Sökresultat

Framtidens digitalisering av tumöranalyser för bättre behandling och prognos Läkarkonsten är på väg att få fler redskap för att individanpassa cancerbehandlingar och få en bättre patientöverlevnad. Intressant nog kan vi i framtiden komma till att förutsäga tumörers svar på behandling utifrån en matematisk algoritm som med hjälp av uppmätta gen- och proteinnivåer skattar halten av olika immuncelleIntroduction: There is a shortcoming in current breast cancer treatment, where some patients get overtreated leading to unnecessary side effects and others will not respond to the indicated treatment. Immune infiltration appears to have potential to become an important parameter when predicting how the tumour will respond to certain treatments, prognosing the survival rates in different subgroups

Fitting a model to a time-dependent ensemble average is a process repeated frequently throughout biophysics. A selected ensemble-averaged observable (⟨y(t)⟩) for a given system can be predicted through the use of an estimated ensemble average, where the estimated ensemble average is created via simulated or experimental data sets. Fitting a model to this estimated ensemble average allows for estim

The European Union boasts free movement of workers as one of its fundamental freedoms for all citizens. However, this freedom does not exist free from controversy or challenging issues. Professional workers raise unique problems when considering the exercise of this freedom. Member States in which the professionals wish to practice are reasonably concerned with assuring that the professionals prac

The mandatory report legislation under Chapter 14, 1 § Social Services Act, imposes an obligation to report to social services if they suspect child maltreatment. The interest for our thesis topic was brought when we read articles and previous research showing that preschool teachers and well baby nurses do not always notify when they suspect child maltreatment. The aim of this study was to examin

Scientific abstract: As the increasing attentions drawn to the environment and climate change issue, the profound impact on the earth system made known to nearly every corner of the world. A great variety of global protocols and conventions has been established aiming to reduce global environmental risks and maintain a healthy earth system. In order to monitor, supervise these protocols and conven

The purpose of this work has been to perform numerical calculations on the cubical mixing tank the QB mixer, to be able to verify its strength and try to improve it. The QB mixer is produced by the company QB FoodTech AB. Firstly a CAD model was made from drawings of the mixer. Then the structure was analysed in aspects of pressure load, thermal loads and gravitational load. A modal analysis to ge

Rationale: Recovery after heart transplantation is challenging and many heart recipients struggle with various transplant-related symptoms, side-effects of immunosuppressive medications and mental challenges. Fatigue has been reported to be one of the most common and distressing symptoms after heart transplantation and might therefore constitute a barrier to self-efficacy, which acts as a moderato

Epilepsy is one of the most prevalent paroxystic neurological disorders. It is characterized by the occurrence of spontaneous seizures. About 1 out of 3 patients have drug-resistant epilepsy, thus their seizures cannot be controlled by medication. Automatic detection of epileptic seizures can substantially improve the patient's quality of life. To achieve a high-quality model, we have to collect d

Background: Allergy and asthma are closely linked. Inhalation of allergen induces an early allergic response (EAR) within the airways of allergic asthmatic subjects, which is followed by a late allergic response (LAR) in approximately 50% of the subjects. The LAR is defined as a drop in forced expiratory volume in 1 second (FEV1) from baseline usually occurring 4-8 hours after exposure and is beli

Inhibitory control refers to the ability to stop impulses in favor of more appropriate behavior, and it constitutes one of the underlying cognitive functions associated with cognitive flexibility. Much attention has been given to cross-species comparisons of inhibitory control; however, less is known about how and when these abilities develop. Mapping the ontogeny of inhibitory control in differen

Numerous protein biomarkers have been analyzed to improve prognostication in non-small cell lung cancer, but have not yet demonstrated sufficient value to be introduced into clinical practice. Here, we aimed to develop and validate a prognostic model for surgically resected non-small cell lung cancer. A biomarker panel was selected based on (1) prognostic association in published literature, (2) p

Aims: Patterns of species richness, such as the remarkable biodiversity of tropical regions, have been documented and studied for centuries. However, their underlying evolutionary and ecological causes are still incompletely understood. A commonly stated paradigm in the literature is that high richness in some habitats is directly caused by one of three competing explanations: (1) greater time-for

Energy-intensive processing industries like the concrete industry form the base of the economy and account for a large part of global greenhouse gas emissions. Sectoral transformation to cleaner basic materials is therefore crucial, and institutional pressure to do so is increasing. However, socio-technical studies have not sufficiently addressed these sectors. This paper therefore sets out to ana

Context. The radial metallicity distribution in the Galactic thin disc represents a crucial constraint for modelling disc formation and evolution. Open star clusters allow us to derive both the radial metallicity distribution and its evolution over time. Aims. In this paper we perform the first investigation of the present-day radial metallicity distribution based on [Fe/H] determinations in late

The ability to sense the surrounding environment and respond to external fluctuations is a fundamental property of cells, the basic unit of life. Although cells can be very different in their composition and structure, they all have specialized molecular mechanisms that allow them to adapt to their environment, by coordinating gene expression and protein production. In this thesis, we focus on a s

Popular Abstract in Swedish Peptidaser, proteolytiska enzymer eller proteinhydrolaser är olika benämningar på samma sorts enzymer. Deras funktion är att bryta ner proteiner i alla celler, vävnader eller vätskor i antingen vår egen kropp eller i någon annan levande organism. Varför behövs dessa enzymer? Deras funktion påminner om den av en återvinningscentral, där peptidaserna avvecklar felfungera

NOVELTY - Pretreating non-wood lignocellulosic material containing less than 5 wt.% starch or sugar for producing ethanol from lignocellulose, comprises: (a) adding organic acid or organic acid-producing bacteria to the lignocellulosic material; (b) storing the lignocellulosic material in presence of organic acid for at least 2 weeks in an atmosphere of less than 5% oxygen to obtain organic acid-i

This paper presents and discusses results from the research project LETS 2050 that studies the governance challenges of a transition to a low-carbon transport and energy system in Sweden by 2050 (www.lets2050.se ). A key starting point of the project was that a low carbon transition is technically possible and economically feasible, while the main challenge is political. At the moment there is an

Background/Objectives A cascade of gene activations under the control of Notch signalling is required during T-cell specification, when T-cell precursors gradually lose the potential to undertake other fates and become fully committed to the T-cell lineage.We elucidate how the gene/protein dynamics for a core transcriptional module governs this important process by computational means. Methods We