Filtyp
A new type of supermacroporous, monolithic, cryogel affinity adsorbent was developed, allowing the specific capture of urokinase from conditioned media of human fibrosarcoma cell line HT1080. The affinity adsorbent was designed with the objective of using it as a capture column in an integrated perfusion/protein separation bioreactor setup. A comparative study between the utility of this novel cry
This paper describes the sedimentology, morphology and diagenesis of recently discovered Middle Silurian low-relief micro-epikarst from the Klintehamn area on western Gotland (Sweden). The epikarst represents the most distal portion of an unconformity that truncates stratigraphic units across a major part of the Baltic palaeo-basin. It formed in the intertidal area during the late stage of platfor
Gene-environment interactions include exposure to genotoxic compounds from our diet and it is no doubt, that humans are regularly exposed to e.g. food toxicants, not least from cooked foods. This paper reviews briefly four classes of cooked food toxicants, e.g. acrylamide, heterocyclic amines, nitrosamines and polyaromatic hydrocarbons. Many of these compounds have been recognised for decades also
The extent and consequences of global land-cover and land-use change are increasingly apparent. One consequence not so apparent is the altered structure of plants belowground. This paper examines such belowground changes, emphasizing the interaction of altered root distributions with other factors and their treatment in models. Shifts of woody and herbaceous vegetation with deforestation, afforest
Models based on generalized plant physiological theory represent a promising approach for describing vegetation responses to environmental drivers on large scales but must be tested for their ability to reproduce features of real vegetation. We tested the capability of a generalized vegetation model (LPJ-GUESS) to simulate vegetation structural and compositional dynamics under various disturbance
Objective: The aims were to evaluate the frequency and nature of errors in medication when patients are transferred between primary and secondary care. Method: Elderly primary health care patients (> 65 years) living in nursing homes or in their own homes with care provided by the community nursing system, had been admitted to one of two hospitals in southern Sweden, one university hospital and on
Popular Abstract in Swedish Denna doktorsavhandling i ämnet pedagogik utgör en analys av effekter av den pågående kulturella globaliseringen genom att granska två internationella magisterprogram vid Lunds universitet. Studiens syfte är att spåra mönster i en bärande pedagogisk idé för överföring av ett interkulturellt tänkande i tvärkulturella möten genom att utforska, beskriva och försöka förstå The present study is designed to analyze the effects of the ongoing cultural globalization. It utilizes as its empirical setting two special programmes called the International Master's Programme (the IMP,) directed by Lund University in Sweden. The aim of the study is to infer a pedagogic idea for intercultural transmission through cross-cultural encounters by exploring, describing, and comprehen
Popular Abstract in Swedish Varje dag bildas ca 10^12 nya blodceller i människokroppen. Denna enorma produktion av celler utgår från benmärgen och pågår under hela vårt liv. Ytterst sett är denna process beroende av en till antalet liten cellpopulation av sk blodstamceller eller hematopoietiska stamceller. Den enorma potential som vilar i detta system illustreras av det faktum att en enda blodstamHematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and are ultimately responsible for the continuous production of blood cells throughout life. The regulation of HSCs in vivo is tightly regulated by both intrinsic and extrinsic factors. The Smad-signaling pathway is an evolutionary conserved signaling circuitry with critical functions during embryogenesis and throu
Popular Abstract in Swedish Solljusets effekter på abiotiska och bakteriella kolflöden i akvatiska system I denna avhandling behandlar jag solljusets effekter på organiskt material. Jag har analyserat hur solljus förändrar olika sorters löst organiskt kol och partikulärt organiskt kol. Vidare har jag utvärderat de indirekta effekterna som förändringar av löst organiskt kol har på bakterier. SlutlIn this Thesis, I studied some of the current aspects of organic matter photochemistry. I analyzed abiotic phototransformations of several types of dissolved (DOM) and particulate organic matter (POM). I also evaluated the effects of phototransformation of several types of DOM on bacteria. Finally, in a field experiment, I analyzed net effects of solar radiation on organic matter decomposition. DO
