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Altered regulatory T cell phenotype in latent autoimmune diabetes of the adults (LADA)

Latent autoimmune diabetes of the adults (LADA) accounts for up to 12% of all patients with diabetes. Initially the disease resembles type 2 diabetes (T2D); however, the typical presence of β cell autoantibodies indicates an autoimmune basis of LADA. While dysfunctional regulatory T cells (Tregs) have been implicated in autoimmune diabetes, these cells have been scarcely studied in LADA. The aim o

Pressure analysis on two-step high pressure reducing system for hydrogen fuel cell electric vehicle

Hydrogen fuel cell electric vehicle (FCEV) can achieve zero exhaust emission and zero pollution. In order to make FCEV reach a farther travel distance, greater demands are put on its pressure reducing system. In this paper, a two-step high pressure reducing system for FCEV is proposed. The system is made up of two parts, a new high multi-stage pressure reducing valve (HMSPRV) and a multi-stage muf

High Valent Metal Oxo Complexes as Oxidation Catalysts

Grundämnena molybden, wolfram och vanadin spelar viktiga roller i biologiska system. De återfinns bl a i ett antal enzymer, där de genomför s k syreöverföringsreaktioner, d v s de tar en syreatom från en molekyl och överför den till en annan molekyl. Sådana reaktioner är av stor vikt i kemi, eftersom införandet av syre i olika molekyler är viktig vid framställning av många kemikalier som kan använ

Distribution functions of magnetic nanoparticles determined by a numerical inversion method

In the present study, we applied a regularized inversion method to extract the particle size, magnetic moment and relaxation-time distribution of magnetic nanoparticles from small-angle x-ray scattering (SAXS), DC magnetization (DCM) and AC susceptibility (ACS) measurements. For the measurements the particles were colloidally dispersed in water. At first approximation the particles could be assume

Luminometric Label Array for Counting and Differentiation of Bacteria

Methods for simple and fast detection and differentiation of bacterial species are required, for instance, in medicine, water quality monitoring, and the food industry. Here, we have developed a novel label array method for the counting and differentiation of bacterial species. This method is based on the nonspecific interactions of multiple unstable lanthanide chelates and selected chemicals with

Education and Benchmarking Among Physicians May Facilitate Sick-Listing Practice.

Introduction Assessing work ability and sickness certification are considered problematic by many physicians and education and implementation of guidelines to improve knowledge and skills has been requested. Our aim was to study the association between such interventions and physicians' sick-listing practices. Methods A web-based questionnaire was sent to all physicians working in primary care, ps

Circulating tumor cell analysis in patients with progressive castration-resistant prostate cancer

PURPOSE: To better direct targeted therapies to the patients with tumors that express the target, there is an urgent need for blood-based assays that provide expression information on a consistent basis in real time with minimal patient discomfort. We aimed to use immunomagnetic-capture technology to isolate and analyze circulating tumor cells (CTC) from small volumes of peripheral blood of patien

Development of a Novel Method for Evaluation of Interfacial Tension between Polymer Melts

A novel method for the evaluation of interfacial tension of high viscosity polymer melts is described. The method involves the tracking of the shape evolution of a highly deformed droplet of one material imbedded in a second one. This makes it possible to determine the interfacial tension over a relatively short time period. The imbedded material is initially either a fiber or a disk. The techniqu

Generative learning management : A dual-role model for creativity in organizations

Popular Abstract in Swedish Syftet med avhandlingen var att utveckla en modell för ledarskap som påverkar målorienterad social kreativitet i organisationer. Modellen, på engelska benämnd Generative learning management, har två dimensioner: målstyrning genom tilldelning och decentralisering av beslutsrätten över strategiutveckling för att nå målen i analogi med parallell distribution. I rent praktiA main purpose of this thesis was to develop a model of leadership style named Generative Learning Management (GLM), thought to influence goal-oriented interpersonal creativity in organizations, and to test this model. Creativity is a complex consisting of both novelty and usefulness and it is a general mental ability that is determined by the interplay between different regions in a normally func

Systems Analysis to Promote Frames and Mental Models for Sustainable Water Management

