with vari

An finite volume based multigrid preconditioner for dg-sem for convection-diffusion

The goal of our research is the construction of efficient Jacobian-free preconditioners for high order Discontinuous Galerkin (DG) discretizations with implicit time integration. We are motivated by three-dimensional unsteady compressible flow applications, which often result in large stiff systems. Implicit time integrators overcome the impact upon restrictive CFL conditions on explicit ones but

Lattice Engineering via Transition Metal Ions for Boosting Photoluminescence Quantum Yields of Lead-Free Layered Double Perovskite Nanocrystals

Lead-free layered double perovskite nanocrystals (NCs), i.e., Cs4M(II)M(III)2Cl12, have recently attracted increasing attention for potential optoelectronic applications due to their low toxicity, direct bandgap nature, and high structural stability. However, the low photoluminescence quantum yield (PLQY, <1%) or even no observed emissions at room temperature have severely blocked the further deve

O2 consumption, aerobic glycolysis and tissue phosphagen content during activation of the Na+/K+ pump in rat portal vein

Oxygen consumption, lactate production and tissue contents of ATP, phosphocreatine (PCr) and lactate were measured following readdition of K+ to K+-depleted rat portal veins, in order to study the energy turnover associated with Na+/K+ pumping. During incubation in K+-free medium at 37 degrees C spontaneous contractions disappeared in 10-20 min. Readdition of K+ (5.9 mM) after 40 min K+-free incub

Processing of wheat bran to sugar solution

In accordance to better exploitation of raw material for bioethanol production we try to find the method for saccharification of problematic cover part of grain, so called bran. The bran consists of three main components: residual starch, hemicellulose and cellulose. Whereas hydrolysis of starch is easy and well solved, there are questions how to optimise hydrolysis of all polysaccharides together

Rationalisation of the substrate concentration dependent diastereoselectivity of a Saccharomyces cerevisiae short-chain dehydrogenase

The diastereoselectivity of the carbonyl reduction of bicyclo[2.2.2]octane-2,6-dione, catalysed by the purified yeast cytosolic short-chain dehydrogenase Ymr226cp, was shown to be substrate concentration dependent. The changing selectivity was attributed to two distinct binding configurations of the substrate in the active site, each yielding a distinct hydroxy ketone diastereomer. By applying ind

NMR-Derived Models of Amidopyrine and Its Metabolites in Complexes with Rabbit Cytochrome P450 2B4 Reveal a Structural Mechanism of Sequential N-Dealkylation

To understand the molecular basis of sequential N-dealkylation by cytochrome P450 2B enzymes, we studied the binding of amidopyrine (AP) as well as the metabolites of this reaction, desmethylamidopyrine (DMAP) and aminoantipyrine (AAP), using the X-ray crystal structure of rabbit P450 2B4 and two nuclear magnetic resonance (NMR) techniques: saturation transfer difference (STD) spectroscopy and lon

Theoretical Studies of Cytochrome P450

Popular Abstract in Swedish Cytokrom P450 är en stor enzymfamilj som finns i alla levande organismer och tar del i både endogen och exogen metabolism. De är primärt mono-oxygenaser och utför en stor mängd reaktioner. Till skillnad från många andra enzymer har de blivit optimerade för att kunna reagera med många olika substrat, istället för att ha höga reaktionshastigheter. I det aktiva sätet har dThe cytochromes P450 are a large enzyme family that is found in all living organisms and takes part in both endogenous and exogenous metabolism. They are primarily mono-oxygenases and perform a wide range of reactions. In contrast to many other enzymes, they have been optimised to react with a wide range of substrates instead of having high reaction rates. In the active site, these enzymes have a

Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va.

