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Background and Purpose-Although many stroke patients are young or middle-aged, risk factor profiles in these age groups are poorly understood. Methods-The Stroke in Young Fabry Patients (sifap1) study prospectively recruited a large multinational European cohort of patients with cerebrovascular events aged 18 to 55 years to establish their prevalence of Fabry disease. In a secondary analysis of pa

To be able to robustly propagate P. falciparum at optimal conditions in vitro is of fundamental importance for genotypic and phenotypic studies of both established and fresh clinical isolates. Cryo-preserved P. falciparum isolates from Ugandan children with severe or uncomplicated malaria were investigated for parasite phenotypes under different in vitro growth conditions or studied directly from

Much is known about the geoepidemiology of defined autoimmune diseases (AD); however, there is currently limited data regarding the prevalence of autoantibodies among healthy populations of different geographical areas. The aim of this study was to evaluate a large profile of autoantibodies in healthy adults from distinct global regions as well as the prevalence of anti-infectious agents antibodie

Background: Type 2 diabetes has been associated with increased incidence of atrial fibrillation (AF) and cardiovascular disease. Controversy remains regarding the role of insulin in the epidemiology of AF risk. The aim of the present study was to study the association between fasting plasma insulin (FPI) and incidence of AF, as well as any effect modification by fasting blood glucose (FBG) or 2 h

The common genetic variants associated with complex traits typically lie in noncoding DNA and may alter gene regulation in a cell type-specific manner. Consequently, the choice of tissue or cell model in the dissection of disease associations is important. We carried out an expression quantitative trait loci (eQTL) study of primary human osteoblasts (HOb) derived from 95 unrelated donors of Swedis

Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 mutations who were diagnosed with invasive breast cancer under age 40 and 1,190 BRCA1 carriers without breast cancer diagnosis over age 35. We took forward 96 SNPs for replication in another 5,986 BRCA1 carriers (2,974 indivi

Populärvetenskaplig sammanfattning: Utvärdering av borrhålsloggar. Syftet med detta examensarbete var att göra en utvärdering av wireline borrhålsloggar från borrhålet Kyrkheddinge-4, 3 km öster om Staffanstorp i Skåne. Den undersökta delen av borrhålet Kyrkheddinge-4 befinner sig inom den potentiella reservoarsandstenen, Lundasandstenen. Wireline borrhålsloggar är geofysiska verktyg som används This study is an evaluation of formation characteristics, as derived from wire-line well logs, of the Lund Member in the borehole Kyrkheddinge-4, 3 km east of Staffanstorp, Skåne, Sweden, through the comparison to measured core data. The purpose is to assess the feasibility of using some of the porosity and permeability equations and cross-plots derived for the investigated section and applying th

According to Lundquist, professor in political science at Lund University, there are six different kinds of steering that rule the activities of the authority. The different kinds of steering can be divided into two different groups&semic direct and indirect steering. Steering by order means that the superior rules how the public authority perform their duty in individual matters. Steering by

På vilka värderingar och grundläggande teorier baserar sig vårt rättsystem och vad är lagens bindande kraft? Hur kan dessa teorier förklara klyftan mellan moraliska regler och lagregler? Denna uppsats består av tre delar. De två första delarna [Kap. 2 och 3] är mer deskriptiva och består dels av ett kapitel om illegal fildelning, dels av en analys av skandinavisk rättsrealism, framför allt VilhelThe general moral attitude is, to consider copyright infringements on the Internet as a socially acceptable behaviour. While the record industry and judicial system have both monetary and other reasons to fight illegal file sharing, both the technological and the moral development are combating these efforts. The legal realism as represented by Vilhelm Lundstedt is based on the idea that the lega

The main purpose of the project has been to find the root cause to the failure of a machine component used to secure some vital parts (later on referred to as the pins) of a packing machine. It was already known that the failure had to do with fatigue, but the actual mechanisms were quite unknown. Measurements on the components did not indicate forces that should lead to failure. The components of

This paper is designed to examine the validity of the CAPM model in the emerging markets. I took the Indian market to be the case in which we examine the applicability of this model and therefore I decided to perform the study on one of the biggest Indian markets; Bombay Stock Exchange. The SENSEX30 was chosen as the examined index and I performed the study on the 28 listed companies in the market

I en tätort söder om Stockholm ligger Karlskronaviken, beläget i ett naturskönt, sjönära område där sommarvillor, fritidshus, egnahem och mindre jordbruk samsats om marken sedan sekelskiftet. Med närheten till Rönninges centrum och dess service samt kollektivtrafik till Stockholm och Södertälje är det inte konstigt att området sedan en tid tillbaka exploateras. Dagens bostadspriser i innerstädernaMy master thesis takes place in an urban, yet rural area south of Stockholm called Karlskronaviken. Located in a scenic, lakeside area where holiday homes, private homes and small farms have shared the land since the turn of the 20th century. With the close distance to the town center of Rönninge, its services and public transport to Stockholm and Södertälje, it is no wonder that the area has been

Geospatial data is becoming increasingly important as artificial intelligence develops rapidly, creating new opportunities in the field of Geographic Information Systems. The thesis investigates the possibility of establishing a method to automatically calibrate a network camera’s geolocation and heading direction by using a camera view image and its corresponding satellite image. The aim is to lo

The aim of this research project was to create a bioinformatic image analysis pipeline for the investigation of lymphocytes in healthy human lungs. The lung is an important organ to study as it provides a fast way for pathogens to enter the body. Therefore, the pulmonary immune system must be further investigated in both healthy and diseased tissue. In order to do comparative studies, we need to c

Background & Aims The risk of hepatocellular carcinoma (HCC) in primary sclerosing cholangitis (PSC) is unclear. Studies indicate a low risk for HCC questioning the rationale for current HCC surveillance guidelines. This study explores the risk of HCC in a longitudinal multicenter cohort with over 3.000 PSC-subjects. Approach & results Subjects with well characterized PSC (n=3.071) were fo

Background: Physical exercise is part of the recommended treatment for individuals with axial spondyloarthritis (axSpA). High-intensity interval training (HIIT) is an effective way to improve cardiovascular health without risk of increased disease activity. Nevertheless, there is a lack of knowledge regarding facilitating factors for digitally-based HIIT among individuals with axSpA. Objective: Th

BACKGROUND: The management of femoral neck fractures (FNF) in elderly patients depends on comorbidities, pre-fracture mobility, any hip joint disease, and life expectancy, with treatment typically involving either hemiarthroplasty (HA) or total hip arthroplasty (THA). While cemented femoral stem fixation is standard, there is no clear consensus regarding cemented versus cementless cup fixation in