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To analyse longitudinal changes in passive range of motion (ROM) in the upper limb in adults with cerebral palsy (CP). Method: Passive ROM for shoulder abduction and flexion, supination, and elbow and wrist extension was analysed in a longitudinal cohort of adults aged 16 to 76 years from the Swedish CP registry. Individual ROM trajectories and mean ROM curves were calculated using the Manual Abil
The timing of the spring season in the boreal region is shifting under global warming, with profound impacts on ecosystems and hydrological processes. However, the mechanisms driving this transition and its considerable interannual variability are not well described, especially regarding the influence of large-scale atmospheric teleconnection patterns. This study examines the temporal variability
Uronate isomerase (EC 5.3.1.12; URI) catalyzes uronate sugar interconversion, a key step in bacterial metabolism, yet its reaction mechanism remains poorly understood. This study delineates the detailed mechanism for the isomerization of d-glucuronate to d-fructuronate catalyzed by a Zn2+-dependent URI enzyme (from Bacillus halodurans). Using quantum mechanical (QM) cluster calculations, three mec
Smart grids are widely promoted as efficient, low-carbon solutions for energy transitions, yet their governance often treats digital infrastructure as immaterial and uniformly beneficial. This obscures the material, temporal, and justice dimensions that shape real-world outcomes. We introduce Circular Grid Governance (CGG), a framework that integrates circular-economy principles, lifecycle thinkin
INTRODUCTION: Autoantibodies against insulin (IAA) are early appearing markers of autoimmunity against the pancreatic islet beta cells and predict progression to type 1 diabetes if additional islet autoantibodies also develop. It is still controversial if proinsulin rather than insulin is the primary autoantibody.METHODS: The aim of the present study was to compare the half-maximal concentration (
Protection of humanitarian aid workers (HAWs) is a challenging task. There are various reports on the topic where much research seems to focus on traditional physical attacks and intentional violence against HAWs (security) rather than the accidental event risks (safety) or discussing it separately. These risks are usually defined by the organization’s security risk management holding the power in
In less than two decades, online dating services have gone from being seen as a marginal and stigmatised practice, to being a regular activity in people's social and romantic lives. This thesis intends to examine Swedish attitudes towards the digital phenomena of online dating and online dating services. The study was conducted through a quantitative method in the form of an online survey, wit
Aim: To explore the possibility of reducing the diagnostic burden in children with prenatally detected unilateral ureteropelvic junction obstruction. Methods: Children with unilateral ureteropelvic junction obstruction (2012–2020) were identified from a prenatal hydronephrosis registry. The frequency of adverse events, predictors for event-free follow-up beyond 1 year of age, and examination burde
In E. coli cells ribosomal small subunit biogenesis is regulated by RNA-protein interactions involving protein S7. S7 initiates the subunit assembly interacting with 16S rRNA. During shift-down of rRNA synthesis level, free S7 inhibits self-translation by interacting with 96 nucleotides long specific region of streptomycin (str) mRNA between cistrons S12 and S7 (intercistron). Many bacteria do not
Obsessive-compulsive disorder (OCD) and anxiety disorders are early-onset mental disorders characterized by selective attention and strong emotional reactions. Attentional bias has been proposed to play a role in the development, onset, and maintenance of the disorders, but few studies have included youth with mental disorders, and no study has included more than one clinical group, making it uncl
Background: Mechanical ventilation (MV), compared to spontaneous breathing (SB), has been found to increase abdominal edema and inflammation in experimental sepsis. Our hypothesis was that in primary acute respiratory distress syndrome (ARDS) MV would enhance inflammation and edema in the abdomen.Methods: Thirteen piglets were randomized into two groups (SB and MV) after the induction of ARDS by l
This study explored serious mental illness (SMI) in young adult offenders imprisoned for violent or sexual crimes, estimating the effects of neurodevelopmental disorders and early-life risk factors on the development of SMI, and its prospective long-term adverse outcomes. An all-male cohort of 266 violent offenders, assessed during imprisonment when aged 18–25 years (M = 21.8, SD = 1.9), was follo
Objectives: The only treatment with curative potential for distal cholangiocarcinoma (dCCA) is radical surgery which can be complemented with adjuvant chemotherapy. The aim of the present study was to perform an independent external validation of a prognostic model for 3-year overall survival based on routine clinicopathological variables for patients treated with pancreatoduodenectomy for dCCA. M
Thioflavin T (ThT) is widely used as a fluorescent probe for amyloid fibrils, yet its fluorescence can also be enhanced in non-fibrillar systems. Here, the photophysical behaviour of ThT was investigated in sodium dodecyl sulfate (SDS), sucrose laurate (SL), sodium caprate (C10), and lanreotide-containing assemblies across acetate (pH 4.0), phosphate (pH 7.4), and Gly-Gly (pH 8.5) buffers using UV
Perceived stigmatization places a large psychosocial burden on patients with some skin conditions. Little is known about the experience of stigmatization across a wide range of skin diseases. This observational cross-sectional study aimed to quantify perceived stigmatization and identify its predictors among patients with a broad spectrum of skin diseases across 17 European countries. Self-report
Introduction: This study focuses on the quantitative analysis of minerals in gummy supplements Background: The content of minerals in gummy supplements can be challenging to measure due to the complex organic matrix that includes, among other ingredients, sugar, glucose syrup, and pectin. Aim(s): The aim of this research project was to validate a method for quantifying Zn, Mg, and Fe in gummy sup
Germline mutations in CDKN2A are frequently identified among melanoma kindreds and are associated with increased atypical nevus counts. However, a clear relationship between pathogenic CDKN2A mutation carriage and other nevus phenotypes including counts of common acquired nevi has not yet been established. Using data from GenoMEL, we investigated the relationships between CDKN2A mutation carriage