Activated protein C inhibits the procoagulant function of activated factor V (FVa) through proteolytic cleavages at Arg-306, Arg-506, and Arg-679. The cleavage at Arg-506 is kinetically favored but protected by factor Xa (FXa). Protein S has been suggested to annihilate the inhibitory effect of FXa, a proposal that has been challenged. To elucidate the effects of FXa and protein S on the individua

The effect of bone quality on the stability of ankle arthrodesis. A finite element study

Background: Despite uniform operating techniques, lack of fusion still occurs after ankle arthrodesis. Differences in the biological healing potential may be a factor but the mechanical performance of the arthrodesis construct because of varying bone quality also may be important. Internal compression techniques are preferred because of higher union rates, shorter fusion times, and fewer complicat

The Digital IP Challenge Revisited – File-sharing and Copyright Development in Hungary

The emphasis here is the need to understand both the normative gap and the role of digital architecture in order to display the inherent challenge that copyright meets in a digital society. Consequently, in being a descriptively focused study, this article studies contemporary Hungarian copyright and contrasts this to the findings from a survey with over 500 respondents from the Hungarian file-sha

Haptoglobin Binding Stabilizes Hemoglobin Ferryl Iron and the Globin Radical on Tyrosine beta 145

Aim: Hemoglobin (Hb) becomes toxic when released from the erythrocyte. The acute phase protein haptoglobin (Hp) binds avidly to Hb and decreases oxidative damage to Hb itself and to the surrounding proteins and lipids. However, the molecular mechanism underpinning Hp protection is to date unclear. The aim of this study was to use electron paramagnetic resonance (EPR) spectroscopy, stopped flow opt

Solution structure of human prolactin

We report the solution structure of human prolactin determined by NMR spectroscopy. Our result is a significant improvement over a previous structure in terms of number and distribution of distance restraints, regularity of secondary structure, and potential energy. More significantly, the structure is sufficiently different that it leads to different conclusions regarding the mechanism of recepto

Vittnesförhör och bevisvärdering ur ett beteendevetenskapligt och psykologiskt perspektiv

I den rättskipande verksamheten har förhör en central plats. Under förundersökningen bidrar förhör med att driva utredningen framåt och under huvudförhandlingen fungerar dessa som bevisning. I och med den centrala rollen förhör spelar bör det ses som viktigt att dessa bedrivs på ett tillfredsställande sätt. Uppsatsen har ett tvärvetenskapligt perspektiv och undersöker utifrån rättspsykologisk och Interrogation has a central place in the administration of justice. During the preliminary investigation the interrogation is used to move the case forward and during the main hearing the questioning acts as evidence. Due to the central part that the interrogation and questioning takes it should be considered important that it is conducted in a satisfactory way. This thesis has an interdisciplinar

COSM30 Literature 2023

Microsoft Word - 8655F43796B93E8662A613C2DCC1C3EE.docx COSM30 Data Collection and Analysis Literature List Course director and main teacher: Nicholas Loubere Total Pages: 807 Required Reading List Bryman, Alan. 2016. Social Research Methods. Oxford: Oxford University Press. 5th ed. Chapters 7, 8, 9, 10, 11, 12, 23, 26, and 27. • Number of pages: 198 • Price: 487 kr Crawford, Gordon, Lena J. Krucke

https://www.ace.lu.se/sites/ace.lu.se/files/2023-05/COSM30_Literature_2023.pdf - 2026-06-05

Best Master's thesis in economic history

Every spring, about 100 Master's theses are written at the Department. It is a laborious but rewarding task for our students, and it is a dear inconvenience for our teachers to supervise and grade all these theses. Ever since 2014 we select and honour one of them (or sometimes two when the call is close), considered to be the best Master's thesis of the year. 2024 års vinnareTommy Andersson The Cl

https://www.lusem.lu.se/organisation/department-economic-history/study-economic-history/best-masters-thesis-economic-history - 2026-06-03

Blodsjukdomar intressanta för genterapi – Vetenskap och Hälsa

Blodsjukdomar intressanta för genterapi – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Blodsjukdomar intressanta för genterapi 2020-11-06 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Blodsjukdomar är intressanta kandidater för genterapi eftersom blodet e

https://www.vetenskaphalsa.se/blodsjukdomar-intressanta-for-genterapi/ - 2026-06-04