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En potentiell biomarkörer för prostatacancer metastaser Prostatacancer (PCa) är den vanligaste cancerformen hos män i industriländer. Då den primära tumören inte längre är en stor utmaning för dagens medicin, är den metastaserande sjukdom den främsta orsaken till cancerrelaterade dödsfall hos dessa män. Trots många olika palliativa behandlingar mot metastaser, finns det ingen tillgänglig behandl
Osteoarthritis is the most common form of arthritis and is expected to become even more prevalent worldwide with an increasingly older and more obese population. The degenerative joint disease, causing pain, swelling and stiffness in the joints, has a complex etiology and knowledge of the pathophysiological mechanisms is still limited. Recent studies have however reported that the meniscus plays a
Fifteen million people lose their lives to stroke and cancer every year. This amounts to one in every four deaths worldwide, making these among the deadliest diseases affecting humankind. Fruitful attempts at containing stroke- and cancer-related mortality hinge on early detection. Diffusion MRI (dMRI) is an imaging modality that is sensitive to tissue microstructure, and therefore unveils tissue
Peptider är sammankopplade aminosyror som bildar specifika sekvenser med viktiga funktioner. Det som gör dem betydelsefulla är deras roll i att reglera kroppens funktioner genom olika mekanismer. Dessa funktioner kan inkludera reglering av blodsockernivåer, hormonproduktion eller humör. Peptider är något alla människor behöver för att kunna leva. På grund av deras betydelse vill man kunna framstSolid-phase peptide synthesis (SPPS) is the most widely used method for producing synthetic peptides, with the solid support-known as the resin-being a critical component of the process. Redstone Separations AB, a company based in Lomma, Sweden, has developed new SPPS resins and aims to evaluate their performance compared to commercially available alternatives. In this study, Redstone ́s resins w
Dagens samhälle präglas av globalisering och gränsöverskridande handel. I vår del av världen verkar EU och den fria rörligheten som inte bara ger människor och företag rättigheter utan även påverkar våra skatter. I centrum för handeln återfinns företagen, stora som små, som vågar ta klivet över till andra marknader för att se om de klarar av konkurrensen och på sikt öka vinsten då nya marknader inToday’s society is globalised with international trade as a consequence. In our part of the world the EU with it’s advantages and disadvantages concerning the free movement of capital, people and business affects us all, but also our taxes. Companies, big and small are in the centre of the cross-border trade with their expansion into new markets. Business adventures of this kind can generate incre
The vegetation component in climate models has advanced since the late 1960s from a uniform prescription of surface parameters to plant functional types (PFTs) PFTs are used in global land-surface models to provide parameter values for every model grid cell With a simple photosynthesis model we derive parameters for all site years within the Fluxnet eddy covariance data set We compare the model pa
Ecosystem phenology plays an important role in carbon exchange processes and can be derived from continuous records of carbon dioxide (CO2) exchange data. In this study we examined the potential use of phenological indices for characterizing cumulative annual CO2 exchange in four contrasting northern peatland ecosystems. We used the approach of Jonsson and Eklundh (2004) to derive a set of phenolo
Electrochemical real-time monitoring of ligand binding to an engineered opioid receptor specific for morphine is reported. In the particular systems studied, 90% of the binding was found to be completed after only 85-120 s. Thus, the binding kinetics has proven to be more rapid than previously believed. The observed association rate constant for the morphine binding reaction was calculated to be 2
Particulate methane monooxygenase (pMMO) is an enzyme that converts methane into methanol at ambient temperature and pressure. Over the past three decades, the metal content and location of the active site have been highly controversial. Recent single-particle cryogenic electron-microscopy (cryo-EM) structures have furthered this debate. In this study, three cryo-EM structures (PDB entries 7s4h, 7
As CO2 builds up in the atmosphere causing global climate change (IPCC, 2022) trees have become an international symbol of combatting this, and for good reason. Trees take up CO2 which as a result combats these changes, and when these trees are cut down fewer individuals remain to take up the CO2 that we humans emit (Chapin et al., 2011). This means that clear-cut areas don’t act as the carbon sin
Den gängrelaterade brottsligheten har ökat kraftigt i Sverige. Regeringen har av denna anledning infört visitationszoner som ett verktyg för att bekämpa detta. Inom zonen ska polisen få utökade befogenheter att söka efter vapen och andra farliga föremål på människor och fordon utan konkret brottsmiss-tanke. Visitationszoner är ett komplext problem där många starka intressen står mot varandra. UppsGang-related crime has increased significaly in Sweden. For this reason, the government has introduced visitation zones as a tool to combat this issue. Within this zone, the police will be given extended authority to search for weapons and other dangerous objects on people and vehicles without concrete suspicion of crime. Visitation zones pose a complex issue where many strong interests stand agai
Estimating temporal trends in spatially structured populations has a critical role to play in understanding regional changes in biological populations and developing management strategies. Designing effective monitoring programmes to estimate these trends requires important decisions to be made about how to allocate sampling effort among spatial replicates (i.e. number of sites) and temporal repli
INTRODUCTION: Tau positron emission tomography (PET) is a reliable neuroimaging technique for assessing regional load of tau pathology in the brain, but its routine clinical use is limited by cost and accessibility barriers. METHODS: We thoroughly investigated the ability of various machine learning models to predict clinically useful tau-PET composites (load and laterality index) from low-cost an
Ehealth181130Intro eHealth – what is needed for research to reach clinical benefit? Patrik Midlöv, Head of Department of Clinical Sciences Malmö Health and eHealth WHO: Health is a state of complete physical, mental and social well- being and not merely the absence of disease or infirmity. eHealth is the use of information and communication technologies (ICT) for health Swedish government’s vision
https://www.ludc.lu.se/sites/ludc.lu.se/files/1._midlov_intro_20181130.pdf - 2026-05-20
Dear Customer, a new batch is now ready for sale – 010922 211. Unfortunately, we need to increase the price per bottle of 250 tablets to cover the production costs. Orders of 1-4 bottles: 4 000 SEK per bottle + postage Orders of 5-9 bottles: 3 500 SEK per bottle + postage Orders of 10 or more bottles: 3000 SEK bottle + postage Postage cost depends on size and weight of the package, and how central
https://www.geologi.lu.se/sites/geologi.lu.se/files/2023-02/Ny%20batch%20hemsidan%202023.pdf - 2026-05-20
Instruction for external experts regarding programme evaluation at the Faculty of Social Sciences Page 1 of 7 Faculty Board DECISION Reg. No. STYR 2021/118 2021-02-04 Instruction for external experts regarding programme evaluation at the Faculty of Social Sciences This decision enters into force on 4 February 2021 and replace and invalidate the previous decision on Instructions for external expert
Uppkomsten av läkemedelsproteiner har haft betydelsefull påverkan på läkemedelsindustrin. Så kallad PEGylering är en vanlig efterbehandling av dessa proteiner. Idag kännetecknas PEGylering av en stillastående process som är tidsödande med stora förluster. Kan man med nytänk ämnas lösa dessa problem? Tillverkningsprocessen och användningen av terapeutiska (läkande) proteiner har varit relativt fraSince the rise of therapeutical proteins, there has been a growing interest in biopharmaceuticals over the years. Research was made to combat various protein weaknesses like fast degradation and low solubility. A discovery in the 1970s suggested that an attachment of polyethylene glycol (PEG) on protein surfaces would solve the specific problems. Today this process is known as PEGylation and is wi
Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous malignancy which poses a challenge for treatment efficiency. To better stratify DLBCL patients and optimize treatment protocols, we analyzed the serum proteome using samples from a population-based cohort of DLBCL patients. Our objective was to find association between serum protein expression with clinical parameters such as overall