In the water sector, there have been numerous failures in projects aiming at sustainable development and there have been some, but less numerous, examples of successes. However, the most striking observation is the near universal failure to learn from these examples. Somehow, scientists and decision makers have allowed the indications of new approaches and opportunities go undetected because they

Affinity biosensors based on a capacitive transducer

Capacitive biosensors were developed for several analytes such as hormones, interleukines, viruses and heavy metal ions. The sensing surfaces were prepared by immobilizing the biorecognition element to self-assembled monolayers (SAMs) on gold. SAMs form spontaneously on gold by adsorption of thiols, sulfides or disulfides. After immobilization of the biorecognition element a long chain hydrocarbon

Chemical Abundances of Main-sequence, Turnoff, Subgiant, and Red Giant Stars from APOGEE Spectra. I. Signatures of Diffusion in the Open Cluster M67

Detailed chemical abundance distributions for 14 elements are derived for eight high-probability stellar members of the solar metallicity old open cluster M67 with an age of ∼4 Gyr. The eight stars consist of four pairs, with each pair occupying a distinct phase of stellar evolution: two G dwarfs, two turnoff stars, two G subgiants, and two red clump (RC) K giants. The abundance analysis uses near

Polyporales brown rot species Fomitopsis pinicola : Enzyme activity profiles, oxalic acid production, and Fe3+-reducing metabolite secretion

Basidiomycota fungi in the order Polyporales are specified to decomposition of dead wood and woody debris and thereby are crucial players in the degradation of organic matter and cycling of carbon in the forest ecosystems. Polyporales wood-decaying species comprise both white rot and brown rot fungi, based on their mode of wood decay. While the white rot fungi are able to attack and decompose all

Low-Resolution Vision-at the Hub of Eye Evolution

Simple roles for photoreception are likely to have preceded more demanding ones such as vision. The driving force behind this evolution is the improvement and elaboration of animal behaviors using photoreceptor input. Because the basic role for all senses aimed at the external world is to guide behavior, we argue here that understanding this "behavioral drive" is essential for unraveling the evolu

Reduced workforce participation 5 years prior to first Parkinson’s disease sick-leave

The importance of understanding the prodromal phase of Parkinson’s disease (PD) by systematic recording of prediagnostic symptoms and reductions in body functions has been highlighted. The aim of this study was to investigate whether persons later diagnosed with PD exhibit increased physician-certified sickness absence 1, 2, and 5 years prior to a first sick-leave episode attributed to PD. A case-

Common measure of quality of life for people with systemic sclerosis across seven European countries : A cross-sectional study

Objectives the aim of this study was to adapt the Systemic Sclerosis Quality of Life Questionnaire (SScQoL) into six European cultures and validate it as a common measure of quality of life in systemic sclerosis (SSc). Methods this was a seven-country (Germany, France, Italy, Poland, Spain, Sweden and UK) cross-sectional study. A forward–backward translation process was used to adapt the English S

Marine ert modeling for the detection of fracture zones

Resistivity measurements in marine environments have already been tested in Norwegian landscapes in in the detection of subsea fracture zones (Lile et al. 1994; Dalsegg, 2012). Yet, most of the produced data have been processed without taking into account the special conditions created by the presence of seawater. Similar studies outside of Norway (Tsourlos et al., 2001; Satriani et al., 2011; Ruc

The Galah Survey : Classification and Diagnostics with t-SNE Reduction of Spectral Information

Galah is an ongoing high-resolution spectroscopic survey with the goal of disentangling the formation history of the Milky Way using the fossil remnants of disrupted star formation sites that are now dispersed around the Galaxy. It is targeting a randomly selected magnitude-limited (V ≤ 14) sample of stars, with the goal of observing one million objects. To date, 300,000 spectra have been obtained

Wishing for deburdening through sustainable control after bariatric surgery

The aim of this study was an in-depth investigation of the change process experienced by patients undergoing bariatric surgery. A prospective interview study was performed prior to as well as 1 and 2 years after surgery. Data analyses of the transcribed interviews were performed by means of the Grounded Theory method. A core category was identified: Wishing for deburdening through a sustainable co