Filtyp
The stem cell factor receptor/c-Kit plays an important physiological role in hematopoesis, melanogenesis and gametogenesis. It has also been implicated in numerous human malignancies. Signal transduction pathways shown to be of importance for c-Kit mediated transformation include the PI3-kinase/Akt pathway. We have previously shown that two alternative splice forms of c-Kit, denoted GNNK- and GNNK
The anaerobic bacterium Finegoldia magna is part of the human commensal microbiota, but is also an important opportunistic pathogen. This bacterium expresses a subtilisin-like serine-proteinase, SufA, which partially degrade the antibacterial chemokine MIG/CXCL9. Here, we show that MIG/CXCL9 is produced by human keratinocytes in response to inflammatory stimuli. In contrast to the virulent human p
Jönsson D, Nebel D, Bratthall G, Nilsson B-O. The human periodontal ligament cell: a fibroblast-like cell acting as an immune cell. J Periodont Res 2010; doi: 10.1111/j.1600-0765.2010.01331.x. © 2010 John Wiley & Sons A/S Background: Periodontal ligament cells are fibroblast-like cells characterized by collagen production but also possessing some osteoblastic features. In the light of numerous
Cholecystokinin (CCK)-expressing basket cells encompass a subclass of inhibitory GABAergic interneurons that regulate memory-forming oscillatory network activity of the hippocampal formation in accordance to the emotional and motivational state of the animal, conveyed onto these cells by respective extrahippocampal afferents. Various excitatory and inhibitory afferent and efferent synapses of the
A cross-sectional study was conducted to assess the extent of unstructured HIV treatment interruptions (TIs) and investigate the effects of socioeconomic, socio-demographic, HIV treatment-related and clinical factors on the magnitude and rate of the same among adult patients at a Kenyan regional referral center. Four hundred and twenty-one adult patients actively receiving antiretroviral therapy a
BACKGROUND: Polyglutamine (polyQ) diseases are characterised by the expansion of CAG triplet repeats in specific genes. The accumulated encoded proteins affect the transcription of numerous transcription factors. We investigated whether polyQ diseases reduce the risk of cancer development. METHODS: Data on patients with the polyQ diseases Huntington's disease (HD), spinobulbar muscular atrophy (
OBJECTIVE: To examine different aggrecanase generated fragments in synovial fluid (SF) from patients with acute and chronic knee injuries and from knee healthy subjects. METHODS: We prepared SF-D1 samples from acute (n=35) and chronic (n=35) knee injury patients and knee healthy subjects (n=10). Aggrecan fragments were analyzed in the SF-D1 samples by quantitative (G1, ARGS, KEEE and G3 antibodies
Summary. Physical activity has been considered as an important factor for bone density and as a factor facilitating prevention of osteoporosis. Bone density has been reported to be reduced in haemophilia. To examine the relation between different aspects of physical activity and bone mineral density (BMD) in patients with severe haemophilia on long-term prophylaxis. The study group consisted of 38
We have explored the potential of cell factory-derived bioactive molecules, isolated from conditioned media of primary goat chondrocytes, for the repair of subchondral cartilage defects. Enzyme-linked immunosorbent assay (ELISA) confirms the presence of transforming growth factor-β1 in an isolated protein fraction (12.56 ± 1.15 ng/mg protein fraction). These bioactive molecules were used alone or
This thesis aims at reconstructing events in the solar system, mainly collisional events in the asteroid belt, by searches for extraterrestrial minerals in Paleogene and Middle Ordovician marine sediments on Earth. Recent empirical evidence show that Earth has experienced a few brief periods during the Phanerozoic when the flux of extraterrestrial matter significantly increased. The most prominent
PURPOSE: To determine if the curve length, curve form, and location of the lower-end vertebra can identify the type of scoliosis. METHODS: Standing posteroanterior and lateral radiographs of 78 women and 27 men with scoliosis aged 8 to 32 years were retrospectively analysed. Parameters measured were (1) the curve length (the number of vertebrae in the main curve), (2) the curve form (C-form, inver
The complex reactions of blood coagulation are balanced by several natural anticoagulants resulting in tuned hemostasis. During several decades, the knowledge base of the natural anticoagulants has greatly increased and we have also learned about antiinflammatory and cytoprotective activities expressed by antithrombin and activated protein C (APC). Some coagulation proteins have also been found to
The CryoGrid community model is a flexible toolbox for simulating the ground thermal regime and the ice-water balance for permafrost and glaciers, extending a well-established suite of permafrost models (CryoGrid 1, 2, and 3). The CryoGrid community model can accommodate a wide variety of application scenarios, which is achieved by fully modular structures through object-oriented programming. Diff
In drug discovery, it is of utmost importance to accurately calculate the free energies of binding ligands to various protein targets, such as enzymes and receptors. We have assessed and used computational tools for this aim, most of them based on molecular dynamics (MD) simulations. We mostly used molecular mechanics (MM) in order to model the protein—ligand interactions, which is more approximat
Food encodes social and cultural values and has an important role to play in defining identities. In mixed populations, diet can be used to distinguish between ‘us’ and ‘them’. This study investigates the extent to which the inhabitants of mediaeval Tallinn, an important trading centre, used food to maintain distinct identities. Human skeletal material was selected from four mediaeval cemeteries i
Markstabilisering blir allt vanligare för exploatering av områden med dålig bärighet.Det finns dock behov av bättre och volymstäckande kontrollmetoder förkvalitetssäkring. Kontrollmetoderna kan delas upp i två steg, där det första sker iomedelbar anslutning till inblandning av bindemedel för att kontrollera om manlyckats behandla hela den avsedda volymen, eller om det finns zoner som behöverkompleSoil stabilisation is becoming increasingly common for the development of areas withpoor bearing capacity. However, there is a need for better and volume-wide controlmethods for quality assurance. The control methods can be divided into two steps,where the first takes place in immediate connection to the mixing of binders to checkwhether the entire intended volume has been successfully treated, or
Phytoplankton have short generation times, flexible reproduction strategies, large population sizes and high standing genetic diversity, traits that should facilitate rapid evolution under directional selection. We quantified local adaptation of copper tolerance in a population of the diatom Skeletonema marinoi from a mining-exposed inlet in the Baltic Sea and in a non-exposed population 100 km aw
Holocene relative shore-level changes and development of the Ģipka palaeolagoon in the western Gulf of Riga are reconstructed using multiproxy analyses by combining litho-, biostratigraphical and chronological data with remote sensing and geophysical data. The results show the development of the Ģipka basin from the Ancylus Lake/Initial Litorina Sea coastal zone (before c. 9.1 cal. ka BP) to coast
Purpose: Avian haemosporidians are widespread parasites, occurring in many bird families and causing pathologies ranging from rather benign infections to highly virulent diseases. The state of knowledge about lineage-specific intensities of haemosporidian infection (i.e., parasitaemia) is mainly based on infection experiments conducted under laboratory conditions. The levels and range of parasitae
