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Multiple interferon regulatory factor and NF-κB sites cooperate in mediating cell-type- and maturation-specific activation of the human CD83 promoter in dendritic cells

CD83 is one of the best-known surface markers for fully mature dendritic cells (mature DCs), and its cell-type- and maturation-specific regulation makes the CD83 promoter an interesting tool for the genetic modulation of DCs. To determine the mechanisms regulating this DC- and maturation-specific CD83 expression, chromatin immunoprecipitation (ChIP)-on-chip microarray, biocomputational, reporter,

Ischemia-induced upregulation of excitatory amino acid transport sites

Return to Antikythera : Multi-Session SLAM based AUV mapping of a first century BC wreck site

This paper describes an expedition to map a first century B.C. ship wreck off the coast of the Greek island of Antikythera using an Autonomous Underwater Vehicle (AUV) equipped with a high-resolution stereo imaging system. The wreck, first discovered in 1900, has yielded a wealth of important historical artefacts from two previous interventions, including the renowned Antikythera mechanism. The de

The Solution Structures of Mutant Calbindin D_9k's, As Determined by NMR, Show That the Calcium-Binding Site Can Adopt Different Folds

Hydride binding to the active site of [FeFe]-hydrogenase

Effect of exchange of the cysteine molybdenum ligand with selenocysteine on the structure and function of the active site in human sulfite oxidase

Identification of an endothelial cell binding site on kininogen domain D3

Mapping the cell binding site on high molecular weight kininogen domain 5

Shortcomings in current practices for decision-making process and contaminated sites remediation

Defining and applying surrogate safety measures and behavioural indicators through site-based observations

Site-selective ¹³C labeling of histidine and tryptophan using ribose

Role of adenine and guanine sites in hole hopping in dna nanowire

Transfer integrals for oligos with different bases have been calculated using INDO/Koopman's approximation to unveil the charge transport mechanism in DNA. The sequences, G(A)nG, n = 1, 2, …, 10; G(A)xG(A)yG, x + y = 9; and G(A)xG(A)yG(A)zG, x + y + z = 8, were employed to interpret the Guanine (G) and Adenine(A) hopping. Adenine hopping is found to be faster in G(A)nG sequences with longer Adenin

Active-site plasticity revealed in the asymmetric dimer of AnPrx6 the 1-Cys peroxiredoxin and molecular chaperone from Anabaena sp. PCC 7120

Peroxiredoxins (Prxs) are vital regulators of intracellular reactive oxygen species levels in all living organisms. Their activity depends on one or two catalytically active cysteine residues, the peroxidatic Cys (CP) and, if present, the resolving Cys (CR). A detailed catalytic cycle has been derived for typical 2-Cys Prxs, however, little is known about the catalytic cycle of 1-Cys Prxs. We have

A microgel-Pickering emulsion route to colloidal molecules with temperature-tunable interaction sites

Attraction of male turnip moths Agrotis segetum (Lepidoptera : Noctuidae) to sex pheromone components and their mixtures at 11 sites in Europe, Asia, and Africa

Impact of coordinate rotation on eddy covariance fluxes at complex sites

A European aerosol phenomenology -4 : Harmonized concentrations of carbonaceous aerosol at 10 regional background sites across Europe

Although particulate organic and elemental carbon (OC and EC) are important constituents of the suspended atmospheric particulate matter (PM), measurements of OC and EC are much less common and more uncertain than measurements of e.g. the ionic components of PM. In the framework of atmospheric research infrastructures supported by the European Union, actions have been undertaken to determine and m

Preserved leukocyte CD11b expression at the site of interstitial inflammation in patients with high-flux hemodiafiltration

Individual consistency of long-distance migration in a songbird: significant repeatability of autumn route, stopovers and wintering sites but not in timing of migration

Through new tracking techniques, data on timing and routes of migration in long-distance migrant birds are accumulating. However, studies of the consistency of migration of the same individuals between years are still rare in small-sized passerine birds. This type of information is important to understand decisions and migration abilities at the individual level, but also for life history theory,

Geothermal ecosystems as natural climate change experiments : The ForHot research site in Iceland as a case study