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BACKGROUND: Centrally inserted central catheters (CICCs) are indispensable in modern healthcare, but unfortunately, come with complications. Catheter-related thrombosis is a well-known complication reported to occur in 5-30% of patients with CICC. There is a paucity of studies that report the incidence of catheter-related thrombosis after the introduction of real-time ultrasound insertion guidance

IntroductionBeta-lactam antibiotics are essential in the treatment of Gram-negative bloodstream infections. The effect of beta-lactam antibiotics depends on the time of unbound antibiotic concentration above the minimal inhibitory concentration (MIC). An antibiotic concentration above MIC during the whole dosing interval (100% ƒT > MIC) has been suggested as a target for severe infections. The aim

AIMS: There is considerable controversy regarding optimal management of patients with paraesophageal hiatus hernia (pHH). This survey aims at identifying recommended strategies for work-up, surgical therapy, and postoperative follow-up using Delphi methodology.METHODS: We conducted a 2-round, 33-question, web-based Delphi survey on perioperative management (preoperative work-up, surgical procedure

Background: Intra- and interfractional variations in anatomy can cause unplanned substantial alterations of the dose distribution of the target in proton therapy. Motion management methods might be used in order to minimize anatomical variations. In the proton therapy of lung cancer, a potential motion management technique is the use of the voluntary breath-hold approach. The aim of this study was

The overall aim of this thesis is to examine how walking as a transport mode is constructed in the planning realm, affected by the built environment and perceived by the individual. This aim is related to the following research questions: (1) How are pedestrians and walking understood, constructed and perceived in the planning context? (2) How does individual traits and the built environment affec

Uppsatsen berör hur bevisvärderingen och resultatet av denna uttrycks i domskälen i avgöranden från kammarrätter och förvaltningsrätten i mål gäl-lande skattetillägg och mervärdesskatt, och vilka konsekvenser detta har för rättssäkerheten för den enskilde. Uppsatsen grundar sig på den senaste tidens kritik mot Skatteverket och skatteprocessen som bland annat Advokatsamfun-det och Rättvis skatteproThis thesis examines how the evaluation, and the results of such assessment, is articulated in the judicial reasonings delivered by the Administrative Courts of Appeal and Administrative Courts in cases regarding tax surcharges and value-added tax, as well as the implications this has for the taxpayer’s legal certainty. This thesis is prompted by recent criticism directed at the Swedish Tax Agency

I och med elektrifieringen av energisektorn ställs höga krav på ökad inhemsk produktion av elektricitet i Sverige. På grund av den nuvarande fördelningen, där en stor del av produktionen sker i norra Sverige medan konsumtionen är koncentrerad till södra delarna av landet, är behovet extra stort i elområde 4 (SE4). Ett län som möter extra stora utmaningar är Skåne där självförsörjningsgraden för elThe current electrification of the energy sector puts high demands on increasing domestic electricity production in Sweden. This issue is enhanced by the current regional imbalance between supply and demand, while a major share of electricity generation is located in northern Sweden, consumption is concentrated in the south. Consequently, the need for new production is particularly great in electr

Many Swedish multifamily buildings from the 1960s are now reaching a stage where major renovation is needed to improve energy performance, indoor environmental quality, and long-term climate performance. At the same time, renovation strategies may involve trade-offs between operational energy savings, embodied carbon, thermal comfort, and material circularity. This thesis evaluates energy-efficien

A Free-Electron Laser (FEL) is a light source capable of producing extremely brilliant light pulses over a wide spectral bandwidth, with pulse lengths ranging from a few hundred picoseconds down to the femtosecond time scale. These pulses are generated and amplified through the interaction of a relativistic electron beam with a co-propagating radiation field in an undulator, a process either start

The world faces major climate challenges and extensive efforts need to be taken to combat this issue. Replacing fossil-derived fuels and chemicals with renewables are one important step on the way. Hydrogen has a great potential as a renewable energy carrier for the transport sector and as a green chemical for the industry. Today, the production of hydrogen stems primarily from fossil resources. A

The trace element selenium is of essential importance for the synthesis of a set of redox active proteins. We investigated three complementary serum selenium status biomarkers in relation to overall survival and recurrence following diagnosis of primary invasive breast cancer in a large prospective cohort study. The Sweden Cancerome Analysis Network – Breast Initiative (SCAN-B) is a prospective po

Background: Eating disorders (ED) are severe psychiatric conditions, characterized by decreased quality of life and high mortality. However, only a minority of patients with ED seek care and very few receive treatment. Internet-delivered cognitive behavioral therapy (ICBT) has the potential to increase access to evidence-based treatments. Aims: The aims of the present study were to (1) develop and

The clinical evaluation of regional delays in myocardial motion (myocardial asynchrony) has proved problematic, yet it remains an important functional parameter to evaluate. Prior attempts to quantify regional asynergy have met with limited success, often thwarted by the low temporal resolution of imaging-system data acquisition. If a delay in onset of motion of 30-40 msec is clinically important

Background: The burden of Parkinson’s disease (PD) worsens with disease progression. However, the lack of objective and uniform disease classification challenges our understanding of the incremental burden in patients with advanced Parkinson’s disease (APD) and suboptimal medication control. The 5–2-1 criteria was proposed by clinical consensus to identify patients with advancing PD. Our objective

Background Abdominal symptoms are diagnostically challenging to general practitioners (GPs): although common, they may indicate cancer. In a prospective cohort of patients, we examined abdominal symptom frequency, initial diagnostic suspicion, and actions of GPs in response to abdominal symptoms. Methods Over a 10-day period, 493 GPs in Norway, Denmark, Sweden, Belgium, the Netherlands, and Scotla

The diesel engine is one of the most economic power sources and is therefore used in a range of technical solutions. The low fuel consumption combined with high engine performance makes it attractive for transportation vehicles. They are relatively unproblematic in terms of emissions of carbon-monoxide and hydrocarbons but, on the other hand, they are associated with high emissions of nitrogen oxi

The biochemical methane potential (BMP) assays were used as a tool to investigate methane potential of chicken manure (CM) and three co-substrates (chicken processing waste, Miscanthus and seagrass) in mono-digestion and co-digestion studies for selecting regional biomass in a bid to support the expansion of a full-scale biogas plant. Two types of kinetic models (first order and modified Gompertz

We find ourselves in the midst of a remarkable technological revolution, with rapid advancements in fields such as artificial intelligence, robotics and information technology. Consequently, there is a pressing need for low-power technologies that are not reliant on continuous power supply. The field of spintronics aims to resolve this by coupling electric and magnetic properties. To pave the way

Background: Repolarization prolongation can be the earliest electrophysiological change in ischemia, but its role in arrhythmogenesis is unclear. The aim of the present study was to evaluate the early ischemic action potential duration (APD) prolongation concerning its causes, expression in ECG and association with early ischemic ventricular fibrillation (phase 1A VF). Methods: Coronary occlusion

Background: Influenza vaccination early after myocardial infarction (MI) improves prognosis but vaccine effectiveness may differ dependent on type of MI. Methods: A total of 2,571 participants were prospectively enrolled in the Influenza vaccination after myocardial infarction (IAMI) trial and randomly assigned to receive in-hospital inactivated influenza vaccine or saline placebo. The trial was c