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Since November 2012 all citizens in Uppsala County in Sweden have access to their medical record on the internet sight “my health contacts”. This is the first step in a EU deployment- project where a total of 12 different eHealth services will be launched over time. The IT director of the county has engaged himself in the idea of medical records and other eHealth services since 1997 and has had se
This chapter reassesses the modernization processes at work in Republican China during the Warlord period between 1911 and 1927 by focusing on corporate, public action by non-state interest groups and organizations. In particular, it looks at modes of corporate governing at the interface of business/economy and education: the realm of vocational education. The chapter examines a particularly illum
Critical systems must comply with safety standards in many application domains. This involves gathering safety evidence in the form of artefacts such as safety analyses, system specifications, and testing results. These artefacts can evolve during a system’s lifecycle, and impact analysis might be necessary to guarantee that system safety and compliance are not jeopardised. Although extensive rese
Popular Abstract in Swedish Helicobacter pylori och Chlamydia pneumoniae är två mycket vanliga smittämnen i den svenska befolkningen. De vanliga kliniska manifestationerna är magsår respektive luftvägsinfektioner. På senare tid har det också diskuterats huruvida de kan bana väg för sjukdomsmanifestationer även inom andra organsystem. I många fall har de studeras var för sig men betydligt mera sällHelicobacter pylori and Chlamydia pneumoniae are common infectious agents in the Swedish population, causing gastritis ulcers and respiratory infections. The metabolic syndrome is characterised by overweight, insulin resistance, hypertension, diabetes and dyslipidaemia. Sera from a patient cohort (n=531) originally examined in 1987-89 were investigated for previous infection of H. pylori and C. pn
Anaerobic digestion is a microbially mediated process occurring in nature in the absence of oxygen and other non-carbonaceous electron acceptors. The majority of the carbon of the organic matter degraded in the process is transformed into carbon dioxide and methane. Most of the energy potential of the degraded material is conserved in the methane, thus providing a renewable energy carrier, which c
The aims of this study have been focused on the identification of cell surface structures involved in the induction and regulation of apoptosis. Monoclonal antibodies against the major histocompatibility complex class I (MHC-I) were shown to induce apoptosis when cross-linked on the cell surface of different malignant cells having a pre-B or a myeloid precursor phenotype. The apoptotic response wa
Popular Abstract in Swedish Genom att inta en bärdryck med extra fiber från råg eller havre steg inte blodsockret och insulinnivån lika snabbt jämfört med samma måltid utan fiber i drycken. Dessutom visade ett test två timmar efter havreklimåltiden att avläsningen av insulinrelaterade gener (genuttrycket) hade nedreglerats. Andra gener som påverkades av havremåltiden var kopplade till proteinsynteIt is well established that dietary fibre, especially soluble dietary fibre, has beneficial effects and can prevent diseases associated with the modern lifestyle. This has been explained by the viscous effects of soluble fibre, which can reduce or delay the absorption of carbohydrates and fat in the small intestine, resulting in lower blood concentrations of glucose, insulin and cholesterol. Oats,
Popular Abstract in Swedish Datorer har blivit en viktig del inom den moderna medicinen. Resultat från patientundersökningar såsom bilder, kurvor och mätvärden bearbetas ofta av datorer och presenteras sedan på ett överskådligt sätt för läkaren som grundar sitt svar på bland annat denna information. Denna doktorsavhandling beskriver hur datorn kan hjälpa till vid själva tolkningen av undersökningThe principal purposes of the studies reported in this thesis were to develop new methods to make computerised decision support systems in medicine both more reliable and fully automated. These aims were pursued in the belief that the solution to these problems will lead to an increased clinical use of such systems resulting in benefit to both patient and physician. In the first two studies, meth
