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Gerhard Schurz [2001, Journal for General Philosophy of Science, 32, 65-107] has proposed to reconstruct auxiliary hypothesis addition, e.g., postulation of Neptune to immunize Newtonian mechanics, with concepts from non-monotonous inference to avoid the retention of false predictions that are among the consequence-set of the deductive model. However, the non-monotonous reconstruction retains the
This thesis is about autistic women. It is about how we, as a society, construct and perceive normality and motherhood as a normative ideal for women. It is also about a dis/ability that often goes unnoticed since autism is not defined by any visible markers. Rather, autism is categorized by behaviour considered atypical through the medical gaze. How to make visible the invisible, the in-between
2593Background: PD-1 blockade has demonstrated positive anti-tumor activity across multiple tumor types. While the anti-tumoral response can be substantial and even curative, response rates remain low in many cancer types. Long-lasting responses are only observed in a minority of patients, and additional immunotherapeutic alternatives remain limited for patients who fail to respond or initially re
SUSTAINABILITY WEEK | HÅLLBARHETSVECKAN Hållbarhetsveckan Sustainability week LUND 23–28 APRIL 2018 HÅLLBARHETSVECKAN | SUSTAINABILITY WEEK SUSTAINABILITY WEEK | HÅLLBARHETSVECKAN Från tanke till handling! Välkommen till en inspirerande vecka om hur vi kan gå från tanke till handling mot en hållbar framtid. I år sätter vi bland annat sökarljuset på vår konsumtion och hur den påverkar människor och
https://www.hallbarhet.lu.se/sites/hallbarhet.lu.se/files/hallbarhetsveckan_2018_program_webb.pdf - 2026-05-07
Ändrade levnadsvanor i västerländska länder har lett till en ökning av sjukdomar så som IBS, infektioner i mag- och tarmkanal och allergier. Det har dessutom observerats att mikrofloran förändrats och goda bakterier så som Limosilactobacillus reuteri försvunnit. Mag- och tarmkanalen har därmed förlorat sina goda soldater mot patogena fiender med dysfunktionell balans som resultat. Därför är det inThis master thesis work was performed in collaboration with BioGaia AB, a Swedish biotech- company producing probiotic supplements containing the bacteria Limosilactobacillus reuteri. The products provided by BioGaia contain live microorganisms. Therefore, a method suitable for the correct enumeration of living cells is crucial in probiotic samples and today the so-called plate count method is use
Two sets of ribosome structures have recently led to two different interpretations of what limits the accuracy of codon translation by transfer RNAs. In this review, inspired by this intermezzo at the Ribosome Club, we briefly discuss accuracy amplification by energy driven proofreading and its implementation in genetic code translation. We further discuss general ways by which the monitoring base
Digital kommunikation medför nya möjligheter för privatpersoner och organisationer att kommunicera. Idag kan de i realtid utbyta information och på så sätt komma närmre sina intressenter. Det är dock oklart hur många som känner till vilken effekt deras digitala kommunikation har. Den här studien undersöker hur kommunala organisationer använder, mäter och utvärderar resultaten av sin digitala kommuDigital communication brings new opportunities for communication between organizations and their stakeholders. Digital channels enable exchange of information in real time and organizations recognize the benefits of having close connections to interested parties. It is however unclear how many organizations that know the effect of their digital communication efforts. This study examines how munici
The nervous system is constantly infiltrated by blood-derived sentinels known as perivascular macrophages. Their immediate precursors have not yet been identified in situ and the mechanism that governs their recruitment is mostly unknown. Here, we provide evidence that CD68 (+)GR(-) monocytes can give rise to perivascular macrophages in mice suffering from endotoxemia. After adhesion to the endoth
Disturbed haemostasis is a central finding in severe Streptococcus pyogenes infection. In particular, microthrombi are found both at the local site of infection and at distant sites. Platelets are responsible for maintaining vascular function and haemostasis. We report here that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation. M1 protein is released fr
Popular Abstract in Swedish Hur gör bakterier för att komma undan immunförsvaret? Vi har studerat hur en vanligt förekommande bakterie, grupp A streptokocker, gör för att undvika kroppens immunförsvar vid infektion. Vi har upptäckt enzymer som bidrar till bakteriens förmåga att undvika immunförsvaret genom att avväpna antikroppar. De bakteriella enzymerna kan användas i bioteknisk industri och eveA majority of the proteins of the immune system are glycosylated and the glycans of IgG are essential for its functionality. Bacteria display enzymes that modulate the glycans of the immune system to weaken the host defense and favor bacterial survival. In this thesis we aimed at exploring bacterial modulation of host glycosylation in infection and to evaluate the usefulness of bacterial enzymes i