In many species, population sex ratios have far-reaching consequences for a wide variety of population-level and behavioural processes and can directly influence sexual selection through differential effects on male and female mating behaviour. Although sex ratios are often treated as more or less stable population characteristics, recent theoretical evidence suggests that sex ratios fluctuate und
Popular Abstract in Swedish Det övergripande syftet med föreliggande studie är att utveckla en bättre förståelse om vad det innebär att vara montessorilärare. Utgångspunkten är lärarnas egna liv- och verksamhetsberättelser. Insamling av data har skett genom loggböcker, intervjuer, skriftliga reflektioner och diskussioner. Analys av lärarnas livsberättelser i samband med övriga data har granskats fThe overall aim of this study has been to come to a better understanding of what it means to be a Montessori teacher, by getting a group of Montessori teachers to reflect on their lives and work. Data exploration has comprised journals, interviews, written reflections and collaborative contextual analysis. Analysis of the teachers' occupational life histories and the findings as a whole have been
Popular Abstract in Swedish I blodet finns röda och vita blodkroppar eller blodceller, som är nödvändiga för vår överlevnad. Blodcellerna utvecklas i benmärgen från gemensamma ursprungsceller, så kallade stamceller och en konstant nyproduktion pågår genom hela livet. Under produktionen av mogna celler tillväxer och delar sig cellerna och får allt mer specialiserade egenskaper. Denna specialisering
Intestinal alkaline sphingomyelinase (alk-SMase) digests sphingomyelin and the process may influence colonic tumorigenesis and cholesterol absorption. We recently identified the gene of human alk-SMase and cloned the cDNA. Cross-species screening of homology in GenBank found a hypothetical rat protein, XP_221184, with 491 amino acid residues, which shares 73% identity with human alk-SMase. Based o
Backscattered scanning electron micrograph and ultra small- and small-angle neutron scattering data have been combined to provide statistically meaningful data on the pore/grain structure and pore evolution of combustion metamorphic complexes from the Hatrurim basin, Israel. Three processes, anti-sintering roughening, alteration of protolith (dehydration, decarbonation, and oxidation) and crystall
Lymphocytic infiltration of different exocrine and non-exocrine epithelia is the pathological hallmark of primary Sjogren's syndrome, whereas involvement of salivary and lachrymal glands with the clinical counterpart of dry eye and dry mouth are the predominant features of the disease, together with fatigue and musculoskeletal pain. In addition, systemic manifestations, like arthritis, skin vascul
Processes of rapid radiation among unicellular eukaryotes are much less studied than among multicellular organisms. We have investigated a lineage of cold-water microeukaryotes (protists) that appear to have diverged recently. This lineage stands in stark contrast to known examples of phylogenetically closely related protists, in which genetic difference is typically larger than morphological diff
To elucidate the molecular requirements for cancer cell internalization of the extracellular cysteine protease inhibitor cystatin C, 12 variants of the protein were produced and used for uptake experiments in MCF-7 cells. Variants with alterations in the cysteine cathepsin binding region ((Δ1-10)-, K5A-, R8G-, (R8G,L9G,V10G)-, (R8G,L9G,V10G, W106G)-, and W106G-cystatin C) were internalized to a ve
Recent data suggest that platelets not only control thrombosis and hemostasis but may also regulate inflammatory processes such as acute pancreatitis. However, the specific role of platelet-derived mediators in the pathophysiology of acute pancreatitis is not known. Herein, we examined the role of CD40 ligand (CD40L, CD154) in different models of acute pancreatitis. Acute pancreatitis was induced
Leukocyte telomere length (LTL) is associated with the aging process and may be related to cognitive aging. Previous studies have shown conflicting results whether LTL is affected in patients with Alzheimer's disease (AD). In this pilot study, we investigated LTL in a well-defined homogeneous mono-center population. Sixty consecutive patients admitted for cognitive impairment to a memory clinic we
Objective: Synovitis is thought to be a secondary phenomenon in the osteoarthritis (OA) process and the menisci might be triggers of localized synovitis. The aim was to assess the cross-sectional associations of posterior horn meniscal damage with perimeniscal synovitis, and with synovitis posterior to the posterior cruciate ligament (PCL) using contrast enhanced (CE) MRI. Design: The Multicenter