Popular Abstract in Swedish Tyfoidfeber är en sjukdom som orsakas av bakterien Salmonella typhi. Denna bakterie, som sprids via vatten eller föda, orsakar buksmärtor, feber och illamående. Om infektionen inte behandlas med antibiotika, kan bakterien sprida sig till blodet och leda till döden. Årligen rapporteras 16 miljoner fall av salmonella i världen och av dessa får ungefär 600 000 dödlig utgånThis study investigates the interaction between dendritic cells (DC) and the Gram negative intracellular bacterium Salmonella typhimurium. Using in vitro and in vivo approaches, the capacity of DC to directly and indirectly present antigens from Salmonella-infected cells, cytokine production by infected DC, and activation of bacteria-specific T cells was analyzed. These studies revealed differenti
Detrusor smooth muscle contains muscarinic receptors of the M-2 (approximate to2/3) and M-3 (approximate to1/3) subtypes. M-3 receptors are mainly responsible for normal micturition contraction, whereas, the role Of M-2 receptors has not yet been clarified. In certain disease states, M-2 receptors may also contribute to bladder contraction. Different muscarinic receptor subtypes can contribute to
Popular Abstract in Swedish Är muslimer så annorlunda jämfört med andra medborgare att de måste leva segregerade och separeras från resten av det svenska samhället? Vad är en muslim och vem skall definiera denna kategori? I den här avhandlingen presenteras huvudaktörerna i diskussionen och deras ideologiska synsätt. Den mångkulturalistiska ideologin är hegemonisk i Sverige när det gäller frågor soAre Muslims so different from other citizens in Sweden, that they have to live in segregation and be separated from the rest of society? What is a Muslim, and who is to define this category? In this thesis, the author presents the main actors in this discussion and their ideological positions. The multiculturalist ideology is hegemonic in Sweden on issues concerned with cultural diversity, and int
Aims Tumour necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, which is implicated in some metabolic disorders and may play a role in the development of cardiovascular disease. We examined whether plasma TNF-alpha is related to established cardiovascular risk indicators, plasma levels of soluble cellular adhesion molecules and carotid artery intima-media thickness determined by ultra
The influence of the latex surface chemistry on the association of latices with different cellulose derivatives has been investigated by means of isothermal calorimetry and electrophoresis. The chemistries of three grades of coating latices differed with regard to the type and amount of vinylic monomer and the level of carboxylation. In addition, a styrene/butadiene latex substantially free from s
Neutron deficient nuclei near Sn-100 have been produced by fragmentation of a 1 (.) A GeV Sn-112 beam. The fragments were separated, identified and stopped in a highly segmented silicon strip detector stack. This detector measured the total energy of emitted beta(+)-particles. gamma-radiation was measured with surrounding detectors. The half-lives for many nuclides have been determined for the fir
In recent years, outcome assessment following different therapeutic procedures has increasingly focused on the patient's perspective. While traditional measures of outcome, including physical examination and imaging diagnostics of the knee are complementary, patient-relevant questionnaires have become more and more important in determining the value of therapeutic procedures. Therefore, there is a
This thesis regards datapath design and analysis at several abstraction levels. Five papers are presented that focus on datapath design for mobile communication systems and design methodologies for such datapaths. Paper I discusses different aspects of Turbo channel decoder design for high speed and low power applications. It is shown that critical path delay is significantly reduced by simple re
For depth of field (DOF) rasterization, it is often desired to have an efficient tile versus triangle test, which can conservatively compute which samples on the lens that need to execute the sample-in-triangle test. We present a novel test for this, which is optimal in the sense that the region on the lens cannot be further reduced. Our test is based on removing half-space regions of the (u, v) -
A novel method to reduce the multiply scattered light contribution to images recorded with planar laser imaging is demonstrated. The technique, structured laser illumination planar imaging (SLIPI), is based on spatially modulated excitation light and is tested here within the dense region of a hollow-cone spray. The main idea is to use a laser sheet that is spatially modulated along the vertical d
Accumulating data suggest that platelets not only regulate thrombosis and haemostasis but also inflammatory processes. Platelets contain numerous potent pro-inflammatory compounds, including the chemokines CCL5 and CXCL4 although their role in acute colitis remains elusive. The aim of this study was to examine the role of platelets and platelet-derived chemokines in acute colitis. Acute colitis wa
