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Although much attention in recent years has been devoted to methane (CH4) emissions from northern wetlands, measurement based data sets providing full annual budgets are still limited in number. This study was designed to help fill the gap of year-round measurements of CH4 emissions from subarctic mires. We report continuous eddy correlation CH4 flux measurements made during 2006 and 2007 over the
Objective: Non-obese patients with type 2 diabetes (T2DM) are characterized by predominant defective insulin secretion. However, in non-obese T2DM patients, metformin, targeting insulin resistance. is non-inferior to the prandial insulin secretagogue, repaglinide, controlling overall glycaemia (HbA(1c)). Whether the same apply for postprandial glucose and lipid metabolism is unknown. Here. we comp
BACKGROUND: In clinical practice there is need for a simple and reliable test for determination of impaired renal function. With reductions in GFR, the plasma cystatin C concentration (C, mg/l) will increase earlier than serum creatinine, and it is generally agreed that plasma cystatin C is only little affected by body weight, age or sex. However, some reports indicate that cystatin C may be influ
Background: The link between colorectal cancer (CRC) and type 2 diabetes mellitus (T2D) has been extensively studied. Although it is commonly accepted that T2D is a risk factor for CRC, the underlying mechanisms are still poorly understood. Research Design and Methods:Given that the genetic background contributes to both traits, it is conceivable that genetic variants associated with T2D may also
In the literature, there are several different suggestions as to when the first postoperative pin-site care should be carried out to best prevent pin-site infections during the treatment by external fixation. In a cohort study, we compared the use of antibiotics and complications in patients where the theatre dressing was changed during the first postoperative week with patients where the theatre
Patients with non-obstructive hypertrophic cardiomyopathy (HCM) exhibit myocardial changes which may cause flow inefficiencies not detectable on echocardiogram. We investigated whether left ventricular (LV) kinetic energy (KE) and hemodynamic forces (HDF) on 4D-flow cardiovascular magnetic resonance (CMR) can provide more sensitive measures of flow in non-obstructive HCM.Methods and resultsNinety
Background: COPD management is guided by the respiratory symptom burden, assessed using the modified Medical Research Council (mMRC) scale, the COPD Assessment Test (CAT), or both. Research Question: What are the abilities of mMRC and CAT to detect abnormally high exertional breathlessness on incremental cardiopulmonary cycle exercise testing (CPET) in people with COPD? Study Design and Methods: A
Background: The pathogenesis of COPD is complex and remains poorly understood. The European Respiratory Society Study on Chronic Obstructive Pulmonary Disease (EUROSCOP) investigated long-term effects of budesonide; 18% of the COPD participants were atopic. So far effects of atopy on the long-term course of COPD have not been elucidated. Methods: Factors related to the presence of atopy (positive
1 2024 Plan of Operations for the Centre for Environmental and Climate Science (CEC) Mission The Centre for Environmental and Climate Science (CEC) is to contribute to sustainable local, regional and global development by being an innovative agent for research, education and external engagement in the field of environmental and climate science, with a broad interdisciplinary profile. CEC’s activit
https://www.cec.lu.se/sites/cec.lu.se/files/2024-07/CEC%20Verksamhetsplan%202024%20English.pdf - 2026-07-17
1 Predictors of the Initiation of Islet Autoimmunity, Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study Running Title: Seroconversion, Multiple Autoantibodies and Type 1 Diabetes Jeffrey P. Krischer1 jeffrey.krischer@epi.usf.edu, Xiang Liu1 Xiang.Liu@epi.usf.edu, Åke Lernmark2 Ake.Lernmark@med.lu.se, William A. Hagopian3 wah@uw.edu, Marian J. Rewers4 marian.rewers@cuans
https://www.teddy.lu.se/sites/teddy.lu.se/files/2023-03/145%20Krischer_Diab%20Care_2022_ACCEPTED%20VERSION.pdf - 2026-07-17
Possible heterogeneity of initial pancreatic islet beta‐cell autoimmunity heralding type 1 diabetes Review-Symposium doi: 10.1111/joim.13648 Possible heterogeneity of initial pancreatic islet beta-cell autoimmunity heralding type 1 diabetes Åke Lernmark1 , Beena Akolkar2, William Hagopian3, Jeffrey Krischer4, Richard McIndoe5, Marian Rewers6, Jorma Toppari7, Kendra Vehik4, Anette-G. Ziegler8 & The
https://www.teddy.lu.se/sites/teddy.lu.se/files/2023-11/151_2.pdf - 2026-07-17
The effect of future changes in temperature and precipitation patterns on arctic ecosystem functioning is often assessed using state-of-the-art ecosystem models. Many models however lack detailed representation of wintertime processes, as pointed out by recent studies (Wang et al. 2016, Slater and Lawrence 2013). This bias may influence the derived outputs, such as soil temperature, permafrost ext
Background: The health status of individuals is determined by multiple factors operating at both micro and macro levels and the interactive effects of them. Measures of health inequalities should reflect such determinants explicitly through sources of levels and combining mean differences at group levels and the variation of individuals, for the benefits of decision making and intervention plannin
Background: In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population. Methodology/Principal Findings: The EPIC-InterAct case-cohort study wa
Objectives To study clinical predictors for radiographic progression after 1 year in an early rheumatoid arthritis (RA) trial. Methods In the SWEFOT trial population, disease modifying antirheumatic drug (DMARD) naive RA patients started methotrexate; 3-month responders (DAS28 <3.2) continued (n=147), while non-responders were randomised to addition of sulfasalazine +hydroxychloroquine (n=130) or
OBJECTIVE Patients with latent autoimmune diabetes in adults (LADA) express autoantibodies against the 65-kDa isoform of GAD (GADA). Intervention with recombinant human GAD65 formulated with aluminium hydroxide (GAD-alum) given twice subcutaneously to LADA patients at intervals of 4 weeks was safe and did not compromise beta-cell function in a Phase II clinical trial. GADA affinity has been shown
Background: Frontotemporal dementia (FTD) is recognised as a clinically and morphologically heterogeneous group of interrelated neurodegenerative conditions. One of the subtypes within this disease spectrum is the behavioural variant FTD (bvFTD). This is known to be a varied disorder with a mixture of tau-positive and tau-negative underlying pathologies. The other subtypes include semantic dementi
https://rwi.lu.se/blog-tags/war-crimes/ - 2026-07-17
https://rwi.lu.se/blog-tags/russia/ - 2026-07-17
