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An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition

Differential effects of tree species identity on rhizospheric bacterial and fungal community richness and composition across multiple trace element-contaminated sites

Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro

EUCAARI ion spectrometer measurements at 12 European sites - analysis of new particle formation events

We present comprehensive results on continuous atmospheric cluster and particle measurements in the size range similar to 1-42 nm within the European Integrated project on Aerosol Cloud Climate and Air Quality interactions (EUCAARI) project. We focused on characterizing the spatial and temporal variation of new particle formation events and relevant particle formation parameters across Europe. Dif

Site Preference and Ordering Induced by Au Substitution in the γ-Brass Related Complex Au-Cr-Zn Phases.

IEA-HIA Task 23 Small Scale Reformers for On-site Hydrogen Supply

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases

Effect of the electrochemical active site on thermal stress in solid oxide fuel cells

The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum : importance of active site metal ions in the binding of substrates and inhibitors

The M17 leucine aminopeptidase of the intraerythrocytic stages of the malaria parasite Plasmodium falciparum (PfLAP) plays a role in releasing amino acids from host hemoglobin that are used for parasite protein synthesis, growth, and development. This enzyme represents a target at which new antimalarials could be designed since metalloaminopeptidase inhibitors prevent the growth of the parasites i

Generalization of prostate cancer classification for multiple sites using deep learning

Deep learning has the potential to drastically increase the accuracy and efficiency of prostate cancer diagnosis, which would be of uttermost use. Today the diagnosis is determined manually from H&E stained specimens using a light microscope. In this paper several different approaches based on convolutional neural networks for prostate cancer classification are presented and compared, using th

Effect of A-/B-site doping on oxygen non-stoichiometry, structure characteristics, and O₂ releasing behavior of La_1−xCa_xCo_1−yFe_yO_3−δ perovskites

Oxy-fuel combustion is one of the proposed technologies with the potential to achieve zero CO2 emission. La1−xCaxCo1−yFeyO3−δ (LCCF) perovskites are promising materials with high selectively for oxygen. In this study, the oxygen non-stoichiometry of perovskites LCCF was investigated by means of iodometric titration. LCCF was prepared using the liquid citrate method, and the phase structures were i

Risk factors and the prevalence of trocar site herniation after laparoscopic fundoplication

Mammalian nest predation induces small-scale nest site switching in territorial tawny owl (Strix aluco) females

Multimethod characterization of a chlorinated solvents contaminated site and geoelectrical monitoring of in-situ bioremediation

Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites

Proteolytic activation is a unique feature of the epithelial sodium channel (ENaC). However, the underlying molecular mechanisms and the physiologically relevant proteases remain to be identified. The serine protease trypsin I can activate ENaC in vitro but is unlikely to be the physiologically relevant activating protease in ENaC-expressing tissues in vivo. Herein, we investigated whether human t

Human encroachment, climate change and the loss of our archaeological organic cultural heritage : Accelerated bone deterioration at Ageröd, a revisited Scandinavian Mesolithic key-site in despair

Coupled water transport and heat flux in seasonally frozen soils : uncertainties identification in multi-site calibration

Quantifying archaeo-organic degradation – A multiproxy approach to understand the accelerated deterioration of the ancient organic cultural heritage at the Swedish Mesolithic site Ageröd

Incorporation of Multinuclear Copper Active Sites into Nitrogen-Doped Graphene for Electrochemical Oxygen Reduction

Java wildcards meet definition-site variance