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The active-site metal coordination geometry of cadmium-substituted alcohol dehydrogenase : A theoretical interpretation of perturbed angular correlation of γ-ray measurements

The structure of eleven complexes of cadmium-substituted alcohol dehydrogenase with or without coenzyme and with different non-protein cadmium ligands has been estimated by combined quantum chemical and molecular mechanical geometry optimisations. The geometry of the optimised complexes is similar to the crystal structure of cadmium-substituted alcohol dehydrogenase, indicating that the method beh

Site investigation with combined methods in a faulted area in Managua, Nicaragua - a pre-study

Geophysical methods are increasingly being applied to geotechnical investigations, as they can identify material properties and material boundaries, as well as variations in space and time of relatively large volumes of soil. Another advantage is that many of these methods are non-intrusive. The combination of several methods and the verification of their results by sampling and correlating with g

Spatial variability of soil fungal and bacterial abundance: Consequences for carbon turnover along a transition from a forested to clear-cut site

Predicted alterations in belowground plant-allocated C as a result of environmental change may cause compositional shifts in soil microbial communities, and it has been hypothesized that such alterations will influence C mitigation in forest ecosystems. In order to investigate to what degree living trees influence the abundance and activity of mycorrhizal fungi, saprotrophic fungi, and bacteria we

Lorcaserin bidirectionally regulates dopaminergic function site-dependently and disrupts dopamine brain area correlations in rats

Lorcaserin, which is a selective agonist of serotonin2C receptors (5-HT2CRs), is a new FDA-approved anti-obesity drug that has also shown therapeutic promise in other brain disorders, such as addiction and epilepsy. The modulation of dopaminergic function might be critical in the therapeutic effect of lorcaserin, but its exact effect is unknown. Here, we studied the effect of the peripheral admini