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The two major forms of the amyloid-beta (Aβ) peptide found in plaques in patients suffering from Alzheimer's disease, Aβ40 and Aβ42, only differ by two amino acids in the C-terminal region, yet they display markedly different aggregation behavior. The origins of these differences have remained challenging to connect to specific molecular-level processes underlying the aggregation reaction. In this

Background: Topical oestrogen and manual separation are the main treatments for labial adhesions. The aim was to evaluate treatment of labial adhesions and compare the outcome of topical oestrogen treatment with that of manual separation. Method: All girls aged 0-12 years admitted to a tertiary centre for paediatric surgery for labial adhesions were included. The study design was dual: The first p

A map is a combinatorial presentation of map objects and labels providing users with sufficient and useful information. Text placement is the most time-consuming and cumbersome work in a map production process, and many methods have been proposed to automate this process. However, text placement evaluation lacks exploration, especially when artificial intelligence (AI) methods are experiencing pro

Soundcloud is the worlds third largest streaming platform for music. Despite this, the website is riddled with spam comments that disturb user experience. This spam diers much in format and content from the email spam that we are used to seeing, and that most classic spam lters have been developed to detect. On soundcloud, 90% of spam comments are written by users wanting to self-promote their own

This essay examines European Union policy-making in terms of its aims of promoting the Common Good of its citizens. It uses REACH, the new chemical legislation as a case study, since it is a good example of a piece of legislation which has both environmental and economic consequences, and hence pose great problems for legislators in deciding which of the aims for the Common Good to prioritize. It

Ramlösa water has from early in the previous century been produced and bottled. Compared to today, the initial production was modest and it taken some time before sales expanded. Today, 90 million liters of packed water per year is produced and the water reaches markets far beyond Sweden's boundaries. The natural mineral water which Carlsberg Sweden Corp. produces at their plant in Helsingborg

The dilemma of Article 81(1) EC can be described as a fight between control and freedom. Control in the sense that the Commission has taken a formalistic approach on the interpretation of Article 81(1) EC with the result that many agreements are caught by the prohibition. The only way to avoid the automatic nullity of Article 81(2) EC is then through the exemption paragraph, Article 81(3) EC, whic

The automotive industry is currently witnessing a standard battle between the emerging propulsion technologies and the internal combustion engine. Almost all efforts, whether they are initiated by governments or established players of the automotive industry, have been deployed on a small-scale basis. However, an ambitious attempt is currently being made by the venture-backed company Better Place,

Allergic rhinitis is an inflammatory nasal disorder in which a range of different cells participates. A variety of approaches has been used to monitor nasal inflammation objectively to investigate disease processes and to evaluate the effect of therapeutic intervention. These approaches include nasal lavage, nasal cytology, and nasal biopsy, together with the more recently established measurement

Assays detecting antigen (Ag)-specific T-cell responses in immune-mediated processes are increasingly employed to understand disease pathogenesis and "immune staging". The quantity and quality of starting peripheral blood mononuclear cell (PBMC) preparations are important factors in the performance of such assays. We therefore compared final PBMC yield and function by modifying parameters at the b

Tubular ceramic membranes with many, small-diameter feed flow channels have the advantage of being less costly per unit membrane area. For this reason, membranes with many small channels are often favored over those with fewer larger channels. We have theoretically studied how the diameter of the feed flow channels influences the frictional pressure drop, the membrane performance (flux and retenti

Invasive exotic plant species are often expected to benefit exclusively from legacy effects of their litter inputs on soil processes and nutrient availability. However, there are relatively few experimental tests determining how litter of exotic plants affects their own growth conditions compared to congeneric native plant species. Here, we test how the legacy of litter from three exotic plant spe

This paper reports on two-dimensional (2D) and three-dimensional (3D) direct numerical simulations (DNSs) of the auto-ignition process of a lean H-2/air mixture with temperature stratification in a constant volume enclosure. Detailed chemistry and transport properties are taken into account in the simulations. The combined propagation of spontaneous ignition front and deflagration front is identif

Conventional surveillance systems are omnipresent and most are still based on analog techniques. Migrating to the digital domain grants access to the world of digital image processing enabling automation of such systems, which means extracting information from the image stream without human interaction. The resolution, frame rates, and functionality in these systems are continuously increasing alo

A Summary In a large cohort of elderly women followed for 10 years, we found that balance, gait speed, and self-reported history of fall independently predicted fracture. These clinical risk factors are easily evaluated and therefore advantageous in a clinical setting. They would improve fracture risk assessment and thereby also fracture prevention. Introduction The aim of this study was to identi

Experiments with birch bark samples have been carried to enable a distinction between extraction and degradation effects during pressurised hot water extraction. Two samples, E80 and El 80, contained birch bark extracts obtained after extraction at 80 and 180 degrees C for up to 45 min, respectively. Two other samples, P80 and P180, were only extracted for 5 min at the two temperatures and were th

We present new major and trace element, high-precision high-field-strength-element, hafnium and neodymium isotope data for well preserved Eoarchean TTGs within the Itsaq Gneiss Complex (IGC) of southern West Greenland. These data are combined with thermodynamic model predictions of partial melting and fractional crystallization to gain new insights into continental crust formation in the Archean.

Inland waters were recently recognized to be important sources of methane (CH4 ) and carbon dioxide (CO2 ) to the atmosphere, and including inland water emissions in large scale greenhouse gas (GHG) budgets may potentially offset the estimated carbon sink in many areas. However, the lack of GHG flux measurements and well-defined inland water areas for extrapolation, make the magnitude of the poten

We report a dual phase boron nitride (BN) material composed of 50% cubic and 50% wurtzite phases that has the same level of hardness as polycrystalline diamond. The dual phase BN material was initially synthesized from high pressure and high temperature consolidation of powder materials and subsequently, a laser/waterjet heat treatment (LWH) was applied to the material surface. The LWH process con

Popular Abstract in Swedish Det övergripande syftet för den här avhandlingen var att identifiera miljöfaktorer som påverkar barn med ADHD, autism och Downs syndrom och deras förmåga att koncentrera sig i sin lärmiljö i skolan. Målet med den forskning som gjorts här är inte att avskriva några av de extraresurser som barnen ifråga behöver, utan i stället att ge förslag på hur man kan utforma deras lThe overall aim of this thesis was to identify environmental factors that affect children with ADHD, autism, and Down's syndrome and their ability to concentrate in their learning environment at school. The issue of this research is not to dismiss any of the additional resources these children are in need of; instead it is to suggest how to arrange learning environments in the most supportive way