Filtyp
This thesis demonstrates the usefulness of sedimentary pigments as biomarkers of environmental change in estuarine systems and as biomarkers in lakes in relation to climate change. These are two fields where sediment pigment records as measured by high-performance liquid chromatography (HPLC) are emerging areas of study. A detailed study was undertaken to examine the effects of different storage o
Accident prediction models are often used to predict the number of accidents on segments and at intersections in the road network. Most often the models are developed for a total number of crashes for the facility, or crashes by severity. However, the frequency and severity of crashes of different types can be expected to vary with regards to the underlying phenomena that cause them to occur. To b
Popular Abstract in Swedish Vad är det för något i human mjölk som dödar cancer celler? Kan “fel” veckade proteiner vara nyttiga? Kan fett vara inblandat i protein veckning? Det är några av frågorna som tas upp i denna avhandling. Allt levande består av proteiner som i sin tur är uppbyggda av amino syror. Det finns 20 st. olika amino syror som på olika sätt kan länkas samman till proteinkedjor. DBy varying its secondary or tertiary structure a single protein can attain new biological functions. The amyloid forming proteins are the best known examples where a change in conformation leads to the formation of amyloid fibrils that accumulate in tissues and cause disease. a-lactalbumin in contrast, is an example of a protein that acquires a beneficial function when the conformation is altered
Mangroves provide numerous environmental benefits, such as carbon sequestration, water purification, climate change mitigation, and flood and Tsunami impact reduction. Despite these unique advantages, mangroves are threatened by the combined adverse impacts of human activities and climate change. Therefore, it is essential to implement reasonable practices to avoid further degradation of mangroves
3D-modeller är grunden i det som kallas BIM och är något som används mer flitigt inom byggbranschen men desto mindre inom anläggningsprojekt. BIM har utvecklats mer och mer för att underlätta samordningen av flera aktörer och lösa konflikter i olika faser och skeden. Med ytterligare dimensioner integreras även tid och kostnadsaspekten på projektet som resulterar i ett mer produktivt byggande. Gru3D-models are the base of what is called BIM. It is used more and more within in the construction industry over all, but not as much in the field of infrastructure projects. BIM is developed to coordinate several actors and resolve conflicts in different phases of the construction. With dimensions integrated in the model, such as time and cost aspect, it result in a more productive project. The m
Vad spelar Arktis för roll i klimatförändringarna? Denna avlägsna, och glest befolkade, del av världen utgör faktiskt en viktig del av klimatsystemet. Arktis spelar en betydande roll i kolets kretslopp; vilket innefattar såväl koldioxid och metan, två av de viktigaste växthusgaserna. Förändringar i koncentrationer av växthusgaser påverkar hur mycket värme som hålls kvar i jordens atmosfär. VåtmarkMethane is one of the most important greenhouse gases, and the Arctic region plays an important role in its dynamics. Due to limited observations in this remote and often harsh environments, large uncertainties surround the role of the Arctic region in a warming climate. In this thesis, I examine the performance of the three low-cost solid state sensors, Figaro sensors TGS2600-B00, TGS2611-C00 an
Stability is a fundamental property affecting function, activity, and regulation of biomolecules. Stability changes are often found for mutated proteins involved in diseases. Stability predictors computationally predict protein-stability changes caused by mutations. We performed a systematic analysis of 11 online stability predictors' performances. These predictors are CUPSAT, Dmutant, FoldX, I-Mu
Accident prediction models are often used to predict the number of accidents on segments and at intersections in the road network. Most often the models are developed for a total number of crashes for the facility, or crashes by severity. However, the frequency and severity of crashes of different types can be expected to vary with regards to the underlying phenomena that cause them to occur. To b
During the course of this three-year project, we have studied aeolian deposits at 70 sites within sixteen areas in south-central Sweden. Inland dunes have been the focus, but some sites with coversand and coastal dunes have also been investigated. We have mapped dune morphology, mainly by LiDAR-based remote sensing, studied the internal sediment architecture by ground-penetrating radar profiling a
The active site of sulfite reductase (SiR) consists of an unusual siroheme–Fe4S4 assembly coupled via a cysteinate sulfur, and serves for multi-electron reduction reactions. Clear explanations have not been demonstrated for the reasons behind the choice of siroheme (vs. other types of heme) or for the single-atom coupling to an Fe4S4 center (as opposed to simple adjacency or to coupling via chains
Matching habitat choice is a habitat preference mechanism based on self-assessment of local performance, such that individuals settle in the habitats that are best suited to their phenotypes, promoting local adaptation. Despite the important evolutionary implications of matching habitat choice, examples from natural populations are rare. One possible reason for this apparent rarity is that phenoty
Antigenic diversity in pathogenic microbes can be a result of at least three different processes: diversifying selection by acquired immunity, host–pathogen coevolution and/or host specialization. Here, we investigate whether host specialization drives diversity at ospC (which encodes an immunodominant surface protein) in the tick-transmitted bacterium Borrelia afzelii. We determined prevalence an
Popular Abstract in Swedish Alzheimers sjukdom (eng. Alzheimer’s disease, AD) är den vanligaste orsaken till de- mens. Demens innebär en permanent sänkning av intellektuella förmågor som påverkar individen påtagligt i vardagen. Förekomsten av demenssjukdomar ökar betydligt efter 65 års ålder. AD är en långsamt progredierande sjukdom, som oftast börjar med försämrat närminne. Redan idag är AD en beBackground: Alzheimer’s disease (AD) is the most common cause of dementia. In order to have effect of future disease-modifying therapies for AD, the disease must be identified early, before the patients have developed dementia. Many patients with Mild Cognitive Impairment (MCI) have prodromal AD, but other causes for the syndrome are common. No diagnostic method can identify AD in patients with MC
Popular Abstract in Swedish De flesta barn som insjuknar i epilepsi tillfrisknar eller blir anfallsfria med hjälp av antiepileptisk medicin. Hos drygt en fjärde del av barnen blir epilepsin svårbehandlad och anfallskontroll är svår att uppnå. Dessa barn ska i första hand erbjudas möjlighet till epilepsikirurgisk utredning och behandling. När epilepsikirurgisk behandling inte är möjlig att utföra eWhen anti-epileptic drugs fail, and epilepsy surgery is found unfeasible or ineffective, there remains a group of at least 25% of children with epilepsy in whom seizure control cannot be achieved. Vagus nerve stimulation (VNS) is an adjunctive treatment for medically refractory epilepsy. It is an implantable, multi-programmable pulse generator that delivers current electrical stimulation to the va
In the present thesis, we have examined the in vivo properties of in vitro expanded human and rat neural stem-and progenitor cells after transplantation into the neonatal and adult rat brain. The survival and differentiation of the grafted cells were assessed using species-specific antisera, and pre-labelling with the reporter gene green fluorescent protein (GFP). Long-term growth factor-expanded
Popular Abstract in Swedish På utsidan av insidan - slemmet i tarmen Kroppens slemhinnor, till exempel de i magsäcken och tarmen, täcks av ett slemlager. Slemmet skyddar cellerna i slemhinnan från skadliga ämnen och mikroorganismer genom att ‘fånga’ dem och därmed hindra dem från att nå fram till cellerna. Slemmet är uppbyggt av stora, trådlika och ’klistriga’ molekyler, så kallade muciner, som gHighly glycosylated glycoproteins – mucins – are the major constituents of the mucus layer and glycocalyx that cover mucosal surfaces. Twelve human mucin genes have been identified, and the mucins may be divided into those that are membraneassociated and those that are secreted. Among the latter, the oligomeric mucins are responsible for mucus formation. The various tissues have characteristic muc
The etiology of childhood cancer is largely unknown. Approximately 1-10% of all childhood tumors are associated with known cancer predisposition syndromes. However, the contribution may be underestimated due to the failure to detect patients with genetic susceptibility for cancer when relying on known family pattern and anomalies. Growing evidence indicates that patients with genetic susceptibilit
Introduction: Older patients’ knowledge about their medicines is generally poor. Patients are entitled to be informed on an individual and adequate level. Evidence-based guidelines should, in most cases, be followed also in the treatment of elderly to avoid suboptimal treatment, for example for cardiovascular conditions, or risky prescriptions in the case of renal impairment. Objectives: 1. To de
Popular Abstract in Swedish Analytisk kemi är den gren inom kemin där man studerar, utvecklar och använder metoder och tekniker för att undersöka olika ämnens kemiska innehåll och exakta sammansättning. Den analytiska kemin spelar en mycket central roll inom många vitt skilda vetenskapliga fält och utgör den grund på vilka alla kemiska analyser vilar – medicinska tester och studier, kvalitetskontrFuelled by the current demands of the biological sciences, there is today a growing interest in microscale analysis. Miniaturisation of analytical instruments has become a long-standing trend. Miniaturisation offers several advantages, including rapid separation times, high performance and throughput, reduced costs, etc. But the increased surface area to volume ratio can sometimes be a disadvantag
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Skivepitelcancer i huvud- och halsregionen (SCCHN) Kliniska aspekter Prognosen vid SCCHN är i stort sett oförändrat dålig sedan 30 år tillbaka; cirka hälften av patienterna dör av sin sjukdom. Trots stora tekniska framsteg kring behandlingsteknikerna (ofta en kombination av kirurgi, strål- och i viss mån cellgiftsbehandling) medför dAt present, clinical outcome or response to therapy can not be fully predicted in individual cases of squamous cell carcinoma of the head and neck (SCCHN). The overall aim of the present studies was to investigate potential prognostic factors, more closely related to the malignant progression of a tumor than the established markers, such as the TNM-classification system. Tumor samples were investi
